Athletics vs. Giants Prediction, MLB Picks for Thursday, June 25

Athletics vs. Giants is set for first pitch at 3:45 p.m. ET on Thursday, June 25, with the Giants favored and returning a 1.69x payout if they win, via PrizePicks.

The Giants hit a pair of home runs in the bottom of the ninth inning Wednesday to pull out a dramatic 2-1 victory. They'll now try to sweep this three-game series against the Athletics with SP Landen Roupp (5-7, 4.15 ERA) on the mound. The A’s will counter with SP Jeffrey Springs (3-7, 5.55 ERA), who's given up 28 runs (23 earned) over his last five starts.

Below, we’ll break down our Athletics vs. Giants prediction and picks for Thursday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Athletics vs. Giants Prediction, Winner Payout, Over/Under – Thursday, June 25

This has been a low-scoring series. The Giants combined for 5 runs in the first two games, while the Athletics only scored 2. The A’s have trouble scoring on the road, producing the fourth-worst OPS (.667) in baseball compared to a .742 mark at home.

With the Giants pulling off the comeback win yesterday, it marked the Athletics’ 17th blown save. Per FanGraphs, that's the second-most in baseball.

Their bullpen has struggled in general, recording a 4.98 ERA and a 1.43 WHIP. The Giants don’t exactly have a dominant pen, either, but they've only blown 9 saves.

Athletics vs. Giants Winner Payout, Over/Under – Thursday, June 25

The Giants enter Thursday’s game as a home favorite against the Athletics, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Athletics vs. Giants game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

• Spread: San Francisco Giants -1.5 (2.43x payout)
• Over/Under: 8.5 runs (1.78x payout Over)
• Game Winner Payout: Athletics 2.08x | Giants 1.69x

Make your Athletics vs. Giants prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live as of writing and is subject to change.

Athletics vs. Giants Prediction on Winner – 6/25/26

Here are the key game stats and trends behind our Athletics vs. Giants prediction on the winner for Thursday, June 25.

• The Athletics have lost four games in a row, scoring 1 or no runs in three of them.
• Loupp has a 3.58 xFIP and a 1.34 WHIP on the road, but he's even better at home with a 3.39 xFIP and a 1.29 WHIP.
• The A’s are heavily reliant on the home run, ranking sixth in baseball in the department. However, they're 13th in total runs scored. That could be a problem against Loupp because he has only allowed 0.7 HR/9 for his career.
• Springs gave up 2 runs (1 earned) over 6 innings against the Giants in May. However, the Giants finished the game with 10 runs after scoring 8 off two relievers in the eighth inning.
• The Athletics could be without two key members of their lineup with 3B Zack Gelof (hand) and SS Jacob Wilson (shoulder) battling injuries. That’s in addition to OF Brent Rooker (knee) already being on the injured list.

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Athletics vs. Giants Picks, Player Stats for PrizePicks: 6/25/26

Here are top Athletics vs. Giants picks to target on Thursday, June 25. Today's MLB picks for PrizePicks include SP Jeffrey Springs and OF/IF Casey Schmidt.

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Athletics SP Jeffrey Springs vs. Giants: 4.5 Strikeouts

• Springs has finished with 4 or fewer strikeouts in eight of his last 11 starts.
• After recording a 19.4% strikeout rate last season, the southpaw has a 20.1% mark this year.
• The Giants are a good contact- hitting team, registering the sixth-lowest K-rate (20.7%) in the majors.
• The last time he faced San Francisco, Springs posted only 3 strikeouts despite logging 6 innings.

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Giants OF Casey Schmitt vs. Athletics: 4.5 Hitter Fantasy Score

• Schmitt is locked in at the plate, hitting 15-for-31 (.484) with 1 home run and 3 doubles over his last eight games.
• The 27-year-old is having the best season of his career, recording a .228 ISO and a .362 wOBA.
• A main reason for Schmitt’s improved production is his 12.7% barrel rate. He didn’t finish with a barrel rate higher than 9.0% in any of the last three seasons.
• The emerging outfielder has a .393 wOBA and a 154 wRC+ vs. left-handed pitchers this year.

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The Giants will go for the sweep of the A’s at home on Thursday. The struggling Springs might not register many strikeouts, while Schmitt is in a favorable position to continue his recent hot streak.

Don’t wait until the first pitch — make your Athletics vs. Giants picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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