Angels vs. Guardians is set for first pitch at 1:10 p.m. ET on Wednesday, May 13, with the Guardians returning a 1.61x payout if they win, via PrizePicks.
The Guardians start promising young southpaw SP Parker Messick (4-1, 2.30 ERA), while the Angels deploy their own lefty in SP Reid Detmers (1-3, 4.33 ERA). After pitching exclusively in relief last season, Detmers has started all eight of his appearances this year.
Below, we’ll break down our Angels vs. Guardians prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
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Angels vs. Guardians Prediction, Winner Payout, Over/Under – Wednesday, May 13
The Guardians have plenty of holes in their lineup, which has contributed to them having the ninth-worst OPS in baseball (.687). The reason they've been successful is their pitching staff, which ranks third in strikeout rate (24.8%), 12th in xERA (3.96), and 13th in WHIP (1.28).
Cleveland recording plenty of strikeouts is noteworthy for their matchup with the Angels. Los Angeles has difficulties making contact, posting the second-highest strikeout rate (25.5%) in the majors.
Angels vs. Guardians Winner Payout, Over/Under – Wednesday, May 13
The Guardians enter Wednesday’s game as a home favorite against the Angels, returning a 1.61x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Angels vs. Guardians game on PrizePicks.
- Spread: Cleveland Guardians -1.5 (2.32x payout)
- Over/Under: 6.5 runs (1.66x payout on Over)
- Game Winner Payout: Angels 2.22x | Guardians 1.61x
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Team Picks data is live as of writing and is subject to change.
Angels vs. Guardians Prediction on Winner – 5/13/26
Here are the key game stats and trends behind our Angels vs. Guardians prediction on the winner for Wednesday, May 13.
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- The Guardians have held the Angels to 4 total runs over the first two games of this series. Los Angeles struck out 22 times during those losses.
- The Angels are 8-17 on the road this season.
- The Guardians have a losing record on the road (11-12) but are a respectable 12-9 at home.
- Cleveland is one of only four teams in the American League that has a positive run differential (+2). The Angels have the third-worst mark in the league at -30.
- The Guardians are 6-2 in games started by Messick. He's given up 2 or fewer runs in six of his outings.
Angels vs. Guardians Picks, Player Stats for PrizePicks: 5/13/26
Here are top Angels vs. Guardians picks to target on Wednesday, May 13. Today's MLB picks for PrizePicks include Guardians 3B Jose Ramirez and Angels OF Mike Trout.
Guardians 3B Jose Ramirez vs. Angels Projection: 1.5 Hits + Runs + RBI
- Ramirez is off to a slow start with his .210 batting average. He may have hit some rotten luck, however, as his .139 BABIP (per FanGraphs) is much lower than his career mark of .278.
- The star 3B is still hitting the ball hard, posting an 8.2% barrel rate and a 40.3% hard-hit rate. Both are higher than his career averages.
- Ramirez continues to have a good eye at the plate, recording more walks (31) than strikeouts (28) through 44 games.
- The 33-year-old tends to dominate left-handed pitching. Since the start of 2024, he has a .407 wOBA and a .272 ISO against them.
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Angels OF Mike Trout vs. Guardians Projection: 5.5 Hitter Fantasy Score
- Trout is 3-for-8 with 1 double and 2 walks in this series.
- It's been a resurgent season for the superb outfielder, who has a .409 wOBA and a .262 ISO.
- After finishing with a career-worst 32.0% strikeout rate last year, Trout has a 25.7% K-rate this season.
- In his 16th campaign in the majors, Trout has a 23.0% barrel rate and a 51.0% hard-hit rate. The barrel rate would be the best mark of his career and the hard-hit rate is tied for his fourth-best performance in the category.
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The Guardians aim to pull off the sweep of the Angels at home on Wednesday. Ramirez could play a key role in a potential victory with a left-handed pitcher on the mound for Los Angeles. As well as Messick has pitched, he may still have his hands full with Trout, who is having a bounce-back season.
Don’t wait until the first pitch — make your Angels vs. Guardians picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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