A monster 10+ game MLB slate slate gives us plenty of opportunities for MLB DFS on Wednesday. We’ve got today’s top MLB player, including pitchers and hitters to target on PrizePicks for today’s slate, plus a home run pick.
Whether you’re backing a hitter to go yard or just get on base, Wednesday’s MLB slate is stacked with opportunities on PrizePicks. Below, we’ve got six picks to help you build your winning Lineups for Wednesday MLB.
Don’t forget to head to the PrizePicks MLB board, lock in your picks, and submit your Lineup to get in on the real money MLB action before the first pitch.
Best MLB Hitter Picks, Predictions: 4/23/25
Here are the top MLB DFS picks and predictions for PrizePicks today. Use this analysis to build your Lineups on PrizePicks MLB on Wednesday, April 23. Click to read more about each pick.
- Blue Jays SS Bo Bichette – 7 Hitter Fantasy Score
- Pirates CF Oneil Cruz – 1.5 Hits+Runs+RBIs (Goblin)
- Home Run Pick: Red Sox 3B Alex Bregman
Blue Jays SS Bo Bichette – 7 Fantasy Score
- Astros P Ryan Gusto in only 65+ plate appearances this season has allowed a 10% barrel rate, 61% hard-hit percentage and 41% fly ball rate.
- Gusto throws a fastball over 55% of the time this season.
- Against the right fastball this season in 20+ plate appearances, Bo Bichette owns a 15% barrel rate, 85% hard hit percentage, and a 31% fly ball rate.
- Dating back to last season and over 70+ appearances, Bichette owns a 78% hard hit percentage against the right-handed fastball.
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Pirates CF Oneil Cruz – 1.5 Hits+Runs+RBIs (Goblin)
- In 50 plate appearances this season against right-handed pitchers, Oneil Cruz produced a 35% fly-ball rate and a whopping 71% hard-hit rate.
- Across 120 plate appearances against right-handed fastballs, Cruz has maintained a 20% barrel rate and a 68% hard-hit rate.
- Over his last 110 plate appearances, Jack Kochanowicz allowed a 30% fly-ball rate and a 10% barrel rate.
Note: Goblin picks decrease your payout on PrizePicks, as they are easier projections to hit.
Home Run Pick: Red Sox 3B Alex Bregman
- In his last 150 plate appearances against right-handed hitters, Mariners pitcher Emerson Hancock has allowed a 14.5% barrel rate and 55% hard-hit rate.
- He has also given up a 35% fly-ball rate over that same stretch — showing he’s giving up hits in the air.
- Over 80+ plate appearances versus right-handed pitching, Bregman recorded a 39% fly-ball rate, and a 53% hard-hit rate paired with a 10% barrel rate
Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.
Make MLB DFS Picks on PrizePicks
With a loaded Wednesday MLB slate, now is the time to get in on the action on PrizePicks. With every hitter on the board, you can build your Lineup however you’d like.
All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — and get them right to win.
Whether you’re going with demons or goblins, there’s always real money sports action waiting for you on PrizePicks. Stay locked in on the Playbook all season long for MLB player picks every day.
