We’re only one week into the college football season, and the rankings shake-up has already started. Ohio State grabbed the No. 1 spot after knocking off Texas; now Week 2 brings us some key games, including one top 25 ranked game — No. 15 Michigan vs. No. 18 Oklahoma — plus plenty of rivalry games.
The Michigan-Oklahoma showdown features plenty of players to highlight for Week 2 CFB DFS on PrizePicks, including Oklahoma QB John Mateer. The Week 2 rivalry games get kicked off in Ames with Iowa vs. No. 16 Iowa State at 12 p.m. ET — a matchup which tends to be low scoring.
We'll break down the top CFB picks for Saturday on PrizePicks CFB DFS in Week 2.
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Oklahoma QB John Mateer Projection: 241.5 Passing Yards
Michigan vs. Oklahoma Pick – 7:30 p.m. ET
- Oklahoma QB John Mateer exploded for 392 passing yards (a record for an Oklahoma debut) with 3 pass TDs and 1 rush TD in the 35-3 win over Illinois State.
- As the full-time starter last season for Washington State, Mateer had at least 2 overall touchdowns in 11 of 12 games.
- Mateer led all FBS quarterbacks with 44 passing and rushing TDs in 2024 at Washington State.
- Michigan allowed at least 2+ TDs in 9-of-13 games last season, including multiple touchdown passes in five.
- Michigan gave up 2 pass TDs last week to New Mexico. According to ESPN, they were ranked 130th out of 136 teams coming into the season.
Iowa State QB Rocco Becht Projection: 230.5 Passing Yards
Iowa vs. Iowa State Pick – 12 p.m. ET
- Iowa State QB Rocco Becht threw for 183 pass yards in the Week 0 matchup against Kansas State and 278 yards against FCS program South Dakota State in Week 1.
- Becht threw for less than 236 passing yards in three of his final four regular-season games in 2024.
- Becht threw for 272 yards in last year’s matchup against Iowa.
- A big chunk of those yards came from a 75-yard touchdown pass to WR Jaylin Noel, who is now in the NFL.
- Iowa was 44th in passing yards allowed last season (209.0).
- The Cyclones could be shifting more towards the run. Last year, they ran on 51.67% of their offensive plays; this season, it is 58.97%.
Virginia Tech QB Kyron Drones Projection: 221.5 Passing Yards
Vanderbilt vs. Virginia Tech Pick – 7:30 p.m. ET
- Virginia Tech QB Kyron Drones threw for 221 yards in the 24-11 loss to South Carolina.
- Drones passed for a career-high 322 yards last season against Vanderbilt.
- Vanderbilt was 111th in passing yards allowed (252.8) in 2024.
- Drones had 8 completions of 20 or more yards in last season’s game against Vanderbilt.
- Vanderbilt was 112th in 20+ passing yard plays allowed in 2024 (46).
Arizona State RB Kyson Brown Projection: 62.5 Rushing Yards
Arizona State vs. Mississippi State Pick – 7:30 p.m. ET
- Arizona State RB Kyson Brown ran for 73 yards on 7 carries in the Week 1 win against Northern Arizona.
- Brown had the second-most rushing yards among Arizona State RBs last year with 351. Last year’s rushing leader, RB Cam Skattebo, is now in the NFL.
- As a native of Tupelo, Miss., this is a homecoming for Brown. He will have about 50 friends and family for the game against Mississippi State.
- Even though Arizona State QB Sam Leavitt likes to run the ball (110 rushes for 443 yards in 2024), there should still be plenty of opportunities for Brown for RB1.
- In 2024, Arizona State was 19th in run play percentage (59.52%) and 40th in plays per game (70.9).
- Mississippi State was 130th in rushing yards allowed per game in 2024 (225.2).
Kentucky RB Seth McGowan Projection: 60.5 Rushing Yards
- Kentucky RB Seth McGowan ran for 78 yards in the 24-16 win against Toledo in Week 1.
- Although his 18 carries led the team, RB Dante Dowdell only had 4 fewer carries and QB Zach Calzada had 8 fewer.
- Dowdell was the better-performing running back in that game with 129 rushing yards.
- For the matchup against Toledo, the depth chart revealed Dowdell “or” McGowan as the starter, meaning these two could continue to split carries.
- Mississippi had the best run defense in the league last season, allowing 85.1 rushing yards per game.
Oregon RB Noah Whittington Projection: 19.5 Longest Rush
Oklahoma State vs. Oregon Pick – 3:30 p.m. ET
- Oregon RB Noah Whittington led the team with 68 rushing yards in the win against FCS program Montana State.
- Whittington ran a max speed of 20.8 miles per hour, resulting in a team-high 35-yard run.
- Whittington had a 20-yard run in three of his final four regular-season games last year.
- Oklahoma State finished 128th in rushing yards allowed per game (223.4)
- Oklahoma State allowed 17 runs of 20 yards or more last year (129th).
- Oklahoma State's defense gave up at least 38 points in eight straight games to finish Big 12 play last year.
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Arizona St. WR Jordyn Tyson Projection: 98.5 Receiving Yards
Arizona State vs. Mississippi State Pick – 7:30 p.m. ET
- Arizona State WR Jordyn Tyson led the team with 141 receiving yards in the Week 1 win over Northern Arizona, 38-19.
- Tyson has the potential to be the best wide receiver in the Big 12; last year, he finished fifth in the conference in receiving yards (1,183). The four receivers who finished higher are now in the NFL.
- Tyson has four straight games with at least 120 receiving yards.
- Tyson played the fifth-most snaps amongst FBS wide receivers in 2024 (958).
- Last season, Mississippi State finished 127th in passing yards allowed per game (471.0), which was last in the SEC.
- Mississippi State allowed three different receivers to catch for 100 yards or more in 2024.
Baylor WR Kole Wilson Projection: 23.5 Longest Reception
Baylor vs. #17 SMU Pick – 12 p.m. ET
- Baylor WR Kole Wilson had a game-leading 8 catches for 134 yards in the 38-24 loss to Auburn in Week 1.
- Wilson had a 57-yard reception in that matchup, the fourth time he had at least one 50-yard catch in a game.
- Wilson has at least one 30-yard reception in seven of his last nine games.
- Baylor likes to have Wilson run deep routes, according to PFF, 38 of his 67 routes run (47.7%) last year were 10 yards or deeper.
- SMU allowed 19 catches for over 30 yards in 2024 (88th).
Make Week 2 CFB DFS Picks on PrizePicks
The best part about Saturdays in the fall is entire days filled with college football. Whether you're watching Michigan vs. Oklahoma or Iowa vs. Iowa State, PrizePicks is the best way to cash in on your college football takes.
Just pick your players — including John Mateer and Rocco Becht, predict More or Less on their stat projections, and get paid when your picks are right in PrizePicks CFB DFS game.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
