The Portland Trail Blazers vs. San Antonio Spurs NBA Playoff game is set to tip off at 8:00 p.m. ET on Tuesday, April 21, with the Spurs entering as 10.5-point favorites on the spread on PrizePicks.
In Game 1, the Spurs took the lead halfway through the first quarter and never relinquished it, winning (and covering) 111-98. Can the Trail Blazers do anything to hang with them in Game 2?
Below, we'll break down our Trail Blazers vs. Spurs prediction and picks for Tuesday’s NBA Playoff game, including the spread, over/under, and key player picks for PrizePicks.
Make your picks for Trail Blazers vs. Spurs on PrizePicks now.
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Trail Blazers vs. Spurs Prediction, Spread, Over/Under – Tuesday, April 21
The Trail Blazers played the Spurs tough in Game 1. They stuck around for quite a while, eventually cutting the lead to just two points in the third quarter, but simply ran out of firepower against a team that's been playing exceptional basketball for the better part of three months.
Perhaps a little more juice from PG Jrue Holiday is what the Blazers need to pull off an upset in Game 2? Holiday just went just 4-of-15 from the field, including 1-7 from 3-point land, finishing with 9 points and 11 assists.
As one of the few players on this Blazers team with legitimate postseason experience, it’s important that Holiday puts forth more efficient shooting numbers.
The Spurs, meanwhile, did what they've done for what feels like the entire season. Since February 1, San Antonio has won 31 of its last 35 games. Removing games played vs. the Denver Nuggets, that becomes 31 of 32.
San Antonio is led by freak of nature C Victor Wembanyama. The unanimous Defensive Player of the Year winner is a presence on every single possession and on offense, he has guard-like handles and step-back treys in his bag.
Trail Blazers vs. Spurs Spread, Over/Under – Tuesday, April 21
The Spurs enter Tuesday’s game as 10.5-point home favorites against the Trail Blazers, returning a 1.12x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Trail Blazers vs. Spurs game on PrizePicks.
- Spread: San Antonio Spurs -10.5 (1.75x payout)
- Over/Under: 216.5 (1.88x payout on Over)
- Game Winner Payout: Trail Blazers - 5.26x | Spurs - 1.12x
Play the Trail Blazers vs. Spurs spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Portland Trail Blazers vs. San Antonio Spurs Timeline
Here is the full Trail Blazers vs. Spurs timeline, including the playoff series game-by-game and recent matchup history.
All-Time: Spurs, 115-100
Regular Season: Spurs, 2-1
Series: Spurs, 1-0
Trail Blazers vs. Spurs First Round Timeline, Schedule for 2026 NBA Playoffs
- Game 1: Spurs 111, Trail Blazers 98
- Game 2: Tuesday, April 21, 8:00 p.m. ET in San Antonio
- Game 3: Friday, April 24, 10:30 p.m. ET in Portland
- Game 4: Sunday, April 26, 3:30 p.m. ET in Portland
- Games 5-7 are if necessary
Trail Blazers vs. Spurs Prediction on Spread For NBA Playoffs First Round
Here are the key game stats and trends behind our Trail Blazers vs. Spurs prediction on the Spread for Tuesday, April 21.
Lock in your Trail Blazers vs. Spurs prediction on PrizePicks before the line moves.
- The Spurs have gone 47-35-2 (57.3%) against the spread (ATS) this year, the fourth-best record in the NBA.
- Meanwhile, the Blazers have struggled to cover on the road, going just 20-23 (46.5%) ATS.
- San Antonio owned the second-best net rating in the NBA (+8.4) during the regular season, a full 8.8 points ahead of the Trail Blazers (-0.4).
- The Blazers' offense is centered around them cooking from 3-point land. They ranked third in the NBA in percentage of field goal attempts taken from deep (46.9%). Unfortunately for Portland, San Antonio holds foes to 35.2% from deep, eighth-lowest in the league.
- Due to the comfort of having Wemby patrolling the paint, the other Spurs defenders have the luxury of being a bit more aggressive in closing out perimeter shots. We saw this in Game 1, when the Blazers shot 10-of-38 (26%) from distance.
Trail Blazers vs. Spurs Player Picks, Stats for PrizePicks – 04/21/26
Here are the top Trail Blazers vs. Spurs picks to target on PrizePicks for Tuesday, April 21. Today’s NBA picks for PrizePicks include SF Deni Avdija and C Victor Wembanyama.
Trail Blazers SF Deni Avdija vs. Spurs Projection: 39.5 Pts + Rebs + Asts
- Playoff Avdija has been cooking, going for 41-7-12 in the Play-In Tournament before dropping 30-10-5 in the first game of this series.
- Avdija has exceeded this projection in every game he has played against San Antonio this year. His stat lines in the regular season were 29-6-6 (41 PRA), 29-10-10 (49 PRA), and 37-6-8 (51 PRA).
- Both of these teams rank in the top 12 in pace, suggesting that there could be a healthy amount of possessions and opportunities to accrue stats.
- Deni averaged 37.8 PRA this season but played just 33.3 minutes per game. He's played 39 minutes in both postseason games so far.
Add Deni Avdija to your PrizePicks Lineup now.
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Spurs C Victor Wembanyama vs. Trail Blazers Projection: 43.5 Pts + Rebs + Asts
- In April, Wemby averaged 33-13.5-4 (50.5 PRA) per game.
- He played just 29.2 minutes per game this season, but in his playoff debut, he logged 33 minutes right away.
- Even with the Spurs being 12th in pace, the Blazers are ninth, making this a tempo-up environment for Wembanyama and company.
- Wembanyama has taken his game to another level at home. In San Antonio, he's posting 2.8 more points, 0.5 more rebounds, and 0.3 more assists per game than on the road while shooting 3.5% better from the field and 7.1% better from 3-point land.
Add Victor Wembanyama to your PrizePicks Lineup now.
NBA Playoffs Live Picks: Trail Blazers vs. Spurs on PrizePicks for Game 2
Here are some in-game angles to target for your Trail Blazers vs. Spurs live picks in tonight’s game.
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- If the 3-balls are falling for Wembanyama, then the Spurs are even more dangerous. Wemby is shooting 37.9% from deep in wins compared to just 24.7% in losses.
- The Spurs have the second-best first-quarter net rating in the league (+14.7). Portland struggles in the opening frame at -4.0, ninth-worst in the NBA.
- Keep an eye on the second quarter. The Spurs rank second in the NBA in defensive rating in the frame (107.6), while the Blazers are ninth (110.9).
- The second quarter is both teams' best quarter in terms of defensive rating.
Make Trail Blazers vs. Spurs Picks on PrizePicks
The NBA Playoffs are finally here, and we’ve got fun first-round series all over the place. Can the Blazers rebound in Game 2 to tie the series up, or will the Spurs continue to roll by taking a 2-0 lead to Portland?
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