At the end of the 2025 college football season, we might look back at Week 7 as a turning point for many teams — this is where it gets real. Below, we'll give you the top CFB DFS picks for Saturday's games in Week 7, including PrizePicks picks today in the marquee college football matchups.
The matchup of the day is No. 7 Indiana vs. No. 3 Oregon at 3:30 p.m. ET on CBS. This is not only for a possible chance to play in the Big Ten Championship. but also an opportunity for QBs Dante Moore and Fernando Mendoza to become strong Heisman Trophy contenders.
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We have projections to target for both players in this top-ten matchup, plus many more across QB, RB, and WRs to target this week.
There is another must-watch game when No. 8 Alabama travels to Columbia to try and give No. 14 Missouri its first loss of the year.
PrizePicks is the simplest way to win real money with your CFB picks this Saturday and every week; just select your players, predict More or Less on their stats, and cash in when your picks are correct.
Let's dive into the top college football DFS picks for Saturday, October 11, on PrizePicks.
Saturday CFB DFS Picks for Week 7: October 11
Here are the top CFB DFS picks for Saturday, October 11, in Week 7 of college football, including PrizePicks picks for Alabama vs. Missouri and Indiana vs. Oregon.
Use this analysis to build your PrizePicks CFB Lineups for Saturday's Week 7 games.
Oregon QB Dante Moore Projection: 263.5 Pass+Rush Yards
No. 7 Indiana vs. No. 3 Oregon Pick – 3:30 p.m. ET
- Dante Moore has more than 263 pass+rush yards in three of his last four games.
- Moore has the third-highest completion rate for any quarterback with a minimum of 70 attempts.
- The sophomore worked on building speed in the offseason and hit his goal of running 21 MPH.
- The UCLA transfer has 70 straight pass attempts without an interception.
- The Hoosiers' defense has only 1 INT in two games against Power Four opponents.
- Indiana is 44th in completion percentage allowed (60.3%).
- Oregon’s offensive line is seventh in pressure rate allowed (21.9%).
- Indiana’s defense is pressuring quarterbacks on 35.2% of snaps, which ranks 48th.
Indiana QB Fernando Mendoza Projection: 226.5 Passing Yards
No. 7 Indiana vs. No. 3 Oregon Pick – 3:30 p.m. ET
- Mendoza has more than 226 passing yards in four straight games.
- Oregon is sixth in defensive pass EPA (0.257).
- The Cal transfer has faced one previous opponent who is ranked inside the top ten in defensive pass EPA. That was Illinois, where he threw for 265 yards and 5 TDs.
- The Ducks' defense is 32nd in pressure rate (38.0%).
- According to PFF, the junior from Miami has the sixth-highest yards per attempt when under pressure.
- Mendoza has the tenth-best completion rate (73.0%).
- Oregon allows the lowest completion rate (44.32%). However, they have not faced a quarterback who is currently ranked in the top 60 in completion rate.
Texas QB Arch Manning Projection: 206.5 Passing Yards
No. 6 Oklahoma vs. Texas Pick – 3:30 p.m. ET
- Manning has faced one opponent who ranks inside the top 50 in defensive pass EPA: seventh-ranked Ohio State, where he threw for 170 yards.
- Oklahoma is third in defensive pass EPA (-0.293).
- Peyton Manning’s nephew is 115th in pass success rate (37.5%).
- The Sooners are allowing the lowest success rate against the pass (23.6%).
- OU has only given up more than 200 passing yards in one of five games.
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Missouri RB Ahmad Hardy Projection: 96.5 Rushing Yards
No. 8 Alabama vs. No. 14 Missouri Pick – 12 p.m. ET
- Mizzou RB Ahmad Hardy is the nation’s leading rusher at 730 yards.
- Hardy has rushed for more than 100 yards in all five games this year.
- Missouri has not faced a defense that is currently inside the top 50 in EPA per rush.
- Alabama is 15th in defensive EPA per rush (-0.081).
- According to PFF, Missouri’s strength of schedule ranks 104th.
Ohio State WR Carnell Tate Projection: 68.5 Receiving Yards
No. 1 Ohio State vs. No. 17 Illinois Pick – 12 p.m. ET
- Carnell Tate has more than 100 receiving yards in two of his last three games.
- The junior’s 86.4% catch rate is seventh (minimum 21 targets).
- Illinois is 106th in completion percentage allowed (66.4%).
- The Fighting Illini are 116th in yards after contact to pass catchers (4.24).
- Illinois is 118th in points allowed per quality drive (4.0).
Clemson WR Bryant Wesco Projection: 62.5 Receiving Yards
Clemson vs. Boston College Pick – 7:30 p.m. ET
- WR Bryant Wesco has more than 62 receiving yards in four of five games this season.
- The sophomore leads the team in catches (26) and receiving yards (431)
- Boston College is 96th in passing yards allowed per game (250.5).
- Boston College has allowed an FBS opponent to have a pass catcher finish with 70+ receiving yards in three straight games.
- The Eagles are 127th in defensive pass EPA (0.182).
- BC is 68th in yards after contact to pass catchers (4.6).
- Wesco is eighth by averaging 7.5 yards after the catch (minimum 34 targets).
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USC RB Waymond Jordan Projection: 72.5 Rushing Yards
No. 15 Michigan vs. USC Pick – 7:30 p.m. ET
- Waymond Jordan has more than 72 rushing yards in four straight games.
- Michigan is sixth in defensive rush EPA (-0.120).
- USC has not faced an FBS opponent ranked in the top 45 for defensive rush EPA.
- The junior has the fourth-most yards after contact (472).
- Michigan is 24th in average yards after contact vs. running backs (2.38).
Make Week 7 CFB DFS Picks on PrizePicks
With two games between top 25 teams on Saturday, Week 7 of college football could produce exciting games as we enter the key part conference play with huge implications for the standings and playoff rankings.
Whether you're watching SEC matchups of Alabama vs. Missouri or the Big Ten clash between Indiana and Oregon, PrizePicks is the best way to cash in on your college football picks.
Just pick your players — including Dante Moore and Fernando Mendoza — predict More or Less on their stat projections, and get paid when your picks are correct on PrizePicks CFB.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
