Seventh-ranked Indiana travels to Eugene to face the third-ranked Oregon Ducks in a top-10 battle with national title and Big Ten title implications. This is the first conference meeting between two teams who have sparred just three previous times. The undefeated schools meet Saturday at 3:30 ET on CBS.
The rumble will feature two of the best QBs in the nation in Indiana’s Fernando Mendoza and Oregon’s Dante Moore, who are among the top five contenders on many Heisman lists. Mendoza is second in the nation in passer rating, while Moore enters sixth. These two QBs have met before in a Pac-12 battle between Cal and UCLA.
With only four teams with a perfect 2-0 record in the Big Ten, the winner will have a leg up in the race for the two Big Ten championship game spots.
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Indiana vs. Oregon Prediction, CFB Picks
Indiana and Oregon meet for the first as conference opponents and only the second time in the last 60 seasons. Oregon has won two of those three, with Indiana taking the last one in 2004 in Eugene.
Both teams are 5-0 to start the season for the second consecutive year. Combined, the two teams have lost one regular season game over the last two seasons. Both teams advanced to the College Football Playoff last season, falling in their first game.
After tough wins in Week 5 (Oregon over Penn State and Indiana over Iowa), both teams were on a bye in Week 6.
Indiana Hoosiers Preview
The Indiana Hoosiers, who advanced to the College Football Playoff last season, are 5-0 for the second consecutive season, with wins over ninth-ranked Illinois and Iowa in their last two games. Prior to 2024, the Hoosiers had not started a season 5-0 since 1967.
Indiana enters Week 7 with the fifth-best offense in the country, gaining 538.2 yards per game. The Hoosiers are averaging 47.2 points per game through their first five games, fourth-best in the nation. The damage has been done on the ground, where Indiana is averaging 267.8 rush yards a game, fifth-best in the country.
It’s not just offense for the Hoosiers, who also rank third in scoring defense (9.6 PPG) and fifth in total defense (221.4 yards per game allowed). Indiana is the only team in the country in the top five in scoring offense and defense.
Oregon Ducks Preview
The Oregon Ducks, who won the Big Ten title and earned first round bye in last year’s CFP, are 5-0 for the second straight year and for the third time in the last four seasons. Oregon has won 18 consecutive non-bowl games, last losing a non-bowl game in the 2023 Pac-12 title game to Washington. The Ducks have yet to lose a Big Ten game since joining the conference prior to the 2024 season. Oregon went 9-0 and then won the Big Ten title game last season and are 2-0 this season in conference play.
The Ducks enter Week 7 with the sixth-best scoring offense in the country, scoring 46.6 points per game and ninth in total yards at 503.8 yards per game. The defense is seventh in yards allowed (238.2) and sixth in scoring defense at 12.2 points per game. Four out the five games have been won by 20+ points with the win over Penn State goning to OT.
Indiana vs. Oregon Picks – Saturday 10/11
Here are the player picks to target in PrizePicks real money college football game and in CFB DFS, including Fernando Mendoza and Dante Moore.
Indiana QB Fernando Mendoza Projection: 229.5 Passing Yards
- Mendoza, one of the Heisman favorites, has thrown for 230+ yards in each of his last four games. He is considered one of the top picks in April’s NFL draft and a top Heisman candidate
- He has 16 passing TDs in five games, tied for second best in the country.
- Mendoza has completed 73% of his passes, tenth-best in the nation.
- The Indiana star also has 2 rushing TDs on the season for a total of 18 total scores.
Oregon QB Dante Moore Projection: 250.5 Passing Yards
- Oregon QB Dante Moore, also a Heisman contender, has 14 passing TDs, tied for fourth in the nation.
- Moore enters with a 74.6 completion percentage, fourth-best in the country.
- The Ducks' signal caller has thrown for 240+ yards in three of five games this season.
- He has also added 122 rushing yards, 88 of which have come in his last two games.
- Moore is considered a top Heisman candidate entering this game.
Indiana RB Kaelon Black Projection: 32.5 rushing yards
- Kaelon Black is one half of a two-headed RB monster, the other being Roman Hemby. Both have 300+ rushing yards through five games.
- Black has 35+ rushing yards in all five games this season and in his last six games overall.
- Black’s 6.3 yards per rush leads all Indiana RBs, minimum 10 carries.
Make CFB Picks on PrizePicks
Indiana vs. Oregon pits two top 10 teams in a Big Ten matchup with national and conference title implications. Fernando Mendoza and Dante Moore, two of the top QBs in the country, square off in a game that could have an impact on the Heisman race.
No matter what your take on this Saturday afternoon matchup is, you can win real money with your Indiana vs. Oregon predictions on PrizePicks while you watch.
Simply pick your players — from Mendoza to Moore — predict More or Less on their projected stats, and win cash when you're right. It's that easy.
Check out the Playbook throughout the 2025 college season for more college football picks and predictions from our team of experts
