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Thunder vs Celtics Prediction, Spread, NBA Picks for Wednesday, March 25

Celtics G Payton Pritchard dribbles to the basket vs. Bulls.
AP Photo/Charles Krupa

Today’s 12-game NBA lineup is headlined by a heavyweight clash between the Oklahoma City Thunder (57-15) and the Boston Celtics (47-24).

The Thunder have won 12 consecutive games and carry the best record in the NBA, while the Celtics are 4-1 in their last five games and sit second in the Eastern Conference standings. Who could have the upper hand for tonight’s 7:30 p.m. ET tip-off?

Let’s break down the matchup, make a Thunder vs. Celtics prediction, and circle a pair of player projections to target for NBA picks for PrizePicks.

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Thunder vs. Celtics Prediction, Spread, Over/Under

During Oklahoma City’s 12-game winning streak, it’s only 3-9 against the spread (ATS) in the split. The under is also 9-3 over the Thunder’s last 12 games.

Boston features similar trends, holding a 4-6 ATS record while the under is 7-3 for its past 10 matchups. 

In the last 10 head-to-head matchups, OKC is 6-4 outright and 8-2 ATS. The two met on March 12, with the Celtics covering a nine-point spread in the 104-102 loss.


Thunder vs. Celtics Spread, Over/Under

The Thunder are 2.5-point favorites tonight and feature a 1.72x payout to win on PrizePicks Team Picks if they win outright.

The Celtics, meanwhile, are home underdogs with a 2.12x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.

  • Spread: Oklahoma City Thunder -2.5
  • Over/Under: 218.5
  • Gamer Winner Payout: Thunder 1.72x | Celtics 2.12x

Team picks data is live as of writing and is subject to change.


Thunder vs. Celtics Injury Report

Let’s have a look at the full Thunder vs. Celtics injury report for Wednesday’s matchup, via NBA.com.

Thunder Injury Report

Oklahoma City features a healthy rotation for tonight.

Celtics Injury Report

  • C Nikola Vucevic (finger): OUT

Thunder vs. Celtics Prediction on Over/Under – 3/25/26

In the previous head-to-head matchup, the two combined for only 206 points, going under the 216.5 total. According to NBA Advanced Stats, the Thunder lead the Association in defensive rating, while the Celtics rank fourth.

Boston also plays at the slowest pace in the NBA, leading to opponents shooting only 86.7 field goal attempts per game (sixth). While Oklahoma City has the 14th-quickest pace, it still limits teams to 88.3 field goal attempts per game (13th).

The Celtics logged only 87 shots while the Thunder posted 84 field goal attempts in the previous clash. Another slow-paced, low-scoring bout could be ahead.

Furthermore, both squads sport elite interior defense, with Boston giving up only 40.1 points in the paint per game (first) while Oklahoma City surrenders 41.2 per contest (second). That translated to the last meeting, as the Thunder (44) and Celtics (34) were each under 45 paint points.

According to Dunks & Threes, Boston (first) and OKC (second) allow the lowest rim shot distributions. With easy buckets potentially out of the equation, could points be a rarity tonight?


Thunder vs. Celtics Picks for PrizePicks Today: 3/25/26

Check out a pair of Thunder vs. Celtics NBA picks to target for Wednesday, March 25, on PrizePicks. Thunder G Jared McCain and Celtics G Payton Pritchard headline player stat projections via PrizePicks.

Thunder G Jared McCain vs. Celtics Projection: 6.5 Points

  • While both teams have stingy interior defenses, the perimeter is leaky, as the Celtics rank 28th in 3-point shot distribution allowed, per Dunks & Threes.
  • Oklahoma City finally has a healthy rotation, as Thunder G Jalen Williams returned on March 23.
  • McCain still posted 25 minutes and 13 points, while Williams was limited to 20 minutes on Monday.
  • Over the last three games, McCain averaged 27.3 minutes and 19.0 PPG, while converting 12-of-26 3-point shots (46.2%).

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Celtics G Payton Pritchard vs. Thunder Projection: 14 Points

  • Oklahoma City ranks 25th in 3-point shot distribution allowed, surrendering 14.3 made triples per game (28th).
  • Pritchard is among Boston’s 3-point specialists, totaling 7.1 attempted treys per contest (third on the team).
  • He shoots 35.9% on the season and has elevated that to 40.6% over his last four games.
  • With the 6’1” guard posting 3.3 made 3-pointers and 16.8 PPG over his last four games, Pritchard could stay hot from beyond the arc on Wednesday.

Make Thunder vs. Celtics Picks on PrizePicks

A potential slow pace paired with strong rim protection could mean another low-scoring bout between the Thunder and Celtics. However, suspect 3-point defenses open the door for reserve guards to excel, including McCain and Pritchard.

You can make your Thunder vs. Celtics picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states

Stick around with the Playbook for continued NBA predictions, picks, and news.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Riley Thomas is a 2021 graduate of Ohio University who has worked for FanDuel Sportsbook and BetUS Sportsbook. He specializes in covering the NFL, NBA, college football, and college basketball. In Riley's free time, you can find him cheering on Ohio State and Kentucky or playing video games and reading the latest comics.

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