Wednesday, November 4, features 28 of 30 NBA teams in action with a loaded 14-game schedule. A doubleheader between the 76ers vs. Pistons and Mavericks vs. Spurs on ESPN headlines the day, but there are several more intriguing games on the slate.
For example, the Rockets, Grizzlies, and Trail Blazers are all off to hot starts with only one loss. Portland is favored by only 2.5 points on the spread vs. the Suns tonight, per PrizePicks, and out east, the Hawks (-2.5) vs. the Wizards also feature a low point spread.
Below, we’ll dive into Wednesday’s schedule and highlight our best NBA predictions today, including spreads, over/unders, player picks, and more, all found on PrizePicks.
Make your NBA prediction on PrizePicks now!
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Best NBA Predictions, Picks for PrizePicks Today – Wednesday, November 4
Before we highlight our top NBA predictions and picks today, here’s a full look at tonight’s schedule, featuring when each game tips and point spreads via PrizePicks.
Following Monday’s battle, the Cavaliers (4-3) and Thunder (5-2) collide for another head-to-head matchup. Oklahoma City leaned on a 43-point performance from G Shai Gilgeous-Alexander in the 117-112 win as it continues to battle injuries. Another close one could be ahead, with PrizePicks tabbing the Thunder as a 3.5-point favorite on the spread.
Out west, the Nuggets (3-3) play host the Raptors (4-3), and both teams have struggled to find consistency in the early going. Denver’s offense has yet to find its groove, and Toronto has consistently found itself in high-scoring contests thus far. According to PrizePicks, the over/under is 231.5 in this matchup.
Let’s break down the Cavaliers vs. Thunder and Raptors vs. Nuggets for our NBA predictions today, including point spreads, over/unders, and player projections via PrizePicks.
Whatchu on? Make your NBA picks on PrizePicks.
Cavaliers vs. Thunder Prediction on Spread – 11/4/26
The NBA has already been hit hard by injuries, and no team has suffered more than the Thunder. Alongside a season-ending injury to F Jalen Williams (leg), G Cason Wallace (shoulder) is set to miss most of the regular season, while C Chet Holmgren (knee) is expected to miss eight to 10 weeks.
According to the NBA injury report, the frontcourt depth could be even more dire tonight, with Thunder F Jaylin Williams (back) questionable. For the Cavaliers, their wings are thin with G Peyton Watson (hamstring) and G Jaylon Tyson (ankle) out on Wednesday.
In Monday’s clash, Thunder G Shai Gilgeous-Alexander dominated the workload by taking 35 field goal attempts in a 43-point outburst. Cleveland will once again be without perhaps its two best shots of defending SGA, meaning G Donovan Mitchell, G James Harden, and rookie G Meleek Thomas will likely split duties on the defensive end.
The Cavs were also thoroughly dominated in the interior, losing the rebound battle by 8 and the paint points tussle by 20. However, we could see regression on the glass, as Cleveland has a 68.1% rebound rate (16th) compared to OKC’s 66.8% (20th), per NBA.com. That gap could only widen if Jaylin Williams is out tonight.
However, the paint battle remains a concern, with the Thunder giving up only 37.1 paint points per game (the fewest). But this may also regress without Chet Holmgren’s elite 98.4 defensive rating. In comparison, Thunder C Isaiah Hartenstein (112.9) and C Aday Mara (109.3) have defensive ratings sitting much higher.
According to databallr, the Cavaliers are tied for the 10th-highest 3-point shot distribution (45.6%). In line with their 41.0 3-point shot attempts per game (seventh), they got up plenty of shots from deep (49) in Monday’s game.
Cleveland shoots 36.9% from beyond the arc (ninth), and that continued with Monday’s 36.7% mark. The Thunder are allowing a healthy 46.9% 3-point shot distribution (third-highest), and that’s like playing with fire against this Cavs team.
Lock in your Cavaliers vs. Thunder prediction before tipoff on PrizePicks!
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Cavaliers G Meleek Thomas vs. Thunder: 12.5 Points
- Meleek Thomas was one of the surprise slides of the 2026 NBA Draft, falling to the 34th overall pick in the second round. He’s been on a consistent rise since, including 27.3 PPG and a 58.5% effective field goal percentage in the Summer League, per The 5th Factor.
- Thomas has carried that excellent play into the regular season and has quickly increased his minutes. He made his first career start on Monday, filling in for Peyton Watson and Jaylon Tyson. He answered the call with 17 points in 26 minutes.
- The rookie wasn’t shy about letting it fly, attempting 16 shots and 9 3-point attempts.
- After shooting only 33.3% from deep on Monday, positive regression could be ahead considering his 47.6% 3-point percentage over four outings.
- As mentioned, the Thunder give up plenty of 3-point attempts, with opponents launching 41.4 per game (25th), and Thomas has taken 47.0% of his shots from 3-point land.
Add Meleek Thomas to your PrizePicks lineup now!
Raptors vs. Nuggets Prediction on Winner – 11/4/26
Despite the Raptors carrying the Association’s seventh-best defensive rating, opponents have logged 111.4 PPG (13th) with a 53.4% effective field goal percentage (15th). Point totals have been elevated by Toronto playing at the seventh-quickest pace, leading to 93.9 shots per game (third).
The Nuggets, meanwhile, are playing at the ninth-slowest pace. Denver is taking only 83.7 shots per contest (27th), limiting its PPG to 113.3 (14th) despite an efficient 54.4% effective field goal percentage (12th). The Nuggets’ 112.6 offensive rating (tied for 15th) sits in the middle of the pack, while their 115.5 defensive rating sits 23rd.
Losing the possession battle has been a major flaw for Denver in the early going. That includes a 14.0% turnover-per-play rate (20th), paired with allowing a 31.9% offensive rebounding rate (29th). That’s fueling opponents to 91.2 shots per game (25th) vs. the Nuggets.
The Raptors are a nightmare matchup in both categories. They create a ton of havoc with 11.7 steals per game (second) while forcing a 17.8% turnover-per-play rate (first). Further, Toronto boasts a 32.5% offensive rebounding rate (second).
Unlike Denver, the Raptors are consistently outshooting the competition, posting 93.9 shots per game (third) while allowing only 80.9 (first).
Further contributing to a chance for an upset, Toronto averages 52.6 points in the paint per game (third-most) and has a 28.8% shooting split at the rim (10th). The Nuggets surrender a 33.7% shot distribution at the rim (third-highest) and 51.7 paint points per contest (seventh-most).
The Raptors have a pair of injury concerns, as F Kawhi Leonard (knee) is out and C Jakob Poeltl (shoulder) is questionable. However, this lineup still has quality defenders in F Scottie Barnes (104.2 defensive rating) and F Collin Murray-Boyles (106.1 defensive rating) in an attempt to slow Nuggets C Nikola Jokic.
Lock in your Raptors vs. Nuggets prediction before tipoff on PrizePicks!
Raptors F Collin Murray-Boyles vs. Nuggets: 15.5 Pts + Rebs
- Kawhi Leonard is set to miss his sixth consecutive game and will be evaluated again next week. Without Leonard on the court, Collin Murray-Boyles’ usage rate increases by +0.8%, per FantasyLabs.
- He’s tallied 23.7 minutes per game in his last three, increasing from 18.0 over his first four of the season.
- In Murray-Boyles’ past four contests, he racked up 11.8 PPG and 4.3 rebounds per game (RPG) — which combines for 16.1 points and rebounds per game.
- The second-year forward could play a major factor in controlling the interior vs. the Nuggets, as he takes 62.7% of his shots within 10 feet of the basket. Plus, his 18.6% defensive rebounding rate is in the 63rd percentile for his position.
Pick Collin Murray-Boyles + Raptors to win on PrizePicks.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Make NBA Predictions and Picks on PrizePicks
Two underdogs on the road lead our NBA predictions today. The Cavaliers’ ability to cash in 3-pointers could hold value tonight, and the Raptors’ dominance of the possession battle spells danger for the Nuggets.
Don’t wait until tipoff — make your NBA picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.
Plus, you can make your NBA predictions for the 2026-27 season, including the NBA Finals winner, win totals, the MVP winner, and more all on PrizePicks.
Stay locked in on Playbook for daily NBA predictions, picks, and news every day all the way through the 2027 NBA Finals.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state.Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results.Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
