A fantastic matchup featuring two Western Conference teams owning a combined 11-3 record takes place in Los Angeles. The Lakers (6-2) host the upstart Spurs (5-1) at Crypto.com Arena in a battle of two of the game’s young superstars.
G Luka Doncic returns to the Lakers’ lineup after missing Monday’s victory at Portland. He'll get his first 2025 look at Spurs C Victor Wembanyama, who's off to an MVP-level start.
Let’s look at the Spurs vs. Lakers prediction and picks for Wednesday night’s showdown in Los Angeles, tipping off at 10:00 p.m. ET on ESPN.
Spurs vs. Lakers Prediction, NBA Picks
- San Antonio jumped out to an impressive 5-0 start before getting tripped up at Phoenix on Sunday, 130-118.
- The Spurs put together their worst performance from 3-point range against the Suns, hitting 10-of-41 attempts for 24.4%.
- Wembanyama ranks 12th in the NBA in scoring at 26.7 points per game and second in rebounding at 13.7.
- Spurs G Stephon Castle is averaging 20.0 ppg and 6.2 rebounds per contest. The former UConn standout is making a nice jump after posting 14.7 ppg during his run to capturing the Rookie of the Year.
- The Lakers continue life without F LeBron James, who is sidelined with sciatica and looks to make his season debut later this month.
- Doncic has dominated so far with three performances of 43 or more points.
- L.A. rallied past Portland on Monday, 123-115 without Doncic and G Austin Reaves to grab their fourth consecutive victory.
San Antonio Spurs
- San Antonio compiled a defensive rating of 112.6 or lower in each of the five wins before yielding a 127.5 offensive rating to Phoenix.
- The Spurs have faced one team currently owning a winning record, beating the Heat at home last Thursday, 107-101.
- Wemby et al are tied for sixth in the NBA in FG% with the Timberwolves at 49.8% and rank fourth in net rating at +8.8.
Los Angeles Lakers
- In spite of James' absence, the Lakers have put together an impressive offensive rating of 117.7, fifth in the league.
- The Lakers have won all four of their road games, but have split their four contests at Crypto.com Arena.
- Head coach J.J. Redick’s team is scorching hot from an EFG% standpoint, sitting second behind the Bucks at 59.2%.
Spurs vs. Lakers Picks & NBA DFS
Check out tonight’s top picks for this matchup between San Antonio and Los Angeles.
Lakers G/F Luka Doncic vs. Spurs Projection: 33.5 Points
- Doncic has played in only four of L.A.’s eight games so far, but is averaging a cool 41.3 ppg.
- In his first three games, he made 14 or more field goals and shot 35.1% from 3-point range.
- He took a slight step back in his return from a three-game absence on Sunday against Miami. Doncic scored 29 points, but struggled from 3-point land, hitting 1-of-11 attempts.
- In three matchups last season against San Antonio, Doncic averaged 21.7 ppg. That was his second-lowest average against any team he faced at least twice.
- The Spurs rank fourth in the NBA in defensive field goal percentage at 44.5%. San Antonio has allowed one player to score more than 34 points this season, as Brooklyn G Cam Thomas lit up the Spurs for 41 points on October 26.
Spurs C Victor Wembanyama vs. Lakers Projection: 41.5 Pts+Rebs
- Wembanyama has increased his scoring and rebounding average each season, racking up a combined 40.4 points and rebounds per game through six games.
- During San Antonio’s 5-0 start, Wemby put up 30.2 ppg before getting held to a season-low 9 points in Sunday’s loss at Phoenix.
- Sunday also marked the first time Wembanyama didn’t grab at least 10 rebounds, as he pulled down 9 boards. The top pick of the 2023 draft averaged 14.6 rebounds in the first five games.
- In two of three games against the Lakers last season, Wemby finished below this projection. His top performance came in a home loss to L.A., scoring 28 points and snatching 14 boards.
- In three road contests, Wembanyama is averaging a combined 37.7 points and rebounds.
Lakers C Deandre Ayton vs. Spurs Projection: 13.5 Points
- Ayton took advantage of L.A.’s top three scoring options sidelined in Monday’s win at Portland. He burned his former team for 29 points on 14-of-19 shooting from the floor.
- In five of seven games this season, the top pick of the 2018 draft has scored at least 15 points.
- In three home contests, Ayton is averaging 13.6 ppg, while converting a total of one free throw.
- Ayton faced Wembanyama twice last season as a member of the Trail Blazers. In those two games, Ayton posted 17.5 ppg, including 21 points in a November defeat at San Antonio.
- He will be tested against this San Antonio team that ranks third in the league in opponent points per game allowed at 39.7.
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The Lakers and Spurs close out an exciting night of basketball in Los Angeles that should provide plenty of fireworks.
There’s never been a better time to add to the excitement of every NBA moment than with PrizePicks.
There is a wide variety of player stat projections on the NBA board, so you can build your Lineup however you’d like — with no salary or positional restrictions. Just pick at least two player stat projections to build your Lineup on PrizePicks.
Check out the Playbook throughout the remainder of the NBA season for more analysis for your PrizePicks and NBA DFS Lineups.




