Tuesday’s UEFA Nations League match between Spain and Croatia is set to kick off at 2:45 p.m. ET. Spain enters the UEFA Nations League match as significant favorites on their home pitch, with a 1.17x payout on PrizePicks.
The 2026 World Cup winners needed two second-half goals to beat England on Saturday in their first competitive match since lifting the World Cup trophy. Croatia picked up a 2-1 victory to open the international break vs. Czechia and sit level with Spain at the top of the group on three points.
Below, we'll break down our Spain vs. Croatia prediction and picks for Tuesday's UEFA Nations League match, including the Nations League winner payouts and picks for PrizePicks today.
Make your Spain vs. Croatia prediction on PrizePicks now!
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Spain vs. Croatia Prediction, Picks for UEFA Nations League – Tuesday, September 29
How to watch Spain vs. Croatia: Fox Sports 1
Kickoff Time: 2:45 p.m. ET
Venue: Ramón Sánchez Pizjuán, Seville, Spain
Spain needed a come-from-behind effort against England in their first match since winning the 2026 World Cup back in July. After conceding just 2 goals throughout their entire World Cup run, La Roja were scored on twice within a four-minute span against a dangerous English attack.
PrizePicks seems to believe Spain's defense will hold up far better against Croatia today based on the winner payout, despite Slaven Bilić's side showing a genuine attacking threat in recent fixtures.
Croatia's 2-1 win on Saturday marked the eighth straight game in which they have scored at least once, with Bilić's squad scoring multiple goals in six of those eight contests. The veteran-filled side may not enjoy as much possession or attacking success as England did in the Nations League opener, but they could still test Simón's goal after how vulnerable Spain's defense looked this weekend.
The last time these teams met in 2024, Croatia arguably matched Spain for large spells despite the 3-0 scoreline.
Bilić's side actually out-possessed one of the world's best teams at keeping the ball and generated more xG than the now world champions — 2.38 to Spain's 2.01. Croatia outshot Spain in that game and was unfortunate not to score, with a penalty saved by Simón proving costly.
Spain's form is undeniable, but it would be wrong to assume Croatia cannot compete with the world champions based on recent history between these sides.
Spain vs. Croatia Winner Payouts – Tuesday, September 29
Spain enters Tuesday’s game as home favorites against Croatia, returning a 1.17x payout if they win outright, via PrizePicks.
Meanwhile, Croatia will look to pull off a massive upset as underdogs on the road, with their 9.09x payout to win outright. PrizePicks has a 6.66x payout for a draw.
Make your Spain vs. Croatia prediction on the winner on PrizePicks!
PrizePicks data is live at the time of writing and is subject to change.
Spain vs. Croatia Prediction on Winner for UEFA Nations League - 9/29/26
Here are the key game stats and trends behind our Spain vs. Croatia prediction on the winner for the Nations League match on Tuesday, September 29.
- Spain's win on Saturday extended their winning streak to eight, extending back to a group stage draw with Cape Verde at the World Cup.
- Luis de la Fuente's side are now 39 games unbeaten across all competitions — the longest such streak in men's international football history. La Roja last lost to Colombia in a friendly back in 2024.
- Spain famously defeated Croatia in the 2023 Nations League Final, with the match going to a penalty shootout after a goalless 90 minutes.
- Croatia has lost their last three straight meetings with the world champions, with their most recent win against Spain coming back in 2018.
- Croatia's defense has been a concern since the World Cup, conceding 8 goals in their last five games with just one clean sheet in that stretch.
Lock in your Spain vs. Croatia prediction on PrizePicks before kickoff.
Spain vs. Croatia Projected Lineups – Tuesday, September 29
Take a look at the Spain vs. Croatia projected lineups for today's UEFA Nations League match. Lineups are not official and should be confirmed before match start.
Spain Lineup vs. Croatia: Projected 4-2-3-1
Goalkeeper: Unai Simón
Defense: Pubill, Pau Cubarsí, Aymeric Laporte, Marc Cucurella
Midfield: Rodri, Dani Olmo, Fabián Ruiz
Forwards: Alejandro Baena, Ferran Torres, Lamine Yamal
Croatia Lineup vs. Spain: Projected 4-2-3-1
Goalkeeper: Dominik Livaković
Defense: Ivan Smolčić, Luka Vušković, Joško Gvardiol, Ivan Perišić
Midfield: Mateo Kovačić, Josip Mišić, Petar Sučić
Forwards: Martin Baturina, Marco Pašalić, Ante Budimir
Spain vs. Croatia Player Picks, Stats for PrizePicks: 9/29/26
Here are Spain vs. Croatia picks to target for the UEFA Nations League on PrizePicks for Tuesday, September 29. Today’s UEFA Nations League picks include Lamine Yamal and Dominik Livaković.
Spain RW Lamine Yamal vs. Croatia: 4.5 Shots
- Much of both the club's and country's attacking threat runs through teenage phenom Lamine Yamal. The 19-year-old had 7 shots in Spain's Nations League opener on Saturday and 5 in his last club appearance for Barcelona before the international break.
- Yamal averaged a team-high 3.4 shots per game across Spain's eight World Cup matches and is averaging 5.4 shots in La Liga this season.
- The then-16-year-old faced Croatia in the most recent meeting between these sides in 2024, finishing with 3 total shots and an assist in the 3-0 victory.
Add Lamine Yamal to your PrizePicks lineup now!
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Croatia GK Dominik Livaković vs. Spain: 4 Goalie Saves
- Livaković will face several of his new club teammates on Tuesday afternoon. The 31-year-old faced just 5 total shots in the Nations League opener, with only 2 on target while making 1 save on the day.
- The new Barcelona signing is averaging 2.2 saves per game across his last five international appearances. The vast majority of those saves came against England during the World Cup (7), with just 1.0 saves per game in the four matches that followed.
- With an attack as potent as Spain's, Livaković can expect a busy afternoon. The world champions are averaging 6.6 shots on target per game over their last five matches.
Add Dominik Livaković to your PrizePicks lineup now!
Make Spain vs. Croatia Picks on PrizePicks
Spain will look to extend their winning streak as significant home favorites when they host Croatia on Tuesday, September 29. Croatia seeks revenge for their 2023 Nations League Final defeat against the world champions.
Don’t wait until kickoff — you can make your Spain vs. Croatia picks for Tuesday’s Nations League match now on PrizePicks to earn real money.
Just pick your Nations League players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on match winner, total goals, and both teams to score – now available in 36 states.
Stay locked in with the Playbook for continued soccer and UEFA Nations League predictions, picks, and analysis.
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