Seahawks vs. Raiders Prediction, Spread, NFL Week 10 Picks – Sunday, November 15

Sunday, November 15, brings the much-anticipated first NFL start for QB Fernando Mendoza in the Seahawks vs. Raiders at 4:05 p.m. ET on CBS. According to PrizePicks, the Seahawks are favored by 6.5 points on the spread.

Mendoza, the 2026 No. 1 overall pick, faces a tough test against the defending-champion Seahawks, who have one of the league’s best defenses. Seattle is seeking consistency with a 2-3 record over its last five games.

Below, we’ll break down our Seahawks vs. Raiders prediction, followed by player projections via PrizePicks.

Make your Seahawks vs. Raiders picks on PrizePicks now! 

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Seahawks vs. Raiders Prediction, Spread, Over/Under for NFL Week 10 – Sunday, November 15

The Seahawks are a 6.5-point road favorite with a 1.33x payout to win outright, compared to the Raiders' 3.12x payout to emerge victorious.

Here are the full payouts for the Seahawks vs. Raiders on PrizePicks, including winner payouts, the spread, and the over/under. PrizePicks data is live at the time of writing and is subject to change. ‍

Make your Seahawks vs. Raiders prediction on the spread on PrizePicks.

All stats are via NFL Next Gen Stats, FTN Fantasy, and PFF unless otherwise noted.

The Seahawks’ title defense has not gone smoothly this season. They won three of the first four games, with their only loss vs. the Commanders — who scored 33 points.

They’ve hit a rough patch recently, losing three of their last five games. In those three losses, they’ve allowed at least 30 points in two. 

The Seahawks biggest problem has been the defense hasn’t contained opponents, and that puts them at a disadvantage because the offense is struggling. In fact, Seattle is 18th in points per game (21.1), 23rd in EPA per play (-0.04), and 24th in offensive success rate (40.7%).

One reason the Seahawks could be struggling on offense is due to the injuries.

They just got RB Zach Charbonnet back from the knee injury he suffered in last season's playoffs. Plus, Seattle selected RB Jadarian Price in the first round of this past draft, but he suffered a chest injury in Week 3, was placed on IR, and recently returned.

QB Sam Darnold sustained a glute injury on the opening drive in Week 1 against the Patriots, which kept him out of Week 2 against the Cardinals. Darnold now has a quadriceps injury and will miss his second straight game today.

Seahawks QB Drew Lock has done a great job replacing Darnold, winning three games and throwing 5 TDs with 0 INTs. Now that the unit has a full complement of running backs and receivers, the offense could finally improve offensively, even with Lock at quarterback.

Seattle may not need an excellent offensive performance to win this game, though.

It could be a tough first NFL start for Raiders QB Fernando Mendoza, who faces one of the best defenses in football. This is perhaps this season’s most highly anticipated start, with Mendoza coming off winning the Heisman Trophy, the national championship, and being selected No. 1 overall in this year’s NFL Draft. 

Mendoza is fortunate to have TE Brock Bowers, one of the best at his position. Bowers is leading all tight ends with 658 receiving yards despite missing the first two games of the season.

The Raiders also need the run game to step up. They have the league's worst ground game, ranking last in yards per carry (2.9) and second-to-last in rushing success rate (31.5%).

Ideally, the Raiders want the Seahawks to stack the box to slow the run, leaving fewer defenders in coverage against a rookie quarterback. However, the Raiders rank last in yards per carry against a light box (3.4), which means the Seahawks could comfortably sit back in coverage and look to confuse Mendoza with various looks in the secondary.

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Seahawks vs. Raiders Prediction on Spread – 11/15/26

Here are the key stats and predictions behind our Seahawks vs. Raiders prediction on the spread for Sunday, November 15.

• Vegas has the NFL's worst defense, allowing a league-high 29.8 points per game. The Seahawks have performed better on the road, averaging 25.3 points per game compared to 21.0 at home.
• Seattle allows the fifth-fewest points per game in the league (18.0) and will face a rookie quarterback making his first NFL start.
• The Raiders tout one of the league's worst run games, ranking 31st in rushing yards per game (73.1). Seattle is a nightmare matchup as one of the league's top run defenses, ranking fourth in rushing yards allowed per game (89.1).
• The Seahawks have the NFL's fourth-highest pressure rate (27.0%), and Mendoza will start behind an offensive line that places 19th in pressure rate allowed (23.5%).
• Short drives for Las Vegas may be another theme. The Seahawks force the second-highest three-and-out rate in the league (29.3%), while the Raiders are 16th for offensive three-and-out rate (19.0%).

Lock in your Seahawks vs. Raiders prediction on PrizePicks!

Seahawks vs. Raiders Picks, Player Stats for PrizePicks: 11/15/26

Here are the top Seahawks vs. Raiders picks to target on Sunday, November 15. Today’s NFL picks for PrizePicks include WR Jaxon Smith-Njigba and RB Ashton Jeanty.

Seahawks WR Jaxon Smith-Njigba vs. Raiders: 7.5 Receptions

• Jaxon Smith-Njigba leads the league in target rate (36.1%).
• The Raiders have allowed 7 or more receptions to a wide receiver in two of their last three games.
• JSN could come close to this projection before halftime. He’s had 6 or more first-half receptions in two of his last three games.
• The Raiders have faced two other wide receivers who rank in the NFL's top 10 for receptions. Rams WR Puka Nacua (fourth) had 8 receptions in Week 7, and Saints WR Chris Olave (seventh) had 9 receptions in Week 3.
• The Raiders struggle to defend wide receivers lined up outside, which will help JSN. Smith-Njigba lines up on the outside on 73.8% of his snaps. According to Sharp Analytics, the Raiders are 22nd in yards allowed per catch to outside wide receivers (9.1).

Add Jaxon Smith-Njigba + Seahawks to your PrizePicks lineup now.

Raiders RB Ashton Jeanty vs. Seahawks: 33.5 Rush Yards

• Jeanty is having a disappointing second year and has rushed for fewer than 30 yards in five consecutive games.
• The Seahawks yield the eighth-fewest rushing yards to running backs this season (629).
• Among the 25 players with at least 100 carries this season, Jeanty has the fewest rushing yards (362).
• The Seahawks do well at keeping rushers behind the line of scrimmage thanks to their 24.4% stuff rate, the fifth-highest in the league. Jeanty ranks only 42nd in stuffed rate (25.4%).

Add Ashton Jeanty + Raiders to your PrizePicks lineup now.

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Make Seahawks vs. Raiders Picks on PrizePicks

The Seahawks have hit a rough patch, losing three of their last five games. They hope to show off in a big way against the Raiders in Fernando Mendoza's first NFL start.

Don’t wait until kickoff — make your Seahawks vs. Raiders picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.

With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.

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