Saints vs. Ravens is set for kickoff at 1:00 p.m. ET on Sunday, September 20, with the Ravens listed as 7.5-point favorites, via PrizePicks.
The Ravens are coming off a dominant 41-23 win over the Colts in Week 1 in which RB Derrick Henry recorded 3 TDs. The Saints were also involved in a high-scoring affair when they suffered a 31-30 overtime loss to the Lions in Detroit.
Below, we’ll break down our Saints vs. Ravens prediction and picks for NFL Week 2, including the spread, over/under, and key player picks for PrizePicks.
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Saints vs. Ravens Prediction, Spread, Over/Under – Sunday, September 20
The Saints and Ravens used different ways to each reach 30 points in Week 1.
The Ravens leaned heavily on Henry, who had 23 rush attempts. Ravens QB Lamar Jackson was only asked to attempt 25 passes. Saints QB Tyler Shough threw 56 passes with New Orleans trying to claw back from an early deficit, leaving RB Travis Etienne Jr. to only receive 9 rush attempts.
The Saints should receive a boost to their offense in Week 2 with RB Alvin Kamara (knee) trending towards making his season debut. Saints WR Chris Olave (hamstring) left practice early Thursday but is still expected to play.
The injury news isn’t as good for the Ravens, who placed rookie WR Ja’Kobi Lane (wrist) on IR. Ravens WR Zay Flowers is also dealing with a hamstring injury that has prevented him from practicing, putting his status in doubt for Sunday.
Saints vs. Ravens Spread, Over/Under for Week 2 – Sunday, September 20
The Ravens enter Sunday’s game as a 7.5-point home favorite against the Saints, via PrizePicks.
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PrizePicks data is live as of writing and is subject to change.
Saints vs. Ravens Prediction on Over/Under – Sunday, September 20
Here are the key game stats and trends behind our Saints vs. Ravens prediction on the over/under for Sunday, September 20.
- The Saints have been a more competent offensive team since Shough took over as their starting quarterback. Over their final five games of 2025, they scored at least 24 points three times.
- New Orleans’ dynamic WR duo of Olave and DeVaughn Vele combined for 17 receptions for 251 yards and 1 TD against the Lions.
- The Ravens tend to dominate on the ground behind Henry, ranking third in Rush EPA last season, per RBSDM.
- Dating back to last season, Henry has five straight games with at least 100 rushing yards. In three of those matchups, he came away with at least 2 TDs.
- The Saints were just torched by an elite running back last week, allowing Lions RB Jahmyr Gibbs to run for 156 yards and 2 TDs on 29 carries.
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Saints vs. Ravens Picks, Player Stats for PrizePicks: 9/20/26
Here are top Saints vs. Ravens picks to target on PrizePicks for Sunday, September 20. Week 2 NFL picks for PrizePicks include WR Devaughn Vele and RB Derrick Henry.
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Saints WR Devaughn Vele vs. Ravens: 41.5 Receiving Yards
- Vele received 9 targets against the Lions, finishing with 7 receptions for 69 yards and 1 TD. Per PFF, he ran 58 routes.
- Following the Saints’ bye in Week 11 last season, Vele received at least 6 targets in three of four games before suffering a season-ending injury.
- New Orleans continues to play without first-round pick WR Jordyn Tyson (hamstring), who is on IR and will miss at least three more games.
- With teams often needing to throw to keep up with the Ravens’ high-powered offense last season, their defense allowed the second-most receptions to wide receivers (221), per RotoWire.
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Ravens RB Derrick Henry vs. Saints: 92.5 Rush Yards
- In his first two seasons with the Ravens, Henry averaged 5.9 and 5.2 yards per carry.
- The veteran running back has been a workhorse for Baltimore, receiving at least 307 rush attempts in the last two seasons with the franchise.
- Henry finished third among running backs in explosive runs (36) last season.
- The Saints could be missing a key defender in DE Cameron Jordan, who sat out Week 1 with his hamstring injury. He was a limited participant in Thursday’s practice.
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After both teams thrived on offense in Week 1, we could see plenty of points when the Ravens host the Saints in Week 2. Henry has the potential to dominate on the ground again, while Vele could continue to benefit from the absence of Tyson.
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