Red Sox vs. Athletics Prediction, MLB Picks for Monday, July 27

Red Sox vs. Athletics is set for first pitch at 9:40 p.m. ET on Monday, July 27, with the Red Sox favored and returning a 1.51x payout if they win, via PrizePicks.

The Red Sox aim to continue their push towards a playoff spot with SP Payton Tolle (5-6, 3.31 ERA) on the mound. The Athletics will deploy their own young hurler in SP Jack Perkins (2-5, 6.75 ERA). These two pitchers have combined to throw 207.1 career innings in the majors.

Below, we’ll break down our Red Sox vs. Athletics prediction and picks for Monday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Red Sox vs. Athletics Prediction, Winner Payout, Over/Under – Monday, July 27

The Red Sox were a disappointment during the first half of the season, mainly because of their lineup. As they have worked themselves back into the playoff picture, they've come alive at the plate.

Boston averages 4.2 runs per game for the season but has put up 5.3 runs each time out since returning from the All-Star break. Over the weekend, they helped fortify their lineup for the stretch run by acquiring INF Curtis Mead in a trade with the Nationals.

While things are trending up for the Red Sox, the same can’t be said for the Athletics, who have lost four of their last five games. Injuries have hit their lineup, which has been the strength of their team.

Star C Shea Langeliers, who has 23 home runs and 51 RBI, is on the injured list with a torn meniscus that could end his season.

Red Sox vs. Athletics Winner Payout, Over/Under – Monday, July 27

The Red Sox enter Monday’s game as a road favorite against the Athletics, returning a 1.51x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Red Sox vs. Athletics game on PrizePicks Team Picks — where you can make real-money predictions on every MLB game!

Make your Red Sox vs. Athletics prediction on spread or over/under on PrizePicks Team Picks — available in 36 states!

Team Picks data is live as of writing and is subject to change.

Red Sox vs. Athletics Prediction on Winner – Monday, July 27

Here are the key game stats and trends behind our Red Sox vs. Athletics prediction on the winner for Monday, July 27.

• The Red Sox have been better on the road (29-21) than at home (25-29).
• The Athletics have the fewest home wins (20) in baseball.
• Boston has a +46 run differential, compared to a -125 mark for the Athletics.
• The Red Sox have a significant advantage to end games. Their bullpen has a 3.05 ERA and a 1.17 WHIP; the A’s bullpen has a 5.53 ERA and a 1.50 WHIP.
• Perkins has problems keeping hitters inside the ballpark, giving up 15 home runs over 101.1 career innings in the majors.

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Red Sox vs. Athletics Picks, Player Stats for PrizePicks: 7/27/26

Here are top Red Sox vs. Athletics picks to target on Monday, July 27. Today's MLB picks for PrizePicks include SP Jack Perkins and 1B Willson Contreras.

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SP Jack Perkins vs. Red Sox: 2.5 Earned Runs Allowed

• Perkins allowed at least 3 earned runs in seven of his last eight outings. During that span, he had a 7.79 ERA and a 1.59 WHIP.
• Across his last 34.2 innings, the young righty has issued 17 walks and allowed 10 home runs.
• According to FanGraphs, Perkins has ceded a .358 wOBA and has a 1.56 WHIP at home. On the road, those respective figures are .318 and 1.26.
• The Red Sox have a .718 OPS on the road versus a .694 OPS at home.

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Red Sox 1B Willson Contreras vs. Athletics: 6.5 Hitter Fantasy Score

• Contreras has a .401 wOBA that is on pace to be the highest mark of his career. He's paired it with a .259 ISO, largely thanks to his 22 home runs.
• The former St. Louis Cardinal has a 14.4% barrel rate, which is an increase over his career mark of 11.1%.
• Per Baseball Savant, Perkins throws his four-seamer 36.4% of the time, more than any other offering. Opponents are batting .275 against that pitch, and Contreras is hitting .326 when facing fastballs in 2026.
• Contreras has a 156 wRC+, tied for the fourth-highest in the majors.

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Make Red Sox vs. Athletics Picks on PrizePicks

The Red Sox look to stay hot on the road in the first game of their series with the Athletics. Perkins has the potential to get hit hard again at home, especially with Contreras leading the way for Boston.

Don’t wait until first pitch — make your Red Sox vs. Athletics picks on PrizePicks now and earn real money if you’re right.

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