Tuesday’s Champions League match between Real Madrid and Inter Milan is set to kick off at 3:00 p.m. ET. Real Madrid enters the opening Champions League match as solid favorites on their home pitch, with a 1.56x payout to win on PrizePicks.
Real Madrid and Inter Milan meet in the Spanish capital in both clubs' Champions League opener. Tuesday's match could serve as an early indicator of just how serious a threat each poses in this season's competition.
Below, we'll break down our Real Madrid vs. Inter Milan prediction and picks for Tuesday's Champions League match, including the UCL winner payouts, total goals, and top Champions League picks for PrizePicks today.
Make your Real Madrid vs. Inter Milan picks on PrizePicks now!
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Real Madrid vs. Inter Milan Prediction, Picks for Champions League – Tuesday, September 8
How to watch Real Madrid vs. Inter Milan: Paramount+ (English) / UniMás (Spanish)
Kickoff Time: 3:00 p.m. ET
Venue: Bernabéu, Madrid, Spain
The Champions League returns on Tuesday afternoon, and two of the competition's most storied clubs meet in the Spanish capital. Real Madrid host Inter Milan in a fixture that brings these sides together in the competition for the first time since 2021.
Los Blancos will look to add to their record 15 European titles after several years of falling short in the Champions League. Inter Milan, meanwhile, hope to claim their fourth European title this season after reaching the final in 2023, only to suffer back-to-back Round of 16 eliminations.
Real Madrid come into the match having dropped their first game of the season on Friday to Real Betis. Before that, Los Blancos had won their opening three games under new manager José Mourinho, scoring 10 goals in the process.
They now attempt to bounce back against the reigning Serie A champions, who have won all three of their league games to open the season. Inter have shown real resilience early on, coming from 2-0 down in the second half to win 3-2 in their most recent outing.
Inter may need more late-game heroics on Tuesday as they arrive as significant underdogs.
After a busy and ambitious summer, Real Madrid enter with high expectations both domestically and in Europe. PrizePicks has them favored in their Champions League opener and as the third-favorite to win the competition this season, with a 5.55x payout to lift the trophy.
Real Madrid vs. Inter Milan Spread, Total Goals, Payouts – Tuesday, September 8
Real Madrid enters Tuesday’s game as home favorites against Inter Milan, returning a 1.56x payout if they win outright, via PrizePicks.
Meanwhile, Inter Milan will look to pull off a massive upset as underdogs on the road, featuring a 4.54x payout to win. A draw returns a 3.7x payout on PrizePicks.
Here are the full payouts for the Real Madrid vs. Inter Milan game on PrizePicks.
Make your Real Madrid vs. Inter Milan prediction on total goals on PrizePicks.
PrizePicks data is live at the time of writing and is subject to change.
Real Madrid vs. Inter Milan Prediction on Total Goals – 9/8/26
Here are the key game stats and trends behind our Real Madrid vs. Inter Milan prediction on the total goals for the Champions League match on Tuesday, September 8.
Check out more of our Champions League picks and predictions on PrizePicks.
- Real Madrid games have finished over 3.5 goals in two of four La Liga games this season. Two of Inter Milan’s three Serie A games have finished over that total as well.
- These teams met in the UCL group stage in 2020 and 2021, with just one of four games surpassing 3.5 total goals.
- Real Madrid are averaging 2.5 goals per game and creating 4.8 big chances per game in La Liga. They averaged 2.4 goals per game with just 3.9 big chances per contest in last year’s UCL campaign.
- Inter Milan conceded 1.0 goal per game in Serie A and 1.2 goals per game in the Champions League last season.
- Real Madrid was held without a goal for the first time this season in their most recent game vs. Real Betis. Los Blancos finished the match with 20 total shots and 3.46 xG, per FotMob.
Lock in your Real Madrid vs. Inter Milan prediction on PrizePicks before kickoff!
Real Madrid vs. Inter Milan Projected Lineups for Champions League – Tuesday, September 8
Take a look at the Real Madrid vs. Inter Milan projected lineups for today's Champions League match. Lineups are not official and should be confirmed before match start.
Real Madrid Lineup vs. Inter Milan: Projected 4-1-2-3
Goalkeeper: Thibaut Courtois
Defense: Denzel Dumfries, Ibrahim Konaté, Dean Huijsen, Marc Cucurella
Midfield: Federico Valverde, Brahim Díaz, Jude Bellingham
Forwards: Yan Diomandé, Kylian Mbappé, Vinícius Jr.
Inter Milan Lineup vs. Real Madrid: Projected 3-5-2
Goalkeeper: Josep Martínez
Defense: Alessandro Bastoni, Yann Bisseck, Manuel Akanji
Midfield: Carlos Augusto, Curtis Jones, Hakan Çalhanoğlu, Nicolò Barella, Andy Diouf
Forwards: Marcus Thuram, Lautaro Martínez
Real Madrid vs. Inter Milan Picks, Player Stats for PrizePicks: 9/8/26
Here are Real Madrid vs. Inter Milan picks to target for the Champions League on PrizePicks for Tuesday, September 8. Today’s UCL picks include Kylian Mbappé and Josep Martínez.
Real Madrid ST Kylian Mbappé vs. Inter Milan: 2.5 Shots on Target
- Mbappé leads La Liga with 4.5 shots on target per game this season. The Frenchman is averaging just under 8 total shots per game, with more than half finding the target.
- Last season's UCL Golden Boot winner averaged 2.7 shots on target across 11 Champions League appearances, finishing the campaign with 15 goals on 10.79 xG.
- France's all-time leading scorer has registered 3 or more shots on target in all four of his La Liga games this season. Inter Milan conceded 7 shots on target to their most recent Serie A opponent on Saturday.
Add Kylian Mbappé to your PrizePicks Champions League lineup now!
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Inter Milan GK Josep Martínez vs. Real Madrid: 4 Goalie Saves
- Martínez has experienced a relatively quiet start to the season, averaging 2.7 saves per game and saving 73% of shots faced across his first three Serie A appearances
- In the most recent game vs. Napoli, he tallied 6 of his 8 saves for the season. That means Martínez had made just 2 saves combined in his first two outings.
- Martínez faces his toughest test yet with Real Madrid, averaging 19.5 shots per home game this season — 9.5 of which have been on target.
Add Josep Martínez to your PrizePicks Champions League lineup now!
Make Real Madrid vs. Inter Milan Picks con PrizePicks
Real Madrid are searching for a 2026-27 Champions League home win when they host Inter Milan on Tuesday, September 8, at 3:00 p.m. ET. The reigning Serie A champions seek to defy the odds and come away with a result in Spain.
Don’t wait until kickoff — you can make your Real Madrid vs. Inter Milan picks for Tuesday’s Champions League match now on PrizePicks to earn real money.
Just pick your Champions League players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on match winner, total goals, and both teams to score — now available in 36 states.
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