The Tampa Bay Rays (18-11) and Cleveland Guardians (15-16) both look to finish their three-game series on a high note on Wednesday, April 29 at 1:10 p.m. ET. On PrizePicks Team Picks, the Guardians return a 1.78x payout to earn the win.
Tampa Bay has an opportunity to achieve the sweep after defeating Cleveland by a combined score of 4-2 in the first two matchups. There are potential weather concerns for Wednesday’s contest, so keep tabs on any updates before the game begins.
Below, we'll break down our Rays vs. Guardians prediction and picks for Wednesday’s MLB showdown, including the spread, over/under, and key player picks for PrizePicks.
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Rays vs. Guardians Prediction, Spread, Over/Under – Wednesday, April 29
It will be the Rays’ Drew Rasmussen (3.02 xFIP across 5 starts and 25.2 IP in 2026) and the Guardians’ Gavin Williams (3.50 xFIP in 6 starts and 35.2 IP) on the mound in the series finale on Wednesday.
The underlying metrics have been fantastic for Rasmussen, ranking in the 88th percentile in xERA (2.65), 73rd percentile in strikeout rate (26.5%), and 96th percentile in walk rate (4.1%), per Baseball Savant.
Tampa Bay’s lineup has been an above-average unit to begin the 2026 MLB season, logging the 13th-best wRC+ (100), 10th-best wOBA (.322), and lowest strikeout rate (18.6%), via FanGraphs. However, the Rays are hoping that 3B Junior Caminero doesn’t miss much time after fouling a ball off his face early in Tuesday’s outing.
Although Williams is in the 82nd percentile in xBA (.202) and 90th percentile in strikeout rate (31.0%), there are potential concerns. He sits in the 50th percentile in xERA (4.11) and 21st percentile in walk rate (13.4%).
Cleveland’s bats have struggled to display consistency, recording the ninth-worst wRC+ (94), sixth-worst wOBA (.309), and 12th-worst ISO (.146) in the league to begin the new campaign.
Rays vs. Guardians Spread, Over/Under – Wednesday, April 29
The Guardians enter Wednesday’s game as home favorites, returning a 1.78x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Rays vs. Guardians game on PrizePicks.
- Spread: Tampa Bay Rays -1.5 (2.7x payout)
- Over/Under: 6.5 (1.78x payout on Over)
- Game Winner Payout: Rays 1.92x | Guardians 1.78x
Play the Rays vs. Guardians spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Rays vs. Guardians Prediction on Over/Under – 4/29/26
Here are the key game stats and trends behind our Rays vs. Guardians prediction on the total runs for Wednesday, April 29.
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- Each of the first two games in this series has had 5 or fewer total runs scored.
- Rasmussen has given up more than 1 ER in only one of his five starts, and he’s in the 77th percentile in xBA (.211) and 73rd percentile in groundball rate (50.0%).
- While Williams did surrender 6 ER in his last start, he’s permitted 2 or fewer ER in four of his six outings.
- The Guardians are tallying the eighth-worst wRC+ (91), sixth-worst wOBA (.305), and 11th-worst ISO (.145) against right-handed pitching. Cleveland had the fourth-worst wRC+ (90), fourth-worst wOBA (.296), and 11th-worst ISO (.154) in that split in 2025.
- Both bullpens have been mostly reliable, as the Rays’ relievers have accrued the eighth-best xERA (3.85) and sixth-best WHIP (1.23). Meanwhile, the Guardians’ bullpen has the third-best xERA (3.63) and fifth-best WHIP (1.23).
- Cleveland is currently on a four-game losing streak and has failed to score more than 3 runs in any of those contests.
- When playing at home last season, the Guardians had the 14th-lowest rate on hitting the over (47.5%).
- Meanwhile, the Rays were tied for the 11th-lowest rate on achieving the over (47.4%) when operating as the road team in 2025.
Rays vs. Guardians Player Picks, Stats for PrizePicks: 4/29/26
Here are the top Rays vs. Guardians picks to target on PrizePicks for Wednesday, April 29. Today’s MLB picks for PrizePicks include CF Cedric Mullins and SP Drew Rasmussen.
Rays CF Cedric Mullins vs. Guardians Projection: 5 Hitter Fantasy Score
- Cedric Mullins has gotten off to a slow start this season, notching a woeful 17 wRC+, .199 wOBA, and .110 ISO across his first 101 PAs.
- Mullins has gone hitless in five straight games, and he’s struck out at least once in seven of his last 10 appearances.
- Even though it’s still early, Williams is producing reverse splits on the mound, registering a 3.37 xFIP and 0.94 WHIP against lefties in 2026. He has a 3.71 xFIP and 1.33 WHIP when facing righties.
- Just last season, Mullins had an 85 wRC+, .287 wOBA, and 27.0% strikeout rate vs. right-handed pitchers. He had a 121 wRC+, .341 wOBA, and 15.9% strikeout rate against lefties.
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Rays SP Drew Rasmussen vs. Guardians Projection: 1.5 Walks Allowed
- As mentioned, Rasmussen owns just a 4.1% walk rate to begin the 2026 campaign.
- Furthermore, Rasmussen hasn’t had a walk rate higher than 6.3% in each of the last four campaigns.
- Over his first five starts, Rasmussen has issued more than a single walk in only one of those outings.
- Thus far in 2026, the Guardians have the 13th-lowest walk rate (8.3%) in the league.
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Runs have been tough to come by in the Rays-Guardians series, and we have Drew Rasmussen and Gavin Williams on the mound for Wednesday’s bout. Will Tampa Bay complete the sweep, or can Cleveland salvage a win?
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