Pistons vs. Lakers Prediction, Tuesday NBA Picks: Back Cade Cunningham in L.A.?

Detroit Pistons PG Cade Cunningham celebrates during a game against the Brooklyn Nets.
AP Photo/Heather Khalifa

Tuesday brings a somewhat light NBA slate, but one of the four matchups is a heavy-hitter between the East and West. At 10:30 p.m. ET, the Pistons and Lakers tip off from Los Angeles on NBC and Peacock.

Off to a roaring 24-8 start, Detroit has shocked the basketball world and currently sits first in the Eastern Conference. In the Western Conference, L.A. is just 5-5 in its last 10 but still occupies the fifth spot in the standings thanks to a 20-10 overall record. Tuesday’s game is critical for both sides, even with it being an inter-conference bout. 

Below, we’ll break down a Pistons vs. Lakers prediction and picks to consider for Tuesday night’s game. Make your picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right. 

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Pistons vs. Lakers Prediction, Spread, Over/Under

Tuesday marks the 351st meeting between the Pistons and Lakers. Despite Detroit winning two in a row in this series, Los Angeles boasts a commanding 214-136 lead

On the injury front, the Pistons list G Caris LeVert as day-to-day with a knee injury. The Lakers, meanwhile, will be without PG Gabe Vincent (back) and SG Austin Reaves (calf), with F Rui Hachimura (calf) day-to-day. 

Pistons vs. Lakers Over/Under, Spread

The Pistons enter Tuesday’s game as 3.5-point road favorites, returning a 1.69x payout on PrizePicks Team Picks if they win outright.

The Lakers are home underdogs with a 2.04x payout if they win, via PrizePicks Team Picks.

  • Spread: Detroit Pistons -3.5
  • Over/Under: 231.5
  • Game Winner Payout: Pistons 1.69x | Lakers 2.04x

Team Picks data is live at the time of writing and is subject to change.

Pistons vs. Lakers Prediction on Spread

Here are some stats to know to get you prepared for Pistons vs. Lakers.

  • While the Lakers are 17-13 against the spread this season, Detroit remains a solid 17-15, good for a 53.1% cover rate.
  • Los Angeles is just 2-3 as a home underdog, making their 40% cover rate in such scenarios the fifth-worst share in the sport. 
  • Detroit’s +6.0 average scoring margin is sixth, and they sit top 10 in shooting percentage on both offense (47.8, eighth) and defense (44.5, second). 
  • Los Angeles’ +0.3 scoring margin is by far the worst of any projected playoff team in the West.
  • Head coach JJ Redick’s crew is middle-of-the-pack in per-game scoring on offense (117.2, 13th) and defense (116.9, 17th). 

Pistons vs. Lakers NBA Picks, Stats for PrizePicks Today

Here are three top Pistons vs. Lakers picks to target on Tuesday. Key PrizePicks player projections are headlined by PG Cade Cunningham, C Jalen Duren, and F LeBron James.

Pistons PG Cade Cunningham vs. Lakers Projection: 41.5 Pts + Rebs + Asts

  • In 29 games this year, Cunningham averages a combined 42.4 points, rebounds, and assists. 
  • The former top draft pick has been excellent from midrange, making 46.4% of his tries from 10-16 feet and 51.3% of his attempts from 16 feet to the 3-point line. 
  • Cunningham’s 3.6% offensive rebounding clip is the highest of his career through five seasons.
  • In his last seven outings, the former Oklahoma State standout netted 11.1 assists per night.
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Pistons C Jalen Duren vs. Lakers Projection: 28.5 Pts + Rebs

  • Duren is having a career breakout in year four, setting personal bests for points per game (18.2) while managing to grab 10.9 boards a night as well.
  • Despite that, the bouncy big man’s 20.8% rebounding clip marks a decline from 2023 (22.2%) and 2024 (22.0%). 
  • The Lakers’ defense ranks 12th in per-game paint scoring (48.8 PPG), fifth in offensive rebounds allowed (10.9) and second in defensive rebounds yielded (29.5). 
  • Per FantasyPros, Los Angeles surrenders the fewest points (17.21) and second-fewest rebounds (12.68) to the C position every game. 

Lakers F LeBron James vs. Pistons Projection: 28.5 Pts + Asts

  • Since making his debut, James averages 27.2 points and assists. In his last eight games, that number is up to 31.3. 
  • In his first eight games of the season, The King had a 22.9% usage rate. Over the next six, that spiked to 30.9%. 
  • Per databallr, James’ 26.1 shot attempts per 100 put him in the 87th percentile. 
  • Despite his on-ball percentage dropping from 31% to 18% year-over-year, LBJ’s 3.4 potential assists per minute on-ball are a career-high, via NBARAPM.

Make Pistons vs. Lakers Picks on PrizePicks

Pistons vs. Lakers isn’t the only avenue basketball fans have to make NBA picks. 

You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states. 

Stick around with the Playbook for continued NBA predictions, picks, and news.


Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

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about the author

Jordan Foote is a seasoned sports writer with years of experience covering the NFL, NBA and MLB for multiple outlets. He is a Baker University alumnus, earning his degree in Mass Media with an emphasis in sports journalism. Foote was born and raised in Kansas City, where he still resides to this day.

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