Oklahoma State vs. TCU Prediction on Spread for Wednesday, March 11

To conclude Big 12 Tournament action on Wednesday, March 11, the Oklahoma State Cowboys (19-13) take on the TCU Horned Frogs (21-10). Tip-off is scheduled for 9:30 p.m. ET on ESPNU.

According to the NCAA Net Rankings, Oklahoma State ranks 77th and TCU is 41st. The Cowboys may have work to do if they want to secure a spot in the upcoming NCAA Tournament.

Ahead of the Big 12 matchup on Wednesday, March 11, who comes out on top in our Oklahoma State vs. TCU prediction on the spread? Make your Big 12 tournament picks on PrizePicks Team Picks, where you can earn real money on game winners, spreads, and over/under predictions.

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Oklahoma State vs. TCU Prediction, Spread, Over/Under

Entering Wednesday’s showdown, TCU has gone 6-1 vs. Oklahoma State in the last seven head-to-head meetings. This season, the Cowboys suffered three-point defeats to the Horned Frogs on both February 14 and January 20.

Despite taking down Colorado on Tuesday to earn a date against TCU in the second round of the Big 12 Tournament, Oklahoma State has gone 3-7 outright and 4-6 against the spread (ATS) in the last 10 games. TCU is 8-2 outright and 7-3 ATS in the same span.

Oklahoma State vs. TCU Spread, Over/Under

TCU is favored by 3.5 points vs. Oklahoma State and returns a 1.47x payout on PrizePicks Team Picks if it wins outright.

Oklahoma State possesses a 2.56x payout if it secures a win, via PrizePicks Team Picks where you can earn money with your picks in 35 states.

• Spread: TCU Horned Frogs -3.5
• Over/Under: 156.5
• Game Winner Payout: Oklahoma State 2.56x | TCU 1.47x

Team Picks data is live at the time of writing and is subject to change.

Oklahoma State vs. TCU Prediction on Spread – March 11, 2026

Here are the key stats to know before locking in your Oklahoma State vs. TCU prediction on the spread for Wednesday, March 11, on PrizePicks.

• On the season, Oklahoma State is 9-10 ATS when facing conference opponents. TCU is 11-7 ATS vs. Big 12 foes.
• In Bart Torvik’s rankings, TCU is 28th in adjusted defensive efficiency (99.5) and 21st in defensive turnover rate (20.1%), while Oklahoma State is 140th in offensive turnover rate (16.1%).
• With the Horned Frogs not playing on Tuesday (the Cowboys did), it’s worth noting that Oklahoma State is 0-7 ATS with a rest disadvantage.
• TCU has won eight of its last nine games outright.
• Of those eight wins, six have been decided by at least four points.

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Make Oklahoma State vs. TCU Picks on PrizePicks

Oklahoma State and TCU have produced different results recently, but the Cowboys aim to pull off the upset to stay alive in the Big 12 Tournament.

Make your Oklahoma State vs. TCU picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states. 

Stick around with the Playbook for continued college basketball predictions, picks, and news all the way through the NCAA Tournament.