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Following a heartbreaking overtime defeat to the Buffalo Bills in Week 5, the Los Angeles Rams will host the Arizona Cardinals in Week 6 on Sunday, October 18, at 4:05 p.m. ET. Within this NFC West matchup, WRs Davante Adams and Michael Wilson are viable players to use in fantasy football.
Adams and Wilson are held in similar regard in most fantasy football rankings entering Week 6, so which player should you prioritize in lineups?
Below, we’ll break down a Week 6 Start 'Em, Sit 'Em discussion on whether to start Adams or Wilson in fantasy football (factoring in PPR scoring settings). We'll also highlight their Sunday PrizePicks projections.
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Start ‘Em, Sit ‘Em WRs, Week 6: Davante Adams or Michael Wilson?
Let’s dive into our Week 6 fantasy football Start ‘Em, Sit ‘Em decision between Adams and Wilson.
All stats used in this article are from PFF or SumerSports unless stated otherwise. Fantasy rankings and fantasy point totals are courtesy of FantasyPros.
Why Start Davante Adams?
Davante Adams Week 6 PrizePicks Projections: 57.5 Rec Yards, 4.5 Recs, 7 Rec Targets, 13 Fantasy Score
- Adams enters Week 6 as the WR9 in fantasy points per game (19.0), scoring at least 20 fantasy points in three of his last four outings.
- Among 43 WRs with 25 or more targets in 2026, Adams has the fifth-most yards per reception (16.3) and 16th-most yards per route run (2.17).
- Across the first five weeks, Adams leads the Rams in red-zone target share (28.0%) and red-zone receiving TDs (3).
- The Cardinals’ defense is 31st in dropback EPA (0.37) and 25th in dropback success rate (48.7%) allowed, per RBSDM.
- Plus, Arizona’s defense is giving up the fourth-most fantasy PPG to WRs (32.4) this season.
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Why Start Michael Wilson?
Michael Wilson Week 6 PrizePicks Projections: 58.5 Rec Yards, 5.5 Recs, 8.5 Rec Targets, 13.5 Fantasy Score
- Since Week 3, Wilson is the WR17 in fantasy PPG (16.6).
- Wilson has the second-highest target share (26.2%) on the Cardinals, trailing only TE Trey McBride (28.7%).
- McBride is also the only other player in Arizona’s offense to have a higher red-zone target share than Wilson (23.7%).
- Of the 43 WRs with 25+ targets this year, Wilson is tied with WR Malik Nabers with the seventh-most receptions (29).
- The Cardinals are double-digit underdogs against the Rams, which could increase the number of passing plays for Arizona’s offense if it falls behind.
Pick Michael Wilson and Cardinals to win for higher payouts on PrizePicks!
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Week 6 Start ‘Em, Sit ‘Em Verdict: Start Davante Adams
While Adams has to contend with WR Puka Nacua for targets in the Rams’ aerial attack, his red-zone role and big-play ability are extremely valuable. That could turn out to be especially true against a Cardinals defense that continues to be torched by opposing WRs.
As for Wilson, he’ll see plenty of CBs Trent McDuffie and Jaylen Watson in coverage on Sunday. McDuffie and Watson have combined to allow only 11 receptions on 30 targets (36.7% catch rate), also logging 6 pass breakups and 2 INTs between them.
With the Rams permitting the 10th-fewest fantasy PPG to WRs (24.0), Adams gets the nod over Wilson in Week 6 for fantasy football.
Make 2026 NFL Predictions on PrizePicks
Both Adams and Wilson have been mainstays in fantasy football lineups. However, if you’re stuck deciding between the two, Adams seems to be in a better spot against the Cardinals.
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