Just like that, the NFL season is off and rolling into Week 2. We have a ton of fascinating battles this weekend and will break down over 15 individual player matchups for you to take advantage of.
The Week 2 cheat sheet is your ultimate resource for the top player picks for PrizePicks NFL, matchups to target, and game insights for the slate.
Ready to lock in your NFL Week 2 predictions? Just go to the PrizePicks NFL board, pick your players, and predict if they’ll have More or Less than their projected stats to earn cash if you're right.
Make your NFL Week 2 picks on PrizePicks now!
{{nfl_offer_banner="/style-system/ui-components-playbook"}}
NFL Week 2 Cheat Sheet, NFL DFS Predictions – Sunday, September 20
Find the top NFL Week 2 predictions, picks, matchups, and players to target below in the PrizePicks cheat sheet, including analysis on QBs, RBs, WRs, TEs, and TD scorers.
NFL Week 2 Cheat Sheet: Quarterbacks
Chiefs QB Patrick Mahomes vs. Colts – 221.5 Pass Yards
The Colts allowed the second-most passing yards in the NFL in 2025 (247.9 per game) and ranked near the bottom of the league in explosive-pass prevention.
Packers QB Jordan Love vs. Jets – 254.5 Pass Yards
The Jets ranked dead last in passing EPA allowed in 2025, per RBSDM, while Love finished among the NFL's most efficient deep-ball QBs, making this a strong matchup for Green Bay's vertical passing game.
Commanders QB Jayden Daniels vs. Cowboys – 221.5 Pass Yards
Dallas allowed the second-most passing yards per game in 2025 (251.5) and ranked near the bottom of the league in explosive pass rate allowed.
Saints QB Tyler Shough vs. Ravens – 231.5 Pass Yards
Baltimore allowed production to the tune of a top-10 passing EPA in 2025, but its defense surrendered explosive completions at a much higher rate than the league's elite units.
The volume very well could be there for Shough, who threw for over 400 yards on 56 attempts last week.
Rams QB Matthew Stafford vs. Giants – 242.5 Pass Yards
The Giants ranked 25th in passing success rate allowed in 2025 and gave up 250.8 passing YPG.
Make NFL Week 2 QB picks on PrizePicks now!
NFL Week 2 Cheat Sheet: Running Backs
Ravens RB Derrick Henry vs. Saints – 93.5 Rush Yards
New Orleans ranked 30th in EPA/rush allowed in 2025 and surrendered 4.8 yards per carry. Henry already handled 24 carries for 144 yards in Week 1.
Falcons RB Bijan Robinson vs. Panthers – 83.5 Rush Yards
Carolina ranked 27th in EPA/rush allowed in 2025, surrendered 4.8 YPC, and gave up 291 yards on the ground last week. Robinson enters Week 2 after commanding 21 carries as the sole offensive focal point for the Falcons.
Eagles RB Saquon Barkley vs. Titans – 79.5 Rush Yards
Tennessee ranked 31st in rushing success rate ceded a year ago and surrendered 4.9 YPC, giving Barkley a favorable matchup.
Cowboys RB Javonte Williams vs. Commanders – 74.5 Rush Yards
Washington ranked 28th in EPA/rush allowed last season and surrendered 2,411 rushing yards overall. Williams handled 15 carries in Dallas' opener.
Buccaneers RB Bucky Irving vs. Browns – 63.5 Rush Yards
Cleveland gave up over 200 yards on the ground last week, while Irving averaged 5.6 YPC in Week 1 and could be playing from ahead in this one.
Make NFL Week 2 RB picks on PrizePicks now!
{{nfl_offer_banner="/style-system/ui-components-playbook"}}
NFL Week 2 Cheat Sheet: Receivers
Rams WR Puka Nacua vs. Giants – 85.5 Rec Yards
2025 New York sat 19th in dropback EPA/play afforded. Nacua commanded 9 targets in Week 1.
Seahawks WR Jaxon Smith-Njigba vs. Cardinals – 81.5 Rec Yards
Arizona slotted 28th in explosive-pass rate allowed in 2025, while JSN enters as the league’s clear #1 receiver after leading the league in receiving yards last season.
Saints WR Chris Olave vs. Ravens – 71.5 Rec Yards
Baltimore allowed the fifth-most explosive pass plays in 2025, while Olave just erupted for 182 yards and 4 20+ yard catches against Detroit.
Cowboys WR CeeDee Lamb vs. Commanders – 75.5 Rec Yards
Washington's defense was fourth-worst at preventing explosive passes a year ago; while Lamb had 8 targets in Week 1 and now plays in Week 2's highest-total game.
49ers WR Mike Evans vs. Dolphins – 48.5 Rec Yards
Miami ranked 27th in dropback EPA allowed in 2025 and struggled to prevent explosive completions. It was encouraging to see Evans receive 7 targets in his team debut last week.
Make NFL Week 2 WR/TE picks on PrizePicks now!
NFL Week 2 Cheat Sheet: TD Scorers
Ravens RB Derrick Henry vs. Saints – 0.5 Player TDs (Goblin)
New Orleans allowed 24 rushing TDs in 2025, tied for the most in the NFL, while Henry already scored three times on 24 carries in Week 1.
Falcons RB Bijan Robinson vs. Panthers – 0.5 Player TDs (Goblin)
Carolina tied with the Saints with the aforementioned 24. Robinson got 29 touches last week and may have plenty of scoring opportunities against a Panthers defense that allowed 59 points in Week 1.
Bengals RB Chase Brown vs. Texans – 0.5 Player TDs (Demon)
Houston allowed 22 rushing TDs in 2025, while Brown received all three of Cincinnati's carries inside the 5-yard line in Week 1.
Make NFL Week 2 TD scorer picks on PrizePicks now!
Make NFL Week 2 Predictions on PrizePicks
Week 2 brings us many more opportunities to earn real money on NFL predictions. Use this NFL Cheat Sheet and predictions to sharpen your takes and build out your winning picks for the Week 2 slate.
You can make your NFL picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct.
With Team Picks, make predictions on winners, spreads, and over/unders, now available in 36 states.
Keep it dialed in on the Playbook for more NFL picks, predictions, and news all season long.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state.Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results.Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
