Minnesota vs. Washington Prediction, Spread, CFB Pick – Saturday, September 26

In the final college football game of Week 4, the Minnesota Golden Gophers travel to the West Coast to take on the Washington Huskies in a Big Ten showdown at 11 p.m. ET on FOX. 

Washington is a 10.5-point favorite on the spread at Husky Stadium, while Minnesota has a 3.84x payout to win outright as the dog, according to PrizePicks.

Below, we’ll break down the Minnesota vs. Washington prediction, spread, and over/under via PrizePicks, including where each team may have an edge.

Make your Minnesota vs. Washington prediction on PrizePicks now! 

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Minnesota vs. Washington Spread, Over/Under, Favorite for Late Night CFB

Washington is a 10.5-point favorite vs. Minnesota in Seattle in this late-night Big Ten showdown, with the over/under set at 46.5 points on PrizePicks. The true spread is closer to 10 points, as there is some juice on the Minnesota +10.5 side. 

Minnesota is 2-1 against the spread this year, while Washington is 0-3. 

Here are the full payouts for Minnesota vs. Washington from PrizePicks, including to win, cover the spread, and the over/under.

Make your Minnesota vs. Washington prediction against the spread on PrizePicks!

PrizePicks data is live at the time of writing and is subject to change.

Minnesota vs. Washington Prediction, Pick Against the Spread – Saturday, September 26

Minnesota hasn’t traveled well under coach P.J. Fleck; the Golden Gophers are 4-11 in true road games since 2023, and they lost all five road games in 2025. Not exactly ideal for a team that has to travel across two time zones and now has to go into a tough environment — a blackout at Husky Stadium in their Big Ten opener.

The Huskies have been elite at home since Jedd Fisch took over the program, sitting at 14-2 since 2024, including a 3-0 start this season. Washington’s only home losses over the last two seasons came to #2 Ohio State and #5 Oregon in 2025.

Minnesota is not the team that’s going to pick up yards in chunks; they rely on strong decision-making, few mistakes, and a reliable offensive line led by LG Greg Johnson and returning LT Nathan Roy.

Running behind that line, the Golden Gophers will get starting RB Darius Taylor back this week after he missed Week 3 with a lower-body injury. He’ll split carries with TJ Thomas, who leads the team with 173 yards thus far.

After Taylor went down, Minnesota threw the ball 34 consecutive times at one point vs. Mississippi State — it didn’t help that the Gophers trailed from the jump. But it’s hard to imagine that will be their approach going forward, especially on the road with Taylor back.

Minnesota QB Drake Lindsey completed 31 of 38 passes for 279 yards vs. Mississippi State in Week 2, and hasn’t thrown an interception in eight straight starts, dating back to last season.

Meanwhile, Washington is still looking to get their run game going, currently down to its preseason fourth- and fifth-string running backs and ranked #73 in rush success rate (43.9%), without a single game vs. a Power Five opponent. That will put all the pressure on QB Demond Williams to take advantage of a Minnesota defense that has looked vulnerable.

Williams is a difficult matchup for any defense to keep in the pocket; he finished with 611 yards rushing in 2025 and already has 150 in three games this year. The Huskies may look to use his legs more with the RB room depleted by injuries.

Minnesota’s run defense looked incredibly vulnerable vs. Mississippi State, giving up 18-113-2 to RB Fluff Bothwell, and another 86 yards to breakout sophomore QB Kamario Taylor. The Golden Gophers rank 103rd out of 138 teams in expected points added (EPA) allowed per rush this year, per Game on Paper.

With WR Dezmen Roebuck coming out of the slot, Washington also has receiving talent that could be problematic for a Gophers’ defense that last year gave up 7.11 yards per dropback.

Washington already has a +6 turnover margin this year through three games, which could create additional opportunities for the Huskies to score points on short fields. Although they’ve had an easy schedule to start, the Huskies’ defense ranks 10th vs. the pass and 3rd vs. the rush in EPA/play — impressive regardless of the schedule. 

If Williams can find some explosives early and the defense continues to limit the run to force Lindsey into passing situations, the Gophers may find themselves in a hole they can’t dig out of. 

Make college football picks on PrizePicks — including winners, players, and totals!

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Make Your Minnesota vs. Washington College Football Prediction on PrizePicks

To close out the Week 4 college football schedule at 11 p.m. ET tonight, Minnesota and Washington open up their Big Ten seasons in Seattle in a clash of styles. 

Minnesota will look to move the ball slow and steady, while Washington will look for explosive opportunities, with Washington QB Demond Williams leading the charge, looking to cover the 10.5-point spread at home.

Don’t wait until kickoff in this late-night CFB game — make your Minnesota vs. Washington picks on PrizePicks. Just pick your players, predict More or Less on their stats, and cash in on your predictions if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders and combine them with players — now available in 36 states!

Keep it here with the Playbook for continued college football picks, predictions, futures, and more as we jump into the 2026 season.