Mercury vs. Sparks Prediction, Spread, WNBA Picks – Wednesday, July 22

The Phoenix Mercury vs. Los Angeles Sparks game is set to tip off at 3 p.m. ET on Wednesday, July 22, televised on WNBA League Pass. According to PrizePicks Team Picks, the Sparks enter as 1.5-point favorites on the spread and return a 1.69x payout if they win.

The Sparks (10-15) return home from an 0-4 road trip, but Los Angeles managed to cover as an underdog in three losses. The Mercury (9-18) snapped a five-game slide in Sunday’s 72-63 home victory over Connecticut, grabbing a split of their two-game home set with the Sun.

Below, we'll break down our Mercury vs. Sparks prediction and picks for Wednesday’s WNBA game, including the spread, over/under, and key player picks for PrizePicks.

Make your Mercury vs. Sparks prediction on PrizePicks now.

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Mercury vs. Sparks Prediction, Spread, Over/Under – Wednesday, July 22

Both Phoenix and Los Angeles sit outside the playoff race approaching this weekend’s All-Star break. The Mercury reached the WNBA Finals last season but own the third-worst record in the league more than halfway through the 2026 campaign.

The Sparks have struggled on the road recently but have won three of their last four at home. Los Angeles topped the 100-point mark in victories over Indiana and Chicago while being limited to 87 or fewer points in each of the past three losses.

In each of the first two matchups this season, the Sparks went into Phoenix and captured a win. Los Angeles knocked off Phoenix, 97-88, as 2.5-point underdogs on May 21 and hit the over on 178.5 points.

The Sparks then outlasted the Mercury in overtime, 111-102, on June 13, highlighted by G Kelsey Plum’s 43 points. It marked L.A.’s third straight win over Phoenix after dropping the previous seven meetings since 2024.

Mercury vs. Sparks Spread, Over/Under – Wednesday, July 22

The Sparks enter Wednesday’s game as 1.5-point home favorites against the Mercury, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Mercury vs. Sparks game on PrizePicks.

• Spread: Los Angeles Sparks -1.5 (1.78x payout)
• Over/Under: 177.5 (1.78x payout on Over)
• Game Winner Payout: Mercury 2.08x | Sparks 1.69x

Make your Mercury vs. Sparks prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Mercury vs. Sparks Injury Report for Wednesday, July 22

Let’s dive into the full Mercury vs. Sparks injury report for Wednesday, July 22, via WNBA.com.

Phoenix Mercury Injury Report

• None

Los Angeles Sparks Injury Report

• G Kelsey Plum (leg) - OUT
• G Kiana Williams (hand) - Questionable

Mercury vs. Sparks Prediction on Winner – 7/22/26

Here are the key game stats and trends behind our Mercury vs. Sparks prediction on the winner for Wednesday, July 22.

• The Sparks are 5-1 against the spread (ATS) in the last six games but were favored once in this span.
• Phoenix is 2-4 ATS in the past six outings, capped off by its 9-point win over Connecticut on Sunday.
• The Mercury are tied with the Dream for the worst defensive 3-point field goal percentage in the league (37.2%).
• However, the Sparks rank 13th in the league in home 3-point shooting at 30.9%.
• In the last two games, Los Angeles struggled from deep, connecting on 12 of 47 attempts (25.5%).
• According to WNBA.com, the Sparks posted net ratings of +11.1 and +11.5 in their two wins over the Mercury.
• The top three net ratings for L.A. all came in home victories, finishing at +13 or higher.
• Phoenix produced a defensive turnover rate of 26.9% against Connecticut. The Mercury are 0-6 this season after putting up a defensive TO rate of 20% or higher.

Lock in your Mercury vs. Sparks prediction on PrizePicks before today's WNBA game.

Mercury vs. Sparks Picks, Player Stats for PrizePicks: 7/22/26

Here are the top Mercury vs. Sparks picks to target on PrizePicks for Wednesday, July 22. Today’s WNBA picks for PrizePicks include Alyssa Thomas and Nneka Ogwumike.

Mercury F Alyssa Thomas vs. Sparks: 30 Pts + Rebs + Asts

• Thomas has topped this PRA projection in six of the last nine games.
• In the first matchup with L.A., Thomas closed with 23 points, 7 rebounds, and 7 assists. She finished with 10 points, 7 boards, and 12 dimes in the OT loss to the Sparks.
• The 13-year veteran scored 7 points in Sunday’s win over Connecticut. Thomas is averaging 15.0 PPG in seven games after posting single-digit outputs.  
• Thomas put up a PRA of at least 35 eight times in 2026, including six on the road.

Add Alyssa Thomas to your PrizePicks Lineup now.

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Sparks F Nneka Ogwumike vs. Mercury: 17 Points

• Ogwumike scored 17+ points in six straight games, including three performances of at least 23 points.
• Her consistency is unmatched in this respect, she is averaging exactly 17.3 PPG both at home and on the road.
• Ogwumike's usage has jumped to 24.3% in July, which also ties into Plum’s injury. Over the last nine games, Ogwumike is averaging 19.8 PPG.

Add Nneka Ogwumike to your PrizePicks Lineup now.

Make Mercury vs. Sparks Picks on PrizePicks

It’s the final game before the All-Star break for the Mercury and Sparks. Which team will grab a matinee victory in hopes of getting momentum going for a playoff berth down the stretch?

Don’t wait until tip-off — make your Mercury vs. Sparks picks on PrizePicks now and earn real money if you’re right.

Pick WNBA players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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