Lynx vs. Mystics Prediction, Spread, WNBA Picks – Friday, August 21

The Minnesota Lynx vs. Washington Mystics game is set to tip off at 7:30 p.m. ET on Friday, August 21, televised on ION. According to PrizePicks Team Picks, the Lynx enter as 1.5-point favorites on the spread, with a 1.66x payout if they win.

The Lynx (30-7) seek their sixth consecutive victory after beating the Valkyries for the ninth straight time on Wednesday, 77-66. Minnesota looks to sweep its four-game road trip while seeking to improve on a 16-2 mark away from Target Center.

The Mystics (20-16) won their eighth time over the last 10 games in Wednesday’s 93-82 home triumph over Toronto. Since losing to Portland on July 16, Washington has run off eight consecutive home wins. 

Below, we'll break down our Lynx vs. Mystics prediction and picks for Friday's WNBA game, including the spread, over/under, and key player picks for PrizePicks.

Make your Lynx vs. Mystics picks on PrizePicks now!

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Lynx vs. Mystics Prediction, Spread, Over/Under – Friday, August 21

Minnesota continues to pull away from the pack, becoming the first team to reach 30 wins in Wednesday's 77-66 win. The Lynx led from start to finish against the Valkyries in a battle of the top two squads, allowing the second-fewest points (66) this season.

The duo of G Olivia Miles and F Kayla McBride each scored 20 points for Minnesota, while F Napheesa Collier put up 18 points. The Lynx have now won 15 of their last 16 games.

Collier will sit out tonight to rest for the first time since July 22, when she returned from her ankle injury in last season’s playoffs.

The Mystics have held their own in two matchups with the Lynx this season. Washington shocked Minnesota as a 13.5-point road underdog, 84-79, on June 21. 

Three days later in D.C., the Lynx grabbed revenge in a 78-76 triumph, but the Mystics covered again as 8.5-point dogs. Minnesota outscored Washington 28-18 in the fourth quarter, as the Lynx have not lost to the same team twice in 2026.

Lynx vs. Mystics Spread, Over/Under – Friday, August 21

The Lynx enter Friday’s game as 1.5-point road favorites against the Mystics, returning a 1.66x payout if they win outright, per PrizePicks Team Picks.

Here are the full payouts for the Lynx vs. Mystics game on PrizePicks.

Make your Lynx vs. Mystics prediction on the spread or over/under on PrizePicks Team Picks—available in 36 states!

Team Picks data is live at the time of writing and is subject to change.

Lynx vs. Mystics Injury Report for Friday, August 21

Let’s dive into the full Lynx vs. Mystics injury report for Friday, August 21, via WNBA.com.

Minnesota Lynx Injury Report

• F Napheesa Collier (rest) - OUT
• G Olivia Miles (ankle) - Probable

Washington Mystics Injury Report

• None

Lynx vs. Mystics Prediction on Winner – 8/21/26

Here are the key game stats and trends behind our Lynx vs. Mystics prediction on the winner for Friday, August 21, in the WNBA game on ION.

• The Mystics are 4-1 against the spread (ATS) in their last five matchups with the Lynx.
• According to WNBA.com, Washington leads the league in percentage of points from free throws (22.2%). Minnesota is last in this category, with 15.4% of its points at the line.
• The Mystics are 9-1 ATS as a home underdog, including six outright victories.
• The Lynx have covered 10 of 14 times as a favorite of 5.5 points or less.
• During this eight-game home winning streak, the Mystics have scored 22+ points on free throws on five occasions.
• Washington leads the league in defensive effective field goal percentage (eFG%) at 48.8% and ranks fourth at home (48.7%).
• The Lynx posted a season-low 43.7% eFG% in the 2-point win at Washington.

Lock in your Lynx vs. Mystics prediction on PrizePicks before tonight’s WNBA game.

Lynx vs. Mystics Picks, Player Stats for PrizePicks – 8/21/26

Here are the top Lynx vs. Mystics picks to target on PrizePicks for Friday, August 21. Today’s WNBA picks for PrizePicks include Olivia Miles and Kiki Iriafen.

Lynx G Olivia Miles vs. Mystics: 18 Points

• Miles has scored at least 20 points in six of the last seven games. She posted 20 points on 8-of-10 shooting in Wednesday’s win at Golden State. 
• According to PropsMadness, the former TCU standout put up more than 20 points in five of seven games against teams with a defensive rating of fourth or higher (Mystics are second).
• In two meetings with the Mystics, Miles has compiled 22 and 21 points, but is shooting only 2 of 10 from deep.
• In the last 12 road games, the second pick of this year’s draft scored 20+ points seven times and is averaging 20.0 PPG in this stretch.

Add Olivia Miles to your PrizePicks Lineup now.

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Mystics F Kiki Iriafen vs. Lynx: 23.5 Pts + Rebs

• Iriafen compiled at least 25 combined points and rebounds in 12 of the last 20 games.
• Her best performance in the last 10 games came in Wednesday’s win over Toronto, posting 21 points and 13 boards.
• The former USC star has pulled down at least 10 rebounds in 13 of the past 20 games. Minnesota owns the fourth-lowest defensive rebounding rate (67.5%) in the league.
• In the first two meetings with the Lynx, Iriafen closed with exactly 24 combined points and rebounds. Her offensive ratings in those games were 96.3 and 81.3, both sitting among her 11 worst-rated performances.

Add Kiki Iriafen to your PrizePicks Lineup now.

Make Your Lynx vs. Mystics Prediction on PrizePicks

Washington looks for its ninth consecutive home win to knock off the best team in the league. Will the Mystics stay hot at home, or will the Lynx continue to roll on the road?

Don’t wait until tip-off—make your Lynx vs. Mystics picks on PrizePicks now and earn real money if you’re right.

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