Lions vs. Colts Prediction, NFL Preseason Picks – Saturday, August 29

We are entering the final week of the preseason, and with it come the final roster cuts before teams set their 53-man rosters on Sunday. This means some of these players have one last chance to impress to make the team.

That will be the case in the battle between the Detroit Lions and the Indianapolis Colts, who clash on Saturday, August 29, in Indianapolis. For this 1:00 p.m. ET matchup on the NFL Network, the Colts are favored with a 1.53x payout for an outright win, per PrizePicks Team Picks. 

Below, we'll break down our Lions vs. Colts prediction and picks for Saturday’s NFL preseason game, including the spread, over/under, and key player picks for PrizePicks.

Make your Lions vs. Colts prediction and picks on PrizePicks now!

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Lions vs. Colts Prediction, Spread, Over/Under for NFL Preseason – Saturday, August 29

The Colts enter Saturday’s game as 3.5-point home favorites against the Lions, returning a 1.53x payout on PrizePicks Team Picks if they win outright.

Here are the full payouts for the Lions vs. Colts NFL preseason game on PrizePicks.

Make your Lions vs. Colts prediction on the spread or over/under on PrizePicks Team Picks—available in 36 states!

Payouts show potential returns on correct Team Picks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

Lions vs. Colts Prediction on Spread for NFL Preseason – 8/29/26

Here are the key game stats and trends behind our Lions vs. Colts prediction on the spread for the Saturday, August 29 game. 

• Colts head coach Shane Steichen said most of the first team will play, except QB Daniel Jones, RB Jonathan Taylor, TE Tyler Warren, and WR Alec Pierce. 
• Among the starters for the Colts is newly signed veteran WR Keenan Allen, who is making his debut with the team.
• The Lions will likely not play their starters in this matchup, as head coach Dan Campbell typically opts to rest key players.
• The Colts’ offense has struggled in the preseason, scoring 19 points, the second-fewest in the AFC.
• There is still a wide-open battle for the Colts’ backup quarterback spot between Anthony Richardson Sr. and Riley Leonard, perhaps adding to Indy's level of play as this game progresses.

Lock in your Lions vs. Colts prediction on PrizePicks before today's NFL preseason game.

Lions vs. Colts Picks, Player Stats for NFL Preseason on PrizePicks: 8/29/26

Here are the top Lions vs. Colts picks to target on Saturday, August 29. Today’s NFL preseason picks for PrizePicks include QB Anthony Richardson Sr. and TE Jackson Meeks.

Colts QB Anthony Richardson Sr. vs. Lions: 39.5 Pass Yards

• Richardson is expected to play the entire first half of this matchup, providing plenty of snaps to flirt with this projection.
• This could be a showcase for Richardson’s next team, as there are rumors that several teams have inquired about a potential trade.
• Richardson has outplayed Riley Leonard, proven by 169 passing yards and a 60.9% completion rate in the preseason. Meanwhile, Leonard sports 151 passing yards and a 48.6% completion rate through two contests.
• The Lions have been an average pass defense in the preseason, allowing 183.5 passing yards per game, which ranks 16th.
• With the Lions not expecting to play their first unit, Richardson will have a chance to play against the backups.

Add Anthony Richardson Sr. to your PrizePicks Lineup now.

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Lions TE Jackson Meeks vs. Colts: 15.5 Receiving Yards

• Jackson Meeks is a former wide receiver whom the Lions cut last year. He gained 25 pounds and converted to tight end.
• This change has generated results, as he leads the Lions with 33 receiving yards in the preseason.
• Meeks is competing against Thomas Gordon and Zach Horton for the TE4 job, according to the Lions' depth chart.
• The Colts’ defense has been torched through the air in the preseason, allowing 502 total passing yards (22nd).

Add Jackson Meeks to your PrizePicks Lineup now.

Make Lions vs. Colts Picks for NFL Preseason on PrizePicks

The Lions and Colts will deploy different strategies in this Week 3 preseason matchup. The Colts are expected to feature some starters, while the Lions will likely keep their first unit in street clothes.

Don’t wait until kickoff for more preseason football—make your Lions vs. Colts picks on PrizePicks now and earn real money if you’re right.

Pick NFL players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on preseason NFL game winners, spreads, over/unders, and futures, now available in 36 states.

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