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Knicks vs. 76ers Prediction, Spread: All-Stars Brunson, Maxey Tangle

76ers G Tyrese Maxey guards Knicks G Jalen Brunson.
AP Photo/Matt Slocum

Division rivals will do battle for the fourth time this season when the New York Knicks (34-19) roll into the Xfinity Mobile Arena to take on the Philadelphia 76ers (30-23). The 76ers hold a 2-1 season series advantage, which the Knicks will look to even up, despite being on the tail end of a back-to-back.

Knicks vs. 76ers tips off at 7:30 p.m. ET on Wednesday from Philadelphia., live on ESPN.

Below, we’ll break down our Knicks vs. 76ers prediction and spread for PrizePicks. Use PrizePicks NBA to make picks on player projections and win real money if you’re right.

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Knicks vs. 76ers Prediction, Spread

Despite last night’s overtime loss at the hands of the Indiana Pacers, the Knicks have been rolling. They are 8-2 over their last 10 games and have the NBA’'s fourth-best net rating over that same timespan (+10.8).

They currently sit third in the Eastern Conference, but the gap between second and sixth is just four games, so every game they play from here on out will have serious playoff implications.

It’s difficult to find a stat this season where the Philadelphia 76ers aren’t in the middle of the pack. They have the 13th-best record in the league while ranking 12th in offensive rating (115.4) and 15th in defensive rating (114.2).

The story of their season has been the re-emergence of C Joel Embiid. Embiid has completely turned back the clock, and instead of fading as the season progresses, he is only improving. He has increased his scoring average every month this season, from 17.3 points per game (PPG) in October to 30.7 PPG so far in February. His continued good health will be paramount if the 76ers are to make a run this postseason.

 “Yes” for the Philadelphia 76ers to hoist this year’s Larry O’Brien trophy is currently returning a 22.22x payout on PrizePicks Team Picks


Knicks vs. 76ers Over/Under, Spread

The Knicks enter Wednesday’s game as 1.5-point road favorites, returning a 1.81x payout on PrizePicks Team Picks if they win outright.

The 76ers are short home underdogs with a 1.88x payout if they win, via PrizePicks Team Picks.

  • Spread: New York Knicks -1.5 (1.69x payout)
  • Over/Under: 223.5 (1.69x payout on over)
  • Game Winner Payout: Knicks 1.81x | 76ers 1.88x

Team Picks payouts are live as of publishing and are subject to change.


Knicks vs. 76ers Injury Report

Let’s dive into the full Knicks vs. 76ers injury report for Wednesday, via NBA.com.

Knicks Injury Report

  • Not available as of publication

76ers Injury Report

  • PF Dominick Barlow (Illness): Questionable
  • SG Quentin Grimes (Illness): Questionable
  • C Joel Embiid (Knee): Questionable
  • SF Paul George (Suspension): OUT

Knicks vs. 76ers Prediction on Over/Under

Here are some stats to help you make your Knicks vs. 76ers prediction on the over/under today.

  • Both these teams rank in the bottom-ten in pace this season, according to NBA.com. The 76ers rank 20th, while the Knicks rank 23rd.
  • The under is 14-11-0 (56%) against the spread in Knicks road games this season.
  • Over the last 10 games, the Knicks have the best defensive rating in the NBA (105.8).
  • In the three games these teams have played so far this season, the total has gone under 223.5 points in two.

Knicks vs. 76ers NBA Picks, Stats for PrizePicks Today

Here are two of the top Knicks vs. 76ers picks to consider for PrizePicks today. Player projections via the PrizePicks real-money NBA game.

Knicks PG Jalen Brunson vs. 76ers Projection: 35.5 Pts+Reb+Asts

  • Brunson is averaging 36.8 points, rebounds, and assists (PRA) per game this season.
  • JB has had more than this number in all three of his matchups vs. the 76ers this year.
  • The 76ers are giving up 27.5 assists per game this season, the sixth-most in the NBA.
  • Jalen Brunson will primarily be guarded by SG VJ Edgecome and PG Tyrese Maxey; those two players have defensive ratings of 113.5 and 113.3, respectively. Those are the fourth- and fifth-worst defensive ratings among eligible 76ers. 

76ers PG Tyrese Maxey vs. Knicks Projection: 36.5 Pts+Reb+Asts

  • The Kentucky product is averaging 39.8 PRA this season, well above the projected number of 36.5.
  • The Knicks' defense is allowing 38.8 3-point attempts this season, tied for fifth-most in the league. The 76ers star PG is shooting 8.8 3-point attempts per game.
  • Maxey will be guarded primarily by PG Jalen Brunson, who has the worst defensive rating on the Knicks at 115.3.

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Make Knicks vs. 76ers NBA Picks on PrizePicks

The Knicks will look to continue their quality play and even the season series vs the Philadelphia 76ers tonight. Knicks vs. 76ers picks aren’t the only way hoops fans can get in on the daily NBA action.

You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states. 

Stick around with the Playbook for continued NBA predictions, picks, and news.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Adi Narang is a professional sports bettor and New York University graduate in Sports Management. A lifelong Denver sports fan, he’s spent over a decade applying data-driven analysis to trends, pricing, and game-level predictions. He’s always up for a sports conversation — from a Nikola Jokić GOAT debate to Korean Baseball batting orders.

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