The 2026 NFL season rolls into Week 2 with a fascinating AFC showdown as the Jacksonville Jaguars travel to Empower Field at Mile High to take on the Denver Broncos. Sunday, September 20's matchup kicks off at 4:05 p.m. ET on CBS, with Denver a 2.5-point home favorite, per PrizePicks.
The two teams enter Sunday's matchup coming off drastically different Week 1 performances. Jacksonville dominated the Cleveland Browns 34-10 behind 4 passing TDs from QB Trevor Lawrence, while Denver struggled in a 31-10 loss to the Kansas City Chiefs.
Below, we'll break down our Jaguars vs. Broncos prediction and picks for Sunday's NFL Week 2 game, including the spread for PrizePicks.
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Jaguars vs. Broncos Prediction, Spread, Over/Under – Sunday, September 20
Jacksonville enters Week 2 with plenty of momentum after putting together one of the most impressive offensive performances of the opening weekend.
Jaguars QB Trevor Lawrence completed 18 of 23 passes for 245 yards and 4 TDs, finishing with a 150.6 passer rating and no turnovers. The Jaguars also moved the ball efficiently on the ground, helping HC Liam Coen's offense convert 50.0% of its third downs and score on both of its red-zone trips.
This is a much more difficult matchup on paper, but Jacksonville has already shown it can compete with Denver. The Jaguars defeated the Broncos 34-20 in Denver last season, with Lawrence throwing for 279 yards and 3 TDs.
Denver, meanwhile, couldn't have asked for a better opportunity to regroup after its Week 1 disaster. The Broncos managed just 176 total yards against Kansas City and converted only 2 of 12 third downs. QB Bo Nix finished with 131 passing yards, while Denver's offense turned the ball over twice and was unable to generate any consistent rhythm.
The defense was also uncharacteristically sloppy. Denver missed 28 tackles against Kansas City, allowing 247 yards after contact — the most by any defense in a game since at least 2018.
The Broncos still have the talent and home-field advantage to turn things around, but Sunday's matchup will tell us whether Week 1 was simply an ugly opener or a sign of more profound problems.
Jaguars vs. Broncos Spread, Over/Under – Sunday, September 20
Denver enters Sunday's game as a 2.5-point home favorite against Jacksonville via PrizePicks.
Here are the full payouts for Jaguars vs. Broncos on PrizePicks.
Make your Jaguars vs. Broncos prediction on the spread on PrizePicks.
PrizePicks data is live at the time of writing and is subject to change.
Jaguars vs. Broncos Prediction on Spread – 9/20/26
Here are the key stats and predictions behind our Jaguars vs. Broncos prediction on the spread for PrizePicks.
- HC Sean Payton is 61-37-1 (62%) against the spread (ATS) after a defeat, the second-highest mark for a coach in NFL history.
- Many will look at the Jags being 9-0 straight up over their last nine games but ignore that five of the QBs they faced were Riley Leonard, Brady Cook, Phillip Rivers, Brandon Allen, and Deshaun Watson.
- Denver led the NFL in sacks by 11 last season, but last week's result of missing tackles at a 30% clip draws concerns. A drastic rebound could be ahead for one of the league's best defenses.
- Major positive regression may come for a Broncos offense that averaged over 340.0 yards per game last season and added an alpha WR in Jaylen Waddle. New OC Davis Webb had a rough debut for Denver, so if it starts slow again, HC Sean Payton could take over the plays.
- The Jaguars are traveling to Denver and playing at altitude against a Broncos team coming off a humiliating divisional loss. Sean Payton has emphasized the importance of the home opener, while Denver's defense has additional motivation after Jacksonville scored 34 points against it in last year's meeting.
Lock in your Jaguars vs. Broncos prediction on PrizePicks before Sunday's NFL game.
Jaguars vs. Broncos Picks, Player Stats for PrizePicks – 9/20/26
Here are the top Jaguars vs. Broncos picks to target on PrizePicks for Sunday afternoon, including Trevor Lawrence and Bo Nix.
Jaguars QB Trevor Lawrence vs. Broncos: 220.5 Pass Yards
- The Trevor Lawrence emergence is here. Lawrence completed 18 of 23 passes for 245 yards in Week 1 and should be playing in a more neutral game script that encourages more pass attempts.
- He also shredded this exact Broncos defense last season, throwing for 279 yards in Jacksonville's 34-20 victory in Denver.
- Denver's defense remains extremely talented, but the Broncos just allowed 247 yards after contact against Kansas City. Jacksonville has a bevy of explosive run-after-catch receivers who can punish that inefficiency if it continues.
- HC Liam Coen runs a slightly more pass-friendly scheme than most head coaches, opting to pass on 55.0% of his plays.
Add Trevor Lawrence to your PrizePicks lineup now.
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Broncos RB J.K. Dobbins vs. Jaguars: 57.5 Rush Yards
- Dobbins could be in line for a significant workload with R.J. Harvey questionable to play because of a hamstring injury.
- Denver's offense desperately needs to establish the run after rushing for 61 yards on just 15 attempts last week.
- Despite the blowout, the Browns still averaged 4.0 YPC against the Jags' run defense.
- Last year, the Jags defense operated as a run funnel. The unit ranked second in EPA/pass (-0.19) but 12th in EPA/run (-0.07).
- Dobbins will be running behind what many, including Warren Sharp, consider the best offensive line in football.
Add J.K. Dobbins to your PrizePicks lineup now.
Make Jaguars vs. Broncos Picks on PrizePicks
Sunday's matchup gives us an interesting clash between a Jacksonville team coming off an explosive Week 1 performance and a Denver squad desperate to erase the memory of its Monday night disaster.
The Jaguars have already shown that Trevor Lawrence and Liam Coen's offense can move the football efficiently, while Denver's defense has to prove its Week 1 tackling issues were an anomaly.
On the other side, Denver's offense has nowhere to go but up after managing just 176 total yards in Kansas City. Playing at home should help, but the Broncos need substantially better play from Bo Nix and their offensive line.
Don't wait until kickoff — make your Jaguars vs. Broncos picks on PrizePicks Team Picks. There is a wide variety of player stat projections on the NFL board, so you can make predictions on yards, touchdowns, and more! Just pick your players, predict More or Less on their stats, and cash in on your predictions if you're right.
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