Fiorentina vs. Atalanta Prediction, Picks, XIs for Serie A – 5/22/26

Friday’s Serie A match between Fiorentina and Atalanta is set to kick off at 2:45 p.m. ET. Fiorentina enters the Serie A match as slight underdogs on their home pitch, returning a 2.56x payout on PrizePicks with a win. 

The two Italian sides are essentially locked into their positions in the Serie A table heading into the final matchweek. Atalanta has already secured a spot in UEFA’s Conference League next season, while Fiorentina is simply playing out the season with no danger of relegation but no ability to secure a European spot, either.

Below, we'll break down our Fiorentina vs. Atalanta prediction and picks for Friday's Serie A match, including winner payouts, total goals, and top Serie A picks for PrizePicks today.

Make your Fiorentina vs. Atalanta prediction on PrizePicks for Friday’s Serie A match now.

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Fiorentina vs. Atalanta Prediction, Picks for Serie A Match – Friday, May 22

Atalanta travels to Florence to close out the Serie A season against Fiorentina. Raffaele Palladino’s squad defeated La Viola 2-0 when they first met back in November. 

Despite being just three points above Bologna, Atalanta already secured seventh place and a spot in Europe next year due to a tiebreaker. On the other hand, Fiorentina will be playing for pride alone, as they could be headed for their worst finish in the Italian top flight since 2018-19.

Paolo Vanoli’s squad is sitting on just 9 wins along with a league-leading 14 draws. La Viola has drawn three of its last five Serie A matches before picking up a big win over Juventus, a team fighting for a Champions League spot for next season.

Just last month, Fiorentina was still competing in the UEFA Conference League quarterfinals, where they eventually lost 4-2 on aggregate score. Vanoli helped dig La Viola out of a significant hole it found itself in to start the season. 

Fiorentina opened the Serie A season without a win in its first 10 matches before sacking the previous manager, Stefano Pioli. If Fiorentina can defeat Atalanta on Friday, Vanoli will have salvaged what looked to be a relegation-worthy season into double-digit wins and a deep run in a European tournament. 

The Italian manager will be without the services of his top goalscorer this season, Moise Kean, who is set to miss his sixth straight Serie A match with a muscle injury.

For Atalanta, Palladino is expected to have his full cast, aside from defenders Lorenzo Bernasconi and Odilon Kossounou. With little left to play for in terms of the Bergamo club's final standings, we may see Palladino rotate the squad, giving some younger players a chance to feature.

Fiorentina vs. Atalanta Spread, Total Goals, Payouts – Friday, May 22

Fiorentina enters Friday’s game as home underdogs against Atalanta, returning a 2.56x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Fiorentina vs. Atalanta game on PrizePicks.

• Winner Payout: Fiorentina – 2.56x | Tie – 3.22x | Atalanta – 2.43x
• Spread: Atalanta -1.5 (4.76x Payout)
• Total Goals: 2.5 (Over – 1.66x)
• Both Teams to Score: Yes 1.58x | No 2.27x

Play the Fiorentina vs. Atalanta spread or total goals on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Fiorentina vs. Atalanta Prediction on Total Goals – 5/22/26

Here are some stats to know to help you make your Fiorentina vs. Atalanta prediction on the total goals scored for Friday, May 22. Check out more of our soccer picks and predictions on Playbook.

Lock in your Fiorentina vs. Atalanta prediction on PrizePicks now.

• Atalanta ranks among the top six teams for fewest goals conceded, with 0.9 goals per game. That number is slightly higher at 1.4 over their last five matches.
• Palladino’s squad has amassed 57.96 xG, ranking in the top five in Serie A. Atalanta has underperformed its xG by 7.96.
• Despite scoring just 40 goals, Fiorentina also ranks among the top in Serie A in xG with 52.54 total. 
• Fiorentina ranks in the top three in Serie A with 3.3 saves per game. La Viola concedes 1.3 goals per game for the season but has kept a clean sheet in three of its last four matches.
• Atalanta’s attack has been high-powered, ranking third in total shots per game with 14.6. Fiorentina ranks ninth in this category at 12.9.

Fiorentina vs. Atalanta Projected Lineups for Friday, May 22

Take a look at the Fiorentina vs. Atalanta projected lineups for today’s Serie A match. Lineups are not official and should be confirmed before match start.

Fiorentina Lineup vs. Atalanta: Projected 4-3-3

• Goalkeeper: David de Gea
• Defense: Dodo, Marin Pongracic, Daniele Rugani, Robin Gosens
• Midfield: Rolando Mandragora, Nicolo Fagioli, Cher Ndour
• Forwards: Manor Solomon, Roberto Piccoli, Albert Gudmundsson

Atalanta Lineup vs. Fiorentina: Projected 3-4-2-1

• Goalkeeper: Marco Carnesecchi
• Defense: Sead Kolasinac, Isak Hien, Giorgio Scalvini
• Midfield: Nicolas Zalewski, Ederson, Marten de Roon, Davide Zappacosta
• Forwards: Giacomo Raspadori, Nikola Krstovic, Charles De Ketelaere 

Fiorentina vs. Atalanta Picks, Player Stats for PrizePicks: 5/22/26

Here are Fiorentina vs. Atalanta picks to target for Serie A on Friday, May 22. Today’s Serie A picks include David De Gea and Ederson.

Fiorentina GK David de Gea vs. Atalanta

David de Gea Projections via PrizePicks: 3 Goalie Saves, 31.5 Passes Attempted, 10.5 Goalie Fantasy Score 

• David de Gea’s 3.3 saves per game rank third in Serie A. The Spanish keeper is coming off a season-high 9 saves against Juventus on Sunday.
• The veteran keeper is averaging 32.76 passes attempted in his 37 Serie A matches. This number has slightly dropped to 31.4 over his last five.
• de Gea had 7 saves when these teams met earlier this year. Atalanta has scored 5 goals in three matches against the 35-year-old keeper.

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Atalanta MF Ederson vs. Fiorentina

Ederson Projections via PrizePicks: 0.5 Shots (Goblin), 45.5 Passes Attempted, 1.5 Tackles

• Could Ederson be aggressive in what is expected to be his final match for Atalanta? The Brazilian midfielder is averaging 1.2 shots per game.
• Ederson is averaging just over 45 passes attempted in 30 appearances this season. This number has dropped significantly over the last five games, with him moving into a less on-ball role. Ederson is averaging 35 passes attempted over his last four matches.
• The 26-year-old is averaging 2 tackles per game, hitting that mark in each of his last three matches. 

 Add Ederson to your PrizePicks Lineup now!

Make Fiorentina vs. Atalanta Picks on PrizePicks

Fiorentina looks to conclude the Serie A season on a high note after an overall disappointing campaign from La Viola. Atalanta, meanwhile, aims to sweep the series when they travel to Stadio Artemio Franchi on Friday.

Don’t wait until match start — you can make your Fiorentina vs. Atalanta picks for Friday’s Serie A match now on PrizePicks and PrizePicks Team Picks to earn real money. 

Just pick your Serie A players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on match winner, total goals, and both teams to score – now available in 35 states. 

Stay locked in with the Playbook for continued soccer and Serie A predictions, picks, and analysis.