Saturday night football is back in the NFL, and the first of two Week 16 divisional games for the day packs a punch.
An early-evening bout between the Eagles and Commanders (5:00 p.m. ET on FOX) sees QBs Jalen Hurts and Marcus Mariota square off. With Philadelphia chasing a prime playoff seed and Washington looking ahead to the future, two conflicting organizational paths will intersect for a night.
Below, we’ll break down our Eagles vs. Commanders prediction and Saturday picks to consider. Use PrizePicks NFL to monitor player projections and make picks for real rewards if you’re right.
Eagles vs. Commanders Prediction, Spread, Over/Under
Saturday marks the first time these two squads will see each other in a three-week span. Washington leads the all-time series with a 90-86-5 advantage, although Philadelphia has rattled off four wins in the last five meetings.
On the injury front, the Eagles will be without OT Lane Johnson and DT Jalen Carter. For the Commanders, several players beyond QB Jayden Daniels are out, including LT Laremy Tunsil.
Eagles vs. Commanders Over/Under, Spread
The Eagles enter Saturday’s game as 6.5-point road favorites, returning a 1.28x payout on PrizePicks Team Picks if they win outright.
The Commanders are home underdogs with a 3.44x payout if they win, via PrizePicks Team Picks.
- Spread: Philadelphia Eagles -6.5
- Over/Under: 45.5
- Game Winner Payout: Eagles 1.28x | Commanders 3.44x
Team Picks data is live at the time of writing and is subject to change.
Eagles vs. Commanders Prediction on Spread
Here are some stats to know to get you prepared for Eagles vs. Commanders.
- Dating back to 2023, the Eagles are 8-8-1 against the spread in divisional games and 12-5 overall. Washington’s marks are 6-9-1 and 6-10, respectively.
- This year’s Philly squad snapped out of its three-game funk by blowing the Raiders out, 31-0, in Week 15.
- Philadelphia’s defense is turning things up a notch, ranking fifth in points per drive and sixth in overall scoring.
- Since starting the season 3-2, the Commanders are 1-8 and have shut down Daniels for the year.
- An anemic offense (24th in points per drive) and an even worse defense (30th) have Washington consistently behind the proverbial eight ball.
Eagles vs. Commanders Saturday NFL Picks
Here are three Eagles vs. Commanders picks for Saturday’s Week 16 game. Some top same-game PrizePicks projections to consider include QB Jalen Hurts, RB Saquon Barkley, and QB Marcus Mariota.
Eagles QB Jalen Hurts vs. Commanders Projection: 219.5 Pass Yards
- Through 14 games, Hurts averages 209.2 passing yards per game. In his last four contests, however, that number is a healthy 233.5.
- Per SumerSports, among all QBs with 250+ plays, Hurts’ 9.61 average depth of target is second-highest.
- Washington has yielded the fifth-most passing yards (3,638) to the QB position this year.
- According to Jefe’s Handiwork, the Commanders’ 77.2% series conversion rate allowed is the third-worst in the sport.
Eagles RB Saquon Barkley vs. Commanders Projection: 77.5 Rush Yards
- Barkley’s had a rough season, averaging just 67.1 rushing yards per game. Since his 22-yard showing in Week 12, though, he’s up to 85.3 yards a contest.
- 2024’s Offensive Player of the Year nets 99.1 rushing yards per outing against Washington, his seventh-highest total against any opponent. He combined for 414 yards in three games against them last season (one playoff bout).
- With 23 rushes of 10+ yards, Barkley ranks 11th among all qualified ball carriers, via NFL Pro.
- The Commanders rank 26th in EPA/rush allowed at 0.03, per SumerSports.
Commanders QB Marcus Mariota vs. Eagles Projection: 235.5 Pass + Rush Yards
- Across his seven starts this year, Mariota averages 252 combined passing and rushing yards.
- Per NFL Pro, Mariota has used play-action on 25.8% of his shotgun dropbacks, the NFL’s highest figure. The Eagles surrender an NFL-high 10.9 yards per throw on such passes.
- Among all QBs with 250+ plays logged in 2025, Mariota’s 7.32% scramble rate is ninth.
- Philadelphia has allowed the second-most rushing yards to QBs this season with 329.
Make Eagles vs. Commanders Picks on PrizePicks
When Philadelphia and Washington duke it out, there will be plenty of opportunities for Eagles vs. Commanders picks. The NFL Week 16 slate also leaves the door open for several other player projections and much more.
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