Dodgers vs. Astros is set for first pitch at 2:10 p.m. ET on Wednesday, May 6, with the Dodgers returning a 1.42x payout if they win, via PrizePicks.
The Dodgers will send another terrific pitcher to the mound in SP Tyler Glasnow (3-0, 2.56 ERA). Meanwhile, the Astros deploy one of their struggling starters in SP Lance McCullers Jr. (2-2, 6.32 ERA). Los Angeles also enters with a well-rested bullpen after SP Shohei Ohtani logged 7.0 innings Tuesday.
Below, we’ll break down our Dodgers vs. Astros prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
Make your picks for Dodgers vs. Astros on PrizePicks now.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Dodgers vs. Astros Prediction, Winner Payout, Over/Under – Wednesday, May 6
The Dodgers and Astros have split the first two games of this series. The Astros won Tuesday’s game 2-1 but have only scored a total of 5 runs in the series. Even with that little slump, they're tied for the fifth-most runs in baseball.
Los Angeles also has a potent lineup, checking in at fourth in runs scored. The big difference between these teams comes on the pitching side of things.
Per FanGraphs, the Dodgers have a 3.69 xERA and a 1.11 WHIP. Houston has a 4.67 xERA and a 1.62 WHIP.
Dodgers vs. Astros Winner Payout, Over/Under – Wednesday, May 6
The Dodgers enter Wednesday’s game as a road favorite against the Astros, returning a 1.42x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Dodgers vs. Astros game on PrizePicks.
- Spread: Los Angeles Dodgers -1.5 (1.72x payout)
- Over/Under: 8.5 runs (1.75x payout on Over)
- Game Winner Payout: Dodgers 1.42x | Astros 2.63x
Play the Dodgers vs. Astros winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live as of writing and is subject to change.
Dodgers vs. Astros Prediction on Winner – 5/6/26
Here are the key game stats and trends behind our Dodgers vs. Astros prediction on the winner for Wednesday, May 6.
Lock in your Dodgers vs. Astros prediction on PrizePicks before the line moves.
- The Dodgers are 4-2 in games that were started by Glasnow this year.
- L.A. has a +67 run differential, which ranks third in baseball. Meanwhile, the Astros have a -27 run differential, fifth-worst.
- Los Angeles does a good job of keeping hitters inside the ballpark, allowing 0.9 HR/9. Houston cedes considerably more at 1.4 HR/9.
- The Astros giving up a lot of home runs could be problematic for this matchup, a thse Dodgers are tied for the fourth-most home runs in baseball.
- Astros SS/3B Carlos Correa suffered an ankle injury Tuesday that will likely keep him out multiple weeks.
Dodgers vs. Astros Player Picks, Stats for PrizePicks: 5/6/26
Here are top Dodgers vs. Astros picks to target on PrizePicks for Wednesday, May 6. Today's MLB picks for PrizePicks include DH Shohei Ohtani and 1B Freddie Freeman.
Dodgers DH Shohei Ohtani vs. Astros Projection: 1.5 Total Bases
- After going hitless in five straight games, Ohtani wasn't in the lineup Tuesday as he started for the Dodgers in their matchup.
- Prior to his recent mini-slump, the two-way star had back-to-back games with 3 hits each.
- Of Ohtani’s 30 hits, 12 of them have been for extra bases.
- After allowing a 49.7% hard-hit rate last season, McCullers has permitted a 48.1% mark in 2026, per FanGraphs.
- The right-handed hurler has given up at least 1 home run in three of his last four starts.
Add Shohei Ohtani to your PrizePicks Lineup now.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Dodgers 1B Freddie Freeman vs. Astros Projection: 6.5 Hitter Fantasy Score
- Freeman is 8-for-22 with 2 doubles, 3 RBI, and 1 run scored during his current five-game hitting streak.
- The former Atlanta Braves star continues to do a great job of making contact, posting a 14.0% strikeout rate. For his career, that number is 18.8%.
- Freeman has followed up his .380 wOBA and .229 ISO on the road last season with a .434 wOBA and a .212 ISO away from Los Angeles this year.
- McCullers has a 1.40 WHIP. The bullpen behind him has been even worse, recording a 1.65 mark while allowing 31 home runs.
Add Freddie Freeman to your PrizePicks Lineup now.
Make Dodgers vs. Astros Picks on PrizePicks
The Dodgers have a significant starting pitching advantage entering Wednesday, and Ohtani and Freeman could particularly shine. Not only has McCullers performed poorly, but behind him is one of the worst bullpens in the majors. Can Houston shine anyway?
Don’t wait until the first pitch — make your Dodgers vs. Astros picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 MLB season.
