Following MLB Opening Day, Friday is loaded with an eight-game slate. Plenty of primetime action is ahead, including the Arizona Diamondbacks (0-1) vs. the Los Angeles Dodgers (1-0) in an NL West matchup at 10:10 p.m. ET on MLB Network.
Los Angeles rolled to an 8-2 win over Arizona on Opening Day and will look to clinch the three-game series tonight. Diamondbacks SP Ryne Nelson (4.05 xFIP in 2025) will take the mound against Dodgers SP Emmet Sheehan (3.37 xFIP in 2025) on Friday.
Let’s break down the matchup, make a Diamondbacks vs. Dodgers prediction, and circle a pair of player projections to target for MLB picks for PrizePicks.
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Diamondbacks vs. Dodgers Prediction, Spread, Over/Under
After the D-backs took a 2-0 lead in the fourth inning on Opening Day, the Dodgers answered with an 8-0 run to end the contest, proving why they are the World Series favorite. L.A. generated 5 runs thanks to 2 home runs from C Will Smith and OF Andy Pages.
Diamondbacks 2B Ketel Marte and OF Corbin Carroll combined for only 1 hit over 8 at-bats. Will the top of Arizona’s order improve for Game 2 of the three-game series?
Dodgers SP Emmet Sheehan started in only 12 games in the majors last season. This could be a more favorable matchup compared to facing Dodgers SP Yoshinobu Yamamoto in Game 1, who recorded a 2.72 xERA in 2025, per FanGraphs.
Diamondbacks vs. Dodgers Spread, Over/Under
The Diamondbacks enter Friday’s game as road underdogs, returning a 3.03x payout on PrizePicks Team Picks if they win outright.
The Dodgers are heavy home favorites with a 1.38x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Dodgers -1.5 (1.78x payout)
- Over/Under: 8.5 Runs (1.81x payout on over)
- Game Winner Payout: Diamondbacks 3.03x | Dodgers 1.38x
Team picks data is live as of publishing and is subject to change.
Diamondbacks vs. Dodgers Prediction on Spread – 3/27/26
Here are the key stats to know before locking in your Diamondbacks vs. Dodgers prediction on the spread for Friday, March 27, on PrizePicks.
- While Sheehan hasn’t dealt at Yamamoto’s level, he still posted an impressive 3.00 xERA and a 30.6% strikeout rate (92nd percentile) last season, per Baseball Savant.
- Arizona averaged only 8.1 strikeouts per game in 2025 (eighth-fewest) and continued that with 8 Ks on Opening Day.
- However, Sheehan’s 10.92 K/9 from last season could still cause problems.
- The Dodger starter allowed only 0.86 HR/9 a season ago, and the D-backs record 1.32 big flies per game in 2025 (eighth-most).
- Diamondbacks SP Ryne Nelson’s 3.93 xERA from last season isn’t quite as favorable.
- He finished in the 12th percentile for hard-hit rate allowed last season (45.5%), and Los Angeles had the fourth-highest hard-hit percentage in 2025.
- Nelson could lack help in the bullpen, too, with Arizona’s relievers finishing 27th with a 4.37 xERA last year.
Diamondbacks vs. Dodgers Picks for PrizePicks Today: 3/27/26
Check out a pair of Diamondbacks vs. Dodgers MLB picks to target for Friday, March 27, on PrizePicks. Diamondbacks 2B Ketel Marte and Dodgers SP Emmet Sheehan headline player stat projections via PrizePicks.
Diamondbacks 2B Ketel Marte vs. Dodgers Projection: 1.5 Hits+Runs+RBIs
- Marte batted .314 in away games compared to .254 at home last season.
- The switch hitter posted an absurd .342 batting average on the road vs. right-handed hurlers in 2025.
- Sheehan heavily leaned on a four-seam fastball with a 46.8% usage rate a season ago.
- Marte rakes against fourseamers with a .301 career batting average when facing the pitch.
- Furthermore, the veteran second baseman finished in the 83rd percentile of barrel rate in 2025, while Sheehan was in the 20th percentile for barrel percentage allowed.
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Dodgers SP Emmet Sheehan vs. Diamondbacks Projection: 5 Strikeouts
- Over 15 appearances in 2025, Sheehan posted 5.9 strikeouts per outing.
- Arizona finished 15th in chase rate at the plate last season, and the 26-year-old Dodger pitcher boasted an excellent 32.8% chase percentage in 2025 (91st percentile).
- Sheehan averaged 5.0 innings pitched per start last season. Another quality start could help elevate his K total tonight.
- His 3.00 xERA and 3.37 xFIP from 2025 round out his chances for a quality start to open the 2026 season.
Make Diamondbacks vs. Dodgers Picks on PrizePicks
Following a six-run win on Thursday night, are the Dodgers bound for another comfortable win? Marte could be key to sparking this Diamondbacks batting order vs. Sheehan.
You can make your Diamondbacks vs. Yankees picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
Stick around with the Playbook for continued MLB predictions, picks, and news throughout the 2026 season.
