Cubs vs. Cardinals Prediction, MLB Picks for Monday, July 27

The Chicago Cubs and St. Louis Cardinals are set to begin a four-game series on Monday, July 27 at 7:45 p.m. ET. In the first game of the series between these NL Central teams, the Cubs are slight road favorites, returning a 1.78x payout to secure a victory on PrizePicks Team Picks.

Chicago and St. Louis have met six times this season already, and the Cardinals have won four of those clashes.

Below, we'll break down our Cubs vs. Cardinals prediction and picks for Monday’s MLB contest, including the run line, over/under, and key player picks for PrizePicks.

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Cubs vs. Cardinals Prediction, Winner Payout, Over/Under – Monday, July 27

To get the series underway on Monday, it will be Cubs SP David Peterson (4.36 xFIP across 89.0 IP), while the Cardinals had yet to determine a starter as of Monday morning.

Over his 12 starts and 8 relief appearances, Peterson is in the 14th percentile in xERA (5.26) and eighth percentile in xBA (.279), per Baseball Savant. He also isn’t much of a swing-and-miss pitcher, as he ranks in the 35th percentile in chase rate (29.0%), 22nd percentile in whiff rate (21.5%), and 19th percentile in strikeout rate (18.2%).

On both the Cubs and the New York Mets, Peterson has experienced rough outings, but he’s given up a combined 1 ER across his last two starts.

Although the Cardinals haven’t announced a starter, SP Matthew Liberatore (4.31 xFIP across 99.0 IP) would be the projected starter if we’re going by the same date as Peterson for their last starts.

Along with beating the Pittsburgh Pirates in a three-game series over the weekend, the Cubs have produced the second-best wRC+ (122), third-best wOBA (.349), and second-best ISO (.192) over the last 30 days, per FanGraphs.

On top of the Cardinals losing three straight series, they’ve posted the third-worst wRC+ (74), wOBA (.277), and ISO (.117) in the same sample.

Ahead of Monday’s matchup, Chicago has the fifth-lowest payout to make the playoffs (1.07x) with a 59-46 record, while St. Louis has the 11th-highest payout (4.76x) in the same market with a 53-52 record.

Cubs vs. Cardinals Winner Payout, Over/Under – Monday, July 27

The Cubs enter Monday’s game as a road favorite against the Cardinals, returning a 1.78x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cubs vs. Cardinals game on PrizePicks.

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Team Picks data is live at the time of writing and is subject to change.

Cubs vs. Cardinals Prediction on Over/Under – 7/27/26

Here are the key game stats and trends behind our Cubs vs. Cardinals prediction on the winner for Monday, July 27.

• Peterson pitched against the Cardinals on July 3, and he permitted 10 ER and 9 hits in 3.2 IP.
• Additionally, Peterson started vs. the Cardinals when he was still on the Mets on June 10, surrendering 6 ER and 7 hits in 3.2 IP.
• With Peterson’s short outings against St. Louis, it’s worth noting that Chicago’s bullpen has tallied the seventh-worst xERA (4.55) and ninth-worst HR/9 (1.37) over the last month.
• The Cardinals have been solid against southpaws, recording the 14th-best wRC+ (96) and second-lowest strikeout rate (18.0%) in that split.
• Meanwhile, the Cubs have notched the 10th-best wRC+ (100), 9th-best wOBA (.319), and 12th-best ISO (.163) when playing on the road.
• Chicago has the 11th-highest hit rate on the Over when playing against a divisional opponent (55.2%), per TeamRankings.

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Cubs vs. Cardinals Picks, Player Stats for PrizePicks: 7/27/26

Here are the top Cubs vs. Cardinals picks to target on Monday, July 27. Today’s MLB picks for PrizePicks include David Peterson and Seiya Suzuki.

Cubs SP David Peterson vs. Cardinals: 2.5 Earned Runs Allowed

• Peterson has given up 3+ ER in five of his last eight starts.
• On top of his other below-average metrics, Peterson is in the 35th percentile in walk rate (9.4%) and 18th percentile in hard-hit rate (43.3%).
• The Cardinals have scored 3 or more runs in 16 of their 23 games in July.

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Cubs RF Seiya Suzuki vs. Cardinals: 6.5 Hitter Fantasy Score

• Since the start of July, Suzuki has a 153 wRC+, .395 wOBA, and .307 ISO.
• Over his last 10 games, Suzuki has combined for 3 HRs, 10 RBI, 9 runs, and 2 doubles.
• If Liberatore ends up being the starter for the Cardinals, Suzuki has a 166 wRC+, .415 wOBA, and .250 ISO against left-handed hurlers.
• St. Louis’ relievers have the eighth-worst xFIP (4.49) and 13th-worst WHIP (1.37) in the last month.

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David Peterson has struggled when facing the Cardinals this year. Could there be a decent number of runs when the Cubs and Cardinals square off at Busch Stadium on Monday?

Don’t wait until the first pitch — make your Cubs vs. Cardinals picks on PrizePicks now and earn real money if you’re right.

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