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Cubs vs. Braves Prediction, MLB Picks for Tuesday, May 12

Cubs 3B Alex Bregman walks to the dugout vs. the Guardians.
AP Photo/Sue Ogrocki

The National League’s top two teams open a three-game series on Tuesday, May 12, as the Chicago Cubs (27-14) visit the Atlanta Braves (28-13) with first pitch slated for 7:15 p.m. ET. According to PrizePicks Team Picks, the Braves enter Tuesday night’s game as the favorite with a 1.75x payout if they win.

Following a 10-game winning streak, the Cubs come off back-to-back losses against the Rangers. After a 2-1 series loss vs. the Mariners, the Braves bounced back with a 2-1 series win over the Dodgers.

Below, we'll break down our Cubs vs. Braves prediction and picks for Tuesday’s MLB game, including the winner payouts, over/under, and key player picks for PrizePicks.

Make your Cubs vs. Braves picks on PrizePicks now.

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Cubs vs. Braves Prediction, Winner, Over/Under – Tuesday, May 12

The Cubs vs. the Braves may be the series of the week, as the two sit atop the NL standings. According to PrizePicks Team Picks, Atlanta (5.26x) and Chicago (6.66x) have the second- and third-shortest payouts to win the National League, behind the Dodgers’ 2.22x payout.

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FanGraphs tabs both batting orders as some of the best in baseball, as the Braves’ 228 runs scored is first, while the Cubs aren’t far behind with 215 runs (fourth). Additionally, Atlanta (.346) and Chicago (.341) sit first and third in wOBA. The Braves’ 120 RC+ tops MLB, and the Cubs are tied for second with 119 wRC+.

Cubs SP Colin Rea (3.59 xFIP over 5 starts and 38.0 IP) and Braves SP Grant Holmes (4.58 xFIP over 7 starts and 37.1 IP) are tasked with facing elite batting orders on Tuesday.


Cubs vs. Braves Winner Payout, Over/Under – Tuesday, May 12

The Braves enter Tuesday’s game as a home favorite against the Cubs, returning a 1.75x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cubs vs. Braves game on PrizePicks.

  • Spread: Atlanta Braves -1.5 (2.5x payout)
  • Over/Under: 8.5 (1.72x payout on Over)
  • Game Winner Payout: Cubs 2x | Braves 1.75x

Play the Cubs vs. Braves winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.


Cubs vs. Braves Prediction on Over/Under – 5/12/26

Here are the key game stats and trends behind our Cubs vs. Braves prediction for the run total on Tuesday, May 12.

Lock in your Cubs vs. Braves prediction on PrizePicks before first pitch.

  • The Cubs have recorded 5.2 runs per game (third), compared to the Braves’ 5.6 runs per contest (first).
  • Chicago SP Colin Rea allows an 8.5% barrel rate (42nd percentile) and a 46.6% hard-hit rate (15th percentile), per Baseball Savant.
  • The Braves’ batting order is loaded with slugging, proven by a .454 xSLG (tied for first), a 9.9% barrel rate (fifth), and a 41.4% hard-hit rate (eighth).
  • Rea has also given up a .270 xBA (22nd percentile), and Atlanta boasts a .261 xBA (second).
  • The Cubs’ bullpen has stumbled, too, sporting a 4.48 xERA (24th).
  • Focusing on Braves SP Grant Holmes, he’s been torched by power hitting, surrendering 1.45 HR/9, a 7.9% barrel rate (49th percentile), and a 43.0% hard-hit rate (31st percentile).
  • Plus, Holmes ceded 4 HRs while compiling a 5.74 ERA over his last three starts.
  • Chicago has the power to take advantage, supported by 1.2 big flies per game (sixth). 

Cubs vs. Braves Player Picks, Stats for PrizePicks – 5/12/26

Here are top Cubs vs. Braves picks to target on PrizePicks for Tuesday, May 12. Today’s MLB picks for PrizePicks include Michael Conforto and Grant Holmes.

Cubs DH Michael Conforto vs. Braves Projection: 1.5 Hits + Runs + RBIs

  • Michael Conforto is exclusively featured against right-handed pitchers, and he’s been as good as it gets with an absurd .372 batting average in the split.
  • If eligible, Conforto’s .328 xBA, .589 xSLG, 15.6% barrel rate, and 53.1% hard-hit rate would all be among some of the best marks in baseball.
  • Brave SP Grant Holmes has a strong 32.6% chase rate (68th percentile), but Conforto rarely swings outside the strike zone with a minuscule 16.4% chase percentage.
  • Furthermore, Conforto rakes to the tune of .353 and .500 against four-seam fastballs and sliders — which make up Holmes’ most-used pitches.
  • Over his last three games, Chicago’s left-handed hitter amassed 6 hits, 3 runs, and 2 RBIs. That produces an average of 3.7 combined hits, runs, and RBIs per game in the split.

Add Michael Conforto to your PrizePicks Lineup now.

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Braves SP Grant Holmes vs. Cubs Projection: 2.5 Earned Runs Allowed

  • Grant Holmes has given up 2.6 earned runs per start this season.
  • He’s allowed 4.0 earned runs per appearance over his last two outings, and Holmes surrendered at least 3 earned runs in three of his last four starts.
  • As mentioned, the Cubs could have a good chance of going yard tonight. Atlanta’s right-handed hurler allows a 13.6% home run-to-fly ball ratio (HR/FB) that’s above the 10.8% league average.
  • Chicago touts a 39.9% fly ball rate (eighth) and carries an 11.9% HR/FB (tied for ninth).
  • Baseball Savant lists a four-seam fastball (37.5%) and a slider (37.3%) as Holmes’ most-used pitches, and the Cubs rank 10th and third for the most runs above average against the two pitches.

Add Grant Holmes to your PrizePicks Lineup now.


Make Cubs vs. Braves Picks on PrizePicks

Who will open a highly anticipated series with a win? The Cubs trail the Braves by only one game for first place in the National League. The scorekeepers could be busy tonight with two of the best batting orders in MLB colliding on Tuesday.

Don’t wait until the first pitch — make your Cubs vs. Braves picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 MLB season.

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Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Riley Thomas is a 2021 graduate of Ohio University who has worked for FanDuel Sportsbook and BetUS Sportsbook. He specializes in covering the NFL, NBA, college football, and college basketball. In Riley's free time, you can find him cheering on Ohio State and Kentucky or playing video games and reading the latest comics.

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