College football Week 2 officially gets started on Friday night with five games, as three ranked teams take the field, with #23 Missouri vs. Kansas ending the night in the Border War at 8 p.m. ET on FOX.
The college football schedule tonight kicks off with three games at 7 p.m. ET, including Villanova vs. #24 Louisville, Norfolk State vs. #25 Virginia, and Richmond vs. NC State
Below is the full Week 2 college football schedule for Friday’s game, how to watch or stream every NCAAF game, and current spreads via PrizePicks Team Picks — now available in 35 states!
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College Football Games Today: Week 1 Schedule, TV Channels, & Spreads
All game times are in Eastern Time. Spreads and winner payouts are live on PrizePicks Team Picks as of posting, but are subject to change.
Payouts below — like 3x — represent real-money multipliers on correct picks on PrizePicks Team Picks at the time of writing. For example, a $10 entry on Kansas to win at a 2.7x multiplier would pay out $27 if you're right.
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How to Watch NCAAF Game Tonight – Friday, September 11
With every game kicking off within a one hour window, all five games will be on different networks, with four games available on TV. Only Norfolk State vs. Virginia — the largest spread of the night at 45.5 points — will be available for streaming only on ACC Network Extra.
The main event of the evening will be on FOX, where the Border War between Missouri and Kansas is restored. Missouri won last year’s game in Columbia, Mo., 42-31, bringing the all-time record to 57-55-9 in favor of Missouri.
The rest of the games are broadcast on ESPN’s family of networks, though ESPN’s main coverage tonight will be on the US Open Men’s Semifinals, including an all-American semifinal between Francis Tiafoe and Ben Shelton.
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Week 2 NCAAF Spreads, Winners, Payouts Today on PrizePicks
Only two games tonight have a spread under 35 points; however, both of those games have spreads within one possession.
Missouri is favored by 5.5 points on the road vs. Kansas, while Boston College is a 3.5-point home favorite vs. Rutgers, who fell to UMass, 37-21, last week, despite entering as 29.5-point favorites.
The rest of CFB Week 2 is on the PrizePicks board now. In eligible states, you can make picks on college football winners, spreads, and totals. Then add Player Picks to the same lineup for bigger potential payouts.
For the first time ever, you can pick CFB winners on PrizePicks — now's the time to make your move.
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More Friday College Football Picks & Predictions Today
Need some expert picks and predictions before you lock in your college football lineup today? Tap into the Playbook’s Week 2 CFB research from our experts:
Week 2 CFB TD scorer predictions for Friday
Stay locked in on the Playbook college football home for daily picks, predictions, spreads, and game previews throughout the 2026 college football season.
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