Celtics vs. Knicks Picks, Predictions for Game 6 Tonight – 5/16/25

The NBA Playoffs continue on Friday with the Celtics fighting to stay alive in a crucial Game 6 against the Knicks, looking to take another game after losing SF Jayson Tatum for the season.

The Knicks can close it out with a win tonight in Madison Square Garden, or with a loss, they’;; be heading back to Boston or Game 7. We’ve got the top Celtics vs. Knicks picks and predictions for PrizePicks below, including Karl-Anthony Towns, Jaylen Brown, and Sam Hauser.

PrizePicks is the easiest way to add to the excitement of the NBA Playoffs and win real money. Pick More or Less on player stat projections — from points to assists — and get paid if your picks are correct. Get started on PrizePicks today and get a $50 bonus for free after your first $5 Lineup.

Let's dig into the top NBA player picks for Celtics vs. Knicks on Friday on PrizePicks!

Best Celtics vs. Knicks Picks, Predictions for Game 6

Here are three of the top NBA player picks for the Knicks vs. Celtics game today, May 16, on PrizePicks. Click to read more about each pick below.

• Knicks C Karl-Anthony Towns — 13.5 Rebs+Asts
• Celtics SF Sam Hauser — 5.5 Points  
• Celtics SF Jaylen Brown — 26 Points

Knicks C Karl-Anthony Towns — 13.5 Rebs+Asts

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• In his last 20 games, Karl-Anthony Towns has cleared 11.5 rebounds in only nine contests.
• Towns averaged 3.1 assists per game in the regular season, but he hasn’t had more than two in any Playoff game, and is averaging 0.4 assists per game in this series.
• In his most recent outing, Towns logged just 16 rebound chances over 36 minutes.
• Towns has gone less than this number in three of the last five games, and seven of the last 10.
• Boston ranks inside the top 10 in defensive rebounds allowed to the center position.
• The Celtics rank third overall in the NBA for rebounds allowed to opposing centers.

Celtics SF Sam Hauser — 5.5 Points

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• With Jayson Tatum sidelined for the remainder of the series, Sam Hauser is projected to see a significant increase in minutes. 
• In Game 5, he played 15 minutes.
• In his last 20 games playing more than 10 minutes, Hauser has surpassed 4.5 points in 18 contests — a 90% success rate.
• Hauser would also be the beneficiary of the Porzingis “illness” that has limited his minutes as well, as he can play the three and four.

Celtics SF Jaylen Brown — 26 Points

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• In 20 games without Tatum, Jaylen Brown has averaged 28 points per game
• Specifically against the Knicks, Brown has scored 26 points in those matchups, exceeding his 25.5-point projection.
• Brown has seen a four-minute increase in playing time and a +3 PPG bump without Tatum in his last 20 games.
• Brown has exceeded this projections in both games without Tatum in the 2025 Playoffs.

Cash in on. Celtics vs. Knicks on PrizePicks

The Celtics will try and force a Game 7 vs. the Knicks in the Eastern Conference Semifinals. With a Celtics’ win tonight, the series will head back to Boston for the final. This game between the Celtics and Knicks also leaves us with some appealing options to consider on PrizePicks.

There is a wide variety of player stat projections and picks on the board, so you can build your Lineup however you’d like — with no salary or positional restrictions. Just pick at least two player stat projections to build your Lineup on PrizePicks.

Check out our Playbook throughout the remainder of the NBA Playoffs for more analysis for your PrizePicks and NBA DFS Lineups.