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Entering Week 5 of the 2026 NFL season, a handful of matchups stand out, and players in those games just might be poised for notable performances. PrizePicks offers a variety of player projections to choose from each week, including pass attempts, rush yards, receptions, and more.
With plenty of stars in action, which ones could turn heads across Sunday’s contests?
Below, we'll bring you our best Week 5 NFL DFS picks for PrizePicks, where you can predict More or Less on player stats to earn real money if you're right!
Make your Week 5 NFL predictions and picks on PrizePicks!
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Week 5 NFL DFS Picks for PrizePicks – Sunday, October 11
Here are the top Week 5 NFL DFS picks to target on PrizePicks for Sunday, October 11. Today’s NFL picks include Aaron Jones Sr., Nico Collins, Aaron Rodgers, Brock Purdy, and Michael Wilson.
Stats in this article are courtesy of PFF or Sumer Sports unless stated otherwise.
Vikings RB Aaron Jones Sr. vs. Saints: 72.5 Rush Yards
- Jones has tallied 94 or more rushing yards in two of his last three starts with RB Jordan Mason inactive.
- With Mason sidelined, Jones has handled at least 17 carries in three straight games.
- The New Orleans Saints’ defense is dead last in rush EPA (0.08) and rushing success rate (52.7%) allowed, per RBSDM.
- Additionally, the Saints just coughed up a combined 207 rushing yards and 5 rushing TDs to Atlanta Falcons RBs Bijan Robinson and Brian Robinson in Week 4.
Pick Aaron Jones + Vikings to win on PrizePicks!
Texans WR Nico Collins vs. Titans: 5.5 Recs
- Collins made his return for the Houston Texans in Week 4, hauling in 7 of his 8 targets for 118 yards and 2 TDs.
- Collins has posted 7 receptions in each of his two starts in 2026.
- Among WRs with at least 50 routes run, Collins owns the eighth-highest target share (28.6%).
- With a lack of an effective rushing attack, the Texans are 12th in neutral pass rate (54.3%) through the first four weeks.
Pick Nico Collins + Texans to win on PrizePicks!
Steelers QB Aaron Rodgers vs. Colts: 34.5 Pass Attempts
- Rodgers has thrown the ball at least 39 times in three of his four starts in 2026.
- Furthermore, Rodgers has logged 39+ attempts in six of his last seven starts dating back to last season.
- With Mike McCarthy reuniting with Rodgers as head coach, the Steelers are sixth in neutral pass rate (58.3%).
- The Colts’ defense is 20th in dropback EPA allowed (0.09), so there’s no reason for Rodgers to refrain from airing it out this week.
Pick Aaron Rodgers + Steelers to win on PrizePicks!
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49ers QB Brock Purdy vs. Seahawks: 21.5 Rush Yards
- Purdy is using his legs when needed, achieving at least 29 rushing yards in all four starts.
- Among all QBs, Purdy has the fifth-most rushing attempts (20) to begin 2026.
- On top of that, he boasts the fourth-most yards per attempt (6.1) and third-most runs of 10+ yards (5) at the QB position.
- The Seattle Seahawks permitted 47 rushing yards to New England Patriots QB Drake Maye in Week 1 and 40 rushing yards to Los Angeles Chargers QB Justin Herbert in Week 4.
Pick Brock Purdy + 49ers to cover the spread on PrizePicks!
Cardinals WR Michael Wilson vs. Lions: 73.5 Rec Yards
- After totaling 74 receiving yards across the first two weeks of the season, Wilson has notched 89 or more yards in back-to-back games.
- Among WRs with 50+ routes run, Wilson has the sixth-highest target share (29.5%). Only TE Trey McBride has a higher target share (30.9%) on the Arizona Cardinals.
- The Detroit Lions’ defense is 30th in dropback EPA (0.29) and 31st in dropback success rate (53.0%) allowed.
- Plus, the Lions have given up at least 10 catches and 107 receiving yards to the opposing team’s top WR in three of their first four games.
Pick Michael Wilson + Cardinals to cover the spread on PrizePicks!
Make Week 5 NFL Picks on PrizePicks
Over on PrizePicks, there are endless options to choose from when it comes to NFL player projections in Week 5. Among the players taking the field on Sunday, October 11, the group of Jones, Collins, Rodgers, Purdy, and Wilson seems in favorable spots.
Ahead of Sunday’s action, it's time to lock in your NFL Week 5 picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
Stay locked in on Playbook for daily NFL news, picks, and news every day, all the way through Super Bowl LXI.
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