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On Thursday Night Football between the Pittsburgh Steelers and Cleveland Browns, players like RB Quinshon Judkins, RB Jaylen Warren, and WR DK Metcalf had standout performances. Following that high-scoring affair, there are 13 games on the horizon for Sunday’s Week 4 slate.
With plenty of stars in action in Week 4, which players stand out across Sunday’s contests?
Below, we'll bring you our top NFL DFS picks for PrizePicks, where you can predict More or Less on player stats to earn real money!
Make your Week 4 NFL predictions and picks on PrizePicks!
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Week 4 NFL DFS Picks for PrizePicks – Sunday, October 4
Here are the top Week 4 NFL DFS picks to target on PrizePicks for Sunday, October 4. Today’s NFL picks include Kyren Williams, Nico Collins, Aaron Jones Sr., Jeremiyah Love, and Brock Purdy.
Stats in this article are courtesy of PFF or SumerSports unless stated otherwise.
Rams RB Kyren Williams vs. Eagles: 58.5 Rush Yards
- RB Kyren Williams has scampered for 85 or more rushing yards in back-to-back games.
- Despite sharing the backfield workload with RB Blake Corum, Williams has the third-most yards per attempt (5.6) and 10th-most yards after contact per attempt (3.6) among RBs with 25+ carries.
- The Los Angeles Rams’ offense is seventh in rushing success rate (45.3%).
- Meanwhile, the Philadelphia Eagles’ defense is quietly 27th in rushing EPA (0.00) and 30th in rushing success rate (46.1%) allowed.
Pick Kyren Williams + Rams to win on PrizePicks!
Texans WR Nico Collins vs. Cowboys: 72.5 Rec Yards
- WR Nico Collins hasn't been limited in practice leading up to Sunday’s game against the Dallas Cowboys, so he seems to be a full go following a two-game absence.
- Collins has tallied at least 75 receiving yards in seven of his last 10 regular-season games, including in Week 1 against the Buffalo Bills.
- With Collins limited to one game in 2026, it’s worth noting that he had the fourth-most yards per reception (15.7) and ninth-most yards per route run (2.35) among WRs with 50+ targets in 2025.
- The Cowboys’ defense is 31st in dropback EPA (0.41) and 32nd in dropback success rate (58.9%) through Week 3.
Pick Nico Collins + Texans to cover the spread on PrizePicks!
Vikings RB Aaron Jones Sr. vs. Dolphins: 66.5 Rush Yards
- In the absence of RB Jordan Mason, RB Aaron Jones Sr. has logged a 79.7% snap share or higher and has earned at least 17 carries in consecutive weeks.
- Jones had 105 rushing yards in Week 2, and while he had 58 rushing yards in Week 3, that came against a Tampa Bay Buccaneers squad that is ceding the fourth-lowest rushing success rate (31.3%).
- This week, Jones will face a Miami Dolphins defense that's 14th in rushing success rate allowed (40.0%).
- The Minnesota Vikings are double-digit home favorites over the Dolphins in Week 4, and RB Demond Claiborne and RB DeeJay Dallas are the biggest threats for touches behind Jones.
Pick Aaron Jones Sr. + Vikings to win on PrizePicks!
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Cardinals RB Jeremiyah Love vs. Giants: 87.5 Rush + Rec Yards
- Rookie RB Jeremiyah Love earned a season-high 26 touches and 64.4% snap rate in Week 3.
- As a result, Love totaled 109 scrimmage yards (90 rushing yards, 19 receiving yards) against the San Francisco 49ers.
- After seeing a major boost in usage in Week 3, Love can see another uptick in playing time in Week 4 vs. the New York Giants.
- New York’s defense is 22nd in dropback success rate (49.6%) and 23rd in rushing success rate (42.9%) allowed.
Pick Jeremiyah Love + Cardinals to win on PrizePicks!
49ers QB Brock Purdy vs. Broncos: 233.5 Pass Yards
- QB Brock Purdy has thrown for 287 or more yards in back-to-back starts.
- Among 31 QBs with 50 or more dropbacks, Purdy has the second-most yards per attempt (9.5) and the sixth-highest adjusted completion percentage (80.0%).
- According to RBSDM, Purdy has the most adjusted EPA/play (0.63) and highest success rate (64.9%) of the 28 QBs with 50 or more plays.
- Since the beginning of last season, Purdy has registered at 287+ passing yards in five of his seven home starts.
Pick Brock Purdy + 49ers to cover the spread on PrizePicks!
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Make Week 4 NFL Picks on PrizePicks
Injuries continue to mount across the NFL, but there are still plenty of marquee players taking the field in Week 4. Among the endless options on PrizePicks, the group of Williams, Collins, Jones, Love, and Purdy are players to keep an eye on during Sunday’s games.
It's time to lock in your NFL picks on PrizePicks in Week 4. Just pick players, predict More or Less on their stats, and cash in on your predictions if you're right.
With PrizePicks Team Picks, make your predictions on NFL game winners, spreads, and over/unders — or combine one with players for even higher payouts.
Stay locked in on Playbook for daily NFL news, picks, and analysis all the way through Super Bowl LXI.
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