Best NFL TD Scorer Predictions for Week 1 – Sunday Slate, SNF, MNF

Week 1 of the 2026 NFL season has already seen several highlights, as the Seattle Seahawks took down the New England Patriots on opening night and the San Francisco 49ers thumped the Los Angeles Rams in Australia on Thursday. Ample points have been scored to this point.

Sunday’s slate of day games contains several high-profile matchups and windows for stars to find the end zone. Both Sunday Night Football and Monday Night Football also figure to see some bitter division rivals attempt to load the scoreboard against one another. Who may be in the best position to do so?

Below, we'll highlight our best NFL TD scorer picks for PrizePicks in NFL Week 1, including five players who could reach the end zone.

Make your NFL TD picks for Week 1 on PrizePicks now.

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Best Week 1 NFL TD Scorer Picks for PrizePicks

Whether it’s the Tampa Bay Buccaneers vs. the Cincinnati Bengals to kick off the slate on Sunday afternoon or the Denver Broncos taking on the Kansas City Chiefs on MNF, there’s a little bit of something for everyone when it comes to potential touchdown scorer picks. 

Player TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list player TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”

Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.

Here are the top NFL Week 1  TD scorer picks to target this weekend. Today’s NFL TD scorer picks for PrizePicks include RB Chase Brown, WR George Pickens, TE Dallas Goedert, and more.

Buccaneers vs. Bengals TD Scorer Prediction – 1 p.m. ET

Bengals RB Chase Brown: 0.5 Player TDs (Goblin)

• Brown tied his previous career high with 11 scrimmage TDs a season ago, also notching 1,456 scrimmage yards.
• The fourth-year halfback is a premier target for QB Joe Burrow in the passing game. Across all 17 regular-season outings last year, Brown hauled in 69 passes on 88 targets for 437 yards and 5 TDs.
• According to SumerSports, Brown’s 14.5% target share trailed only six other RBs in the league. 
• No team allowed more receiving yards to the RB position than the 2025 Buccaneers.

Add Chase Brown to your PrizePicks lineup now.

Cardinals vs. Chargers TD Scorer Prediction – 4:25 p.m. ET

Chargers RB Omarion Hampton: 0.5 Player TDs (Goblin)

• Hampton came on strong in his final four games last season, scoring in three of them, with one being through the air.
• Per NFL Pro, Hampton owned the #2 forced missed tackle clip at 30.6% among RBs with 100+ carries. Arizona had the second-highest missed tackle rate on defense at 17.2%. 
• In that same sample, Hampton logged the eight-highest late-down run success rate (70.6%). 
• Last year’s Cardinals surrendered more rushing yards (1,926) than all but three teams. They also tied for second-most in TDs with 17. 

Add Omarion Hampton to your PrizePicks lineup now.

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Commanders vs. Eagles TD Scorer Prediction – 4:25 p.m. ET

Eagles TE Dallas Goedert: 0.5 Player TDs (Goblin)

• After a down year, Goedert bounced back to record 60 catches for 591 yards and a personal best 11 TDs in 2025. 
• Goedert’s 10 red-zone TDs were tied for second along with Detroit Lions WR Amon-Ra St. Brown and Cardinals TE Trey McBride. Rams WR Davante Adams’ 12 led the league. 
• The veteran was also a major factor inside the 10-yard line, owning a staggering 40.9% target rate and an 88.9% catch percentage. 
• Washington struggled immensely against TEs a year ago, allowing them to score 12 TDs and produce 184.1 fantasy points, both the second-most in the sport. 

Add Dallas Goedert to your PrizePicks lineup now.

Cowboys vs. Giants TD Scorer Prediction – Sunday Night Football

Cowboys WR George Pickens: 1.5 Player TDs (Demon)

• Pickens experienced a full-fledged breakout last season, setting career highs in receptions (93), yards (1,429), TDs (9), and more.
• The former Pittsburgh Steelers standout was dominant after the catch, averaging 5.2 YAC per reception. 
• Out of all wideouts a campaign ago, Pickens’ 134.32 total receiving EPA was third. 
• Pickens was frequently targeted in the red zone by Dallas in 2025, finishing seventh with 21 and also being tied for eighth with 10 inside the 10-yard line. 

Add George Pickens to your PrizePicks lineup now.

Broncos vs. Chiefs TD Scorer Prediction – Monday Night Football

Broncos WR Jaylen Waddle: 1.5 Player TDs (Demon)

• In 11 games after Tyreek Hill went down with a season-ending injury, Waddle averaged just under 7 targets each week and had a whopping 15.4 yards per reception. 
• According to nfelo, Denver held the seventh-highest pass rate over expected at 1.6%. 
• Out of all WRs with 100+ routes in 2025, Waddle’s 2.19 yards per route run sat right inside the top 15. 
• Despite Waddle’s average depth of target rising to a career-high 13.2 yards, his drop rate was a career-low 4.5%, via Pro Football Focus.

Add Jaylen Waddle to your PrizePicks lineup now.

Make NFL Week 1 Picks on PrizePicks

Are you siding with a member of this group of five players, or is there someone else in mind regarding a potential Week 1 TD scorer? Either way, PrizePicks has plenty of options for football fans looking to make the most of a new season. 

Don’t wait until kickoff — make your NFL Week 1 picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats (like Player TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

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