Best MLB DFS Picks: Top Plays for PrizePicks MLB, 5/5/25

May 5, 2025

By: John Supowitz

Yankees OF Aaron Judge is a top MLB DFS pick today in the Yankees vs. Padres game, as he’s the top home run pick today on PrizePicks.

Evan Bernstein/Getty Images

After an exciting weekend of baseball, we have another smaller, but just as exciting slate on Monday. Below, we’ll focus on a few matchups that you will want to keep an eye on.

Monday’s best MLB DFS picks today include pitchers and hitters to target on PrizePicks, plus a home run prediction. The top games include the Padres vs. Yankees on MLB Network at 7:05 p.m. ET, and Freddie Freeman and the Dodgers vs. Marlins at 6:40 p.m. ET in a lopsided matchup.

Whether you’re riding with pitcher strikeouts or a hitter’s home run pick, the Monday MLB slate is stacked with opportunities to cash in on PrizePicks.

Don’t forget to head to the PrizePicks MLB board, lock in your picks, and submit your Lineup to get in on the real money MLB action before the first pitch.

Best MLB DFS Picks on PrizePicks: Monday, 5/5

Here are the best MLB DFS picks and predictions for PrizePicks today. Use this analysis to build your Lineups on PrizePicks MLB on Monday, May 5. Click to read more about each pick.

Marlins P Sandy Alcantara — 1.5 Earned Runs Allowed
Cardinals P Miles Mikolas — 17.5 Pitching Outs
Dodgers 1B Freddie Freeman – 3.5 Total Bases
Dodgers SS Mookie Betts – 0.5 RBI
White Sox OF Luis Robert – 0.5 Walks
Home Run Pick: Yankees OF Aaron Judge

Marlins P Sandy Alcantara — 1.5 Earned Runs Allowed (Goblin)

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Marlins P Sandy Alcantara allowed two or more earned runs in four straight starts.
He has a 4.64 ERA at home this season.
This Dodgers roster has a lifetime batting average of .321 in 152 plate appearances against Alcantara.
Alcantara has struggled against LHH this season, giving up a 5.88 xFIP. He’s expected to face at least three lefties in the Dodgers lineup.

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Cardinals P Miles Mikolas — 17.5 Pitching Outs

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Cardinals P Miles Mikolas has recorded less than 17 outs in five of six starts this season.
Mikolas is averaging a career-word 5.28 K/9 so far this season.
The Pirates' roster is hitting .304 in 146 career plate appearances against Mikolas.

Dodgers 1B Freddie Freeman – 3.5 Total Bases (Demon)

Dodgers 1B Freddie Freeman has gone over this projection in three of the last five games.
Since April 25th, he is batting .483 and has the second-most hits (14).
He is batting a career .320 with a .914 OPS in 92 games at Marlins Park.
He is batting a career .281 against Marlins projected starter Sandy Alcantara.
Alcantara is giving up 2.08 HR/9 and a 5.88 xFIP (7.46 FIP) to left-handed hitters this year.

Dodgers SS Mookie Betts – 0.5 RBI (Demon)

Dodgers SS Mookie Betts has the second-most RBI since April 25 with 10.
Betts has recorded an RBI in six consecutive games.
He has recorded six RBI in 16 career at-bats against Marlins starter Sandy Alcantara.

White Sox OF Luis Robert – 0.5 Walks (Demon)

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White Sox OF Luis Robert has the seventh-most walks in the league this season (20).
He has recorded a walk in six of his last nine games
His projected opposing starting pitcher, Royals P Cole Ragan, has allowed multiple walks in four of six starts this season.
Robert has two walks in three career plate appearances against Ragan.

Yankees OF Aaron Judge — 0.5 Home Runs (Demon)

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Yankees OF Aaron Judge has four home runs since April 25, the most in the league.
He is second in the league in home runs (11).
Of those 11 home runs, he has hit eight of them at Yankee Stadium, where he’ll face the Padres today.
Judge has two home runs in 18 career at-bats against projected Padres starter Nick Pivetta.

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Lock in on MLB DFS Today on PrizePicks

We have a choice of exciting games on the Monday MLB slate, including the Dodgers in an advantageous matchup against the Marlins. There’s no better time to participate in the action on PrizePicks. Just build your MLB Lineup on PrizePicks and win real money if your picks are correct.

All you need to do is pick More or Less on at least two player projections — like total bases or pitcher strikeouts — to win real cash.

Whether you go with demons or goblins, there’s always real money sports action waiting for you on PrizePicks. Stay locked in on the Playbook all season long for MLB player picks every day.