After a weekend clash between these two Spanish La Liga sides, Barcelona is set to host Atletico Madrid at the Camp Nou just four days later — except in this Champions League match, the stakes are higher.
Barcelona handed Atleti just their second home defeat in the Spanish top flight after a late goal by Robert Lewandowski broke the 1-1 deadlock on Saturday, for its third win in four matches against Atleti.
Just 96 hours later, the rivalry resumes, and we get to watch these Spanish clubs face off for the fifth time this season on Wednesday, April 8, at 3:00 p.m. ET on Paramount+.
Can Atletico Madrid rediscover a path to victory, or will Barcelona extend their 9-game unbeaten streak across all competitions?
Below, we’ll break down our Barcelona vs. Atletico Madrid prediction, picks, and projected lineups for Wednesday afternoon’s Champions League match.
Make your Champions League picks on PrizePicks and earn real money if you’re right, including on players, goal totals, game winners, and more!
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Barcelona vs. Atletico Madrid Prediction, Timeline for Champions League – Wednesday, April 8
Atleti manager Diego Simeone and his squad will be looking for their second victory over Barcelona this season when they travel to northeast Spain on Wednesday afternoon.
Atleti’s lone win versus the Spanish champions came in the Copa del Rey, which saw Los Rojiblancos blitz Barcelona in Spain’s capital, 4-0 — Barca's biggest loss of the season, and just the second time that the side hasn't scored in a match this season.
Atleti will look to repeat that performance here by getting off to a hot start; all four of those goals came in the first half.
Since that loss in mid-February, Barcelona has been on a tear, running through every opponent they’ve matched up with.
Manager Hansi Flick’s side went unbeaten in March, winning five of their six matches and drawing just once to Newcastle in the first leg of their UCL tie. They cruised to a 7-2 win in their second leg match vs. the Premier League side.
Looking at the other three fixtures between these Spanish sides, Barcelona has been the far superior team every time.
The Catalans went on to win the second leg of the previously mentioned Copa del Rey tie, 3-0, (ultimately losing 4-3 on aggregate), and also won the first La Liga matchup vs. Atleti, 3-1, back in December.
Despite both sides winning games against each other by large margins, these teams have been fairly evenly matched this season, with an 8-6 aggregate score in favor of Barcelona across their four matchups.
Flick will be without Brazilian star Raphinha in both of their remaining matches with Atletico Madrid, after the winger re-aggravated a lingering hamstring issue over the international break. Raphina has 27 goals+assists across all competitions this season.
Atletico Madrid will once again be without first-choice goalkeeper Jan Oblak, who has missed the last six games with a muscle injury. Oblak has only featured in the first matchup between these teams, but could possibly return in the second leg back at the Metropolitano next week.
Barcelona vs. Atletico Madrid Spread, Total Goals, Payouts
Barcelona enters Wednesday’s matchup as a significant home favorite, returning a 1.47x payout ($100 entry pays out $147) on PrizePicks Team Picks if they win outright.
PrizePicks Team Picks has the road team, Atletico Madrid, as heavy underdogs, with a 4.76x payout ($100 entry pays out $476) should they find a way to win this game.
Make your Barca vs. Atleti prediction on PrizePicks to earn real money if you're right.
- Winner Payout: Barcelona – 1.47x | Tie – 4.34x | Atletico Madrid– 4.76x
- Spread: Barcelona -1.5 (2.17x Payout)
- Total Goals: 3.5 (Over – 1.85x)
- Both Teams to Score: Yes 1.44x | No 2.63x
Team Picks data is live at the time of writing and is subject to change.
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Barcelona vs. Atletico Madrid Prediction on Total Goals
Here are the key match stats to know before making your prediction for Barcelona vs. Atletico Madrid total goals in the Champions League quarterfinal on Wednesday, April 8, on PrizePicks.
The under 3.5 total goals for Barcelona vs. Atletico Madrid is set at 1.88x ($100 pays out $188), with the over 3.5 goals set at 1.85x, on PrizePicks Team Picks — available in 35 states.
Check out more of our soccer picks and predictions on PrizePicks.
- Barcelona and Atletico Madrid have gone over 3.5 total goals in two of their four matchups this season.
- Atletico Madrid games have gone over 3.5 total goals three times over their last five games across all competitions.
- Barcelona has scored 3 or more goals in 10 of their 11 home games in 2026.
- These two teams have combined for 107 total shots in their four games this season. Of those 107, 41 have been on target.
- Barcelona has scored the most goals at home (13) in the Champions League this season.
- Atletico struggled as the away team in the UCL this season. Simeone’s squad won just one game with a 6-10 goal differential.
Barcelona vs. Atletico Madrid Projected Lineups for Wednesday, April 8
Take a look at the Barcelona vs. Atletico Madrid projected lineups for today's Champions League match. Lineups are not official and should be confirmed before match start.
Barcelona Lineup vs. Atletico Madrid: Projected 4-2-3-1
Goalkeeper: Joan Garcia
Defense: Joao Cancelo, Gerard Martin, Pau Cubarsi, Jules Kounde
Midfield: Pedri, Eric Garcia, Fermin Lopez
Forwards: Marcus Rashford, Robert Lewandowski, Lamine Yamal
Atletico Madrid Lineup vs. Barcelona: Projected 4-4-2
Goalkeeper: Juan Musso
Defense: Nahuel Molina, Robin Le Normand, David Hancko, Matteo Ruggeri
Midfield: Koke, Marcos Llorente, Antoine Griezmann
Forwards: Giuliano Simeone, Julian Alvarez, Ademola Lookman
Barcelona vs. Atletico Madrid Player Picks for Champions League Match – 4/8/26
Here are two top Barcelona vs. Atletico Madrid picks to target on players for Wednesday, April 8, for PrizePicks. Player picks for PrizePicks are headlined by Lamine Yamal and Juan Musso.
Barcelona F Lamine Yamal vs. Atletico Madrid Pick
Yamine Lamal Projections on PrizePicks: 0.5 Goal + Assist (Goblin), 5.5 Shots (Demon), 10.5 Attempted Dribbles
Make your pick on Yamine Lamal for today's UCL match on PrizePicks here.
- Lamine Yamal is amongst the top ten G/A leaders in the UCL this season with 9. The 18-year-old is top 6 in average shots per game (3.5) and top 10 in average shots on target per game (1.5).
- Yamal has recorded just one assist in the four matches vs. Atleti this season. He created a combined five big chances over the four games.
- The Spanish attacker averages 10.63 attempted dribbles per match in the Champions League this season. In four games vs. Atleti, the right-winger has averaged 14 attempted dribbles per match. He has not had fewer than 11 attempted dribbles in a game versus Atletico this season.
Atletico Madrid GK Juan Musso vs. Barcelona
Juan Musso Projections on PrizePicks: 4.5 Goalie Saves (Demon), 3.5 Goalie Saves (Goblin)
Make your pick on Juan Musso for today's UCL match on PrizePicks here.
- Juan Musso has started five games in La Liga this season, picking up three clean sheets, only conceding to Real Madrid and Barcelona.
- Musso has 32 saves in his last six games, including 16 saves in the previous three meetings between Barcelona and Atletico Madrid.
- Barcelona averages 7 shots on target per game in the Champions League. The Catalans had 47 total shots, with 21 being on target vs. Musso in the prior three games.
Make Your Barcelona vs. Atletico Madrid Prediction on PrizePicks
Barcelona will look to continue building on their impressive home record when they host Atletico Madrid on Wednesday, April 8, at 3 p.m. ET, for a Champions League match.
Atleti will hope to keep Barcelona as tame as possible, with the second leg back in Madrid in front of their fans.
You can make your Barcelona vs. Atletico Madrid prediction on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats like shots and passes, and cash in if you’re correct.
On Team Picks, you can make predictions on winners, total goals, and the Champions League winner, now available in 35 states.
Stick around with the Playbook for continued soccer and Champions League predictions, picks, and analysis.
