Atletico Madrid vs. Barcelona is set to kick off at 3:00 p.m. ET on Tuesday, April 14, with Barcelona entering as 1.69x favorites, via PrizePicks.
Barcelona’s Champions League hopes are swiftly dwindling after suffering a 2-0 defeat to Atletico Madrid at home in the first leg of this tie. The Catalans now travel to the Riyadh Air Metropolitano with an opportunity to reach the UCL Semifinals should they make an improbable comeback down 2 goals in a familiar, but hostile environment.
Below, we'll break down our Atletico Madrid vs. Barcelona prediction and picks for Tuesday's Champions League match, including the spread, total goals, and key player picks for PrizePicks.
Make your picks for Atletico Madrid vs. Barcelona on PrizePicks now.
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Atletico Madrid vs. Barcelona Prediction, Spread, Total Goals for Champions League – Tuesday, April 14
Barcelona surprisingly suffered its first home loss of the season last Wednesday at the hands of manager Diego Simeone and Atletico Madrid.
These two clubs are set to meet for the sixth and final time this season on Tuesday afternoon. While Barcelona has technically won three of the five matchups thus far, the teams have been uber-competitive with an aggregate score of 8-8.
The first leg followed that trend, with Barcelona excelling for much of the first half but unable to find the back of the net. A poor challenge from Hansi Flick’s defender, Pau Cubarsi, in the 42nd minute saw Barca drop to 10 men after he was shown a red card.
Atleti capitalized on the ensuing free kick, a beauty from F Julian Alvarez, that opened up the scoring in the first leg.
Despite the disadvantage, Barcelona tried its best to make a comeback in the second half, but to no avail. Atleti keeper Juan Musso finished the contest with 7 saves, bringing his tally against the Champions of Spain to 23 in four matches. Simeone and Co. hope for more of the same from the Argentine as they look to hold off Barcelona’s relentless attack.
That's easier said than done against one of the strongest attacks in the world. Following last week’s game, Barcelona went on to obliterate Espanyol 4-1 in La Liga over the weekend. F Lamine Yamal continued his world-class season with 2 assists and a goal, and Flick aims for more of this should his squad try to advance in this tournament.
Simeone decided to give all starters from last Wednesday’s match the weekend off when they took on Sevilla in La Liga. With their spot in the top four of the Spanish top flight all but decided, Atleti appears to be putting a greater emphasis on advancing to the UCL Semifinals for the first time since 2016-2017.
Atletico Madrid vs. Barcelona Spread, Total Goals, Payouts – Tuesday, April 14
Barcelona enters Tuesday’s game as road favorites against Atletico Madrid, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Atletico Madrid vs. Barcelona game on PrizePicks.
- Winner Payout: Atletico Madrid – 3.44x | Tie – 4x | Barcelona – 1.69x
- Spread: Barcelona -1.5 (2.7x Payout)
- Total Goals: 3.5 (Over – 1.81x)
- Both Teams to Score: Yes 1.35x | No 3.03x
Play the Atletico Madrid vs. Barcelona spread or total goals on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Atletico Madrid vs. Barcelona Prediction on Total Goals – 4/14/26
Here are the key game stats and trends behind our Atletico Madrid vs. Barcelona prediction on total goals for Tuesday, April 14.
Lock in your Atletico Madrid vs. Barcelona prediction on PrizePicks before the line moves.
- Atletico Madrid and Barcelona have gone over 3.5 total goals in just two of their five matchups. Each of the last three matches has gone under 3.5 total goals.
- Barcelona games have gone over 3.5 total goals just twice in its last five games across all competitions.
- Atletico Madrid hasn't conceded more than 2 goals at the Metropolitano in the calendar year.
- Barcelona’s away form has not been as strong since the start of February. The Catalans have scored 2 or fewer goals in six away matches. Barcelona’s last away game was a 2-1 victory over Atletico Madrid in La Liga 10 days ago.
- Simeone is the only coach in Champions League history to have not lost a home game in the UCL knockout stages. He's miraculously gone 20 home knockout games unbeaten.
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Atletico Madrid vs. Barcelona Projected Lineups for Tuesday, April 14
Take a look at the Atletico Madrid vs. Barcelona projected lineups for Tuesday's Champions League match. Lineups are not official and should be confirmed before match start.
Atletico Madrid Lineup vs. Barcelona: Projected 4-3-3
Goalkeeper: Juan Musso
Defense: Nahuel Molina, Robin Le Normand, Clement Lenglet, Matteo Ruggeri
Midfield: Koke, Marcos Llorente, Antoine Griezmann
Forwards: Giuliano Simeone, Julian Alvarez, Ademola Lookman
Barcelona Lineup vs. Atletico Madrid: Projected 4-2-3-1
Goalkeeper: Joan Garcia
Defense: Joao Cancelo, Jules Kounde, Ronald Araujo, Eric Garcia
Midfield: Pedri, Frankie de Jong, Fermin Lopez
Forwards: Marcus Rashford, Robert Lewandowski, Lamine Yamal
Atletico Madrid vs. Barcelona Player Picks, Stats for PrizePicks: 4/14/26
Here are top Atletico Madrid vs. Barcelona picks to target on PrizePicks for Tuesday, April 14. Today’s Champions League picks for PrizePicks include Lamine Yamal and Juan Musso.
Barcelona F Lamine Yamal vs. Atletico Madrid
Lamine Yamal Projections via PrizePicks: 0.5 Goals + Assists, 4.5 Shots, 4 Crosses
- Lamine Yamal has 5 goals and assists in his last five games for Barcelona across all competitions. The Spanish winger recorded 0.19 xG and 0.53 xA in the first leg against Atleti.
- Yamal has a combined 24 shots attempted in his last five games. In five matches vs. Atletico, the 18-year-old has 17 total shots (3.4 per game).
- Barcelona’s #10 is averaging 3 crosses per game in the Champions League. In his five games versus Atletico Madrid, Yamal averages 4.2 crosses per game, including 14 total in the three matches this calendar year.
Add Lamine Yamal to your PrizePicks Lineup now.
Atletico Madrid GK Juan Musso vs. Barcelona
Juan Musso Projections via PrizePicks: 3.5 Goalie Saves, 28.5 Passes Attempted
- Musso has had Barcelona’s number, averaging 5.75 saves in four games against the Champions of Spain.
- The Argentine has 26 saves in his last five games, with half of them coming against Barcelona alone.
- The 32-year-old goalkeeper has had fewer than 28.5 passes attempted in three of his last five matches. With Barcelona down two goals, Musso could be given more goal kicks than normal after failed attacks by the Catalans. Musso had 12 goal kicks in the first leg alone.
Add Juan Musso to your PrizePicks Lineup now.
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Make Atletico Madrid vs. Barcelona Champions League Picks on PrizePicks
Barcelona looks to accomplish something no other team has done against Simeone when they travel to face Atletico Madrid on Tuesday, April 14, at 3:00 p.m. ET. Atletico, meanwhile, aims to hold on to a 2-goal cushion and advance to the Champions League Semifinals.
Don’t wait — you can make your Atletico Madrid vs. Barcelona picks now on PrizePicks and PrizePicks Team Picks to earn real money.
Just pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and total goals, now available in 35 states.
Stick around with the Playbook for continued soccer and Champions League predictions, picks, and analysis.
