76ers vs. Pacers Prediction, Spread, NBA Picks – Wednesday, October 28

The Philadelphia 76ers look to bounce back from their first loss, heading to Gainbridge Fieldhouse to face the Indiana Pacers on Wednesday, October 28 at 7 p.m. ET on ESPN. 

The Sixers (3-1) won the first three games of the LeBron James era before scoring a season-low 93 points in Sunday’s 13-point home defeat to Detroit. 

Indiana (2-2) has alternated wins and losses in its first four games since the return of star PG Tyrese Haliburton. The Pacers were tripped up by the Bucks 110-102 on Monday, suffering their first road loss in three tries.

Below, we'll break down our 76ers vs. Pacers prediction and picks for Wednesday's NBA game, including the winner, spread, over/under, and key player picks for PrizePicks.

Make your 76ers vs. Pacers prediction on PrizePicks now.

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76ers vs. Pacers Prediction, Spread, Over/Under – Wednesday, October 28

The 76ers enter Wednesday’s game as 4.5-point road favorites against the Pacers. If Indiana wins outright, it returns a 2.5x payout via PrizePicks Team Picks.

Here are the full payouts for the 76ers vs. Pacers game on PrizePicks.                       

PrizePicks data is live at the time of writing and is subject to change.

Make your 76ers vs. Pacers prediction on spread, over/under, and more on PrizePicks!

The Pacers squandered an 11-point halftime lead in Monday’s defeat at Milwaukee, getting outscored 60-41 in the second half. Indiana is never afraid to fire away from deep, but the Pacers hit only 13 of 48 3-point attempts (27.1%).

Head coach Rick Carlisle’s team has shot below 30.0% from downtown in three of four games, with the lone outlier coming in Sunday’s win at Brooklyn, hitting 21 of 43 attempts.

Haliburton ranks 43rd in the league in 2-point shooting percentage (62.9%). According to Hoops Junkie, the former Iowa State star has attempted the third-most 2-pointers (35) among players in the top 50 in this category (Phoenix SG Devin Booker and Toronto SG-SF RJ Barrett).

However, Haliburton is now slated to miss time with a left hamstring strain. Does that open the door for Philadelphia even more?

James started at center in Sunday’s loss to the Pistons, in place of the resting Joel Embiid on the second leg of a back-to-back. After James sat out Saturday’s victory over Milwaukee, he posted a team-worst defensive rating of 122.1 against Detroit.

Taking it a step further, James owns a lower offensive rating (100.9) on the court than off compared to the team's mark, while his defensive rating is 10.8 points worse than Philly's when he's on the bench.

SF Jaylen Brown has been an absolute positive for Philadelphia on both sides of the court. The former Celtics standout is +39 on, while the Sixers are -27 when he's out of the game. He also has at least 13-point on-off swings in both offensive and defensive rating.

76ers vs. Pacers Prediction on Winner – 10/28/26

Here are the key game stats and trends behind our 76ers vs. Pacers prediction on the winner for Wednesday, October 28.

• The 76ers swept the Pacers last season, winning all four meetings as Haliburton was sidelined recovering from an Achilles injury.
• Philadelphia owns the fourth-lowest effective field goal percentage (eFG%) in the league at 48.0%, according to NBA.com.
• The Sixers have taken care of the basketball, posting the lowest turnover rate at 12.2%. Meanwhile, Indiana ranks 23rd in defensive turnover rate at 14.0%.
• The Pacers are listed as an underdog for the first time after closing in the favorite role in the first four games.
• Indiana’s first four opponents own a combined 3-11 record, including victories over winless Brooklyn and New Orleans.

Lock in your 76ers vs. Pacers prediction on PrizePicks before tonight’s NBA game.

76ers vs. Pacers Picks, Player Stats for PrizePicks: 10/28/26

Here are the top 76ers vs. Pacers picks to target on Wednesday, October 28. Today’s NBA picks for PrizePicks include Tyrese Maxey and Pascal Siakam.

76ers PG Tyrese Maxey vs. Pacers: 22.5 Points

• The additions of Brown and James haven’t hurt Maxey’s scoring average, which is at 28.8 PPG through four games.
• According to databallr, Maxey sits in the 83rd percentile in scoring turnover clip at 5.0%. This analytic measures how often a player gives the ball away when trying to score — lower is better.
• The former Kentucky standout led the Sixers in usage rate in three of four games. In Sunday’s loss to Detroit, Maxey’s usage was a season-high 35.7%, but Embiid also sat out.
• Only one opposing PG has scored at least 23 points against Indiana (Dallas PG Kyrie Irving). The final point guard to eclipse this projection against the Pacers last season was Maxey, who posted 32 points in a 105-94 road victory.

Add Tyrese Maxey + 76ers to win to your PrizePicks lineup now.

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Pacers F Pascal Siakam vs. 76ers: 29.5 Pts + Rebs

• Siakam posted his first double-double of the season against Milwaukee, scoring 20 points and grabbing 13 rebounds.
• The former Raptors All-Star is averaging 31.3 combined points and boards through four games; each opponent owns a defensive rating of 19th or lower (76ers are fourth). 
• Siakam has compiled the highest usage rate for any Pacer in all four contests, including more than 30% in two wins over the Pelicans and Nets. 
• The 76ers have allowed the most rebounds per game (53.8), and Siakam has recorded at least 7 boards in three of four outings. 

Add Pascal Siakam + Pacers to cover the spread to your PrizePicks lineup now

Make 76ers vs. Pacers Picks on PrizePicks

Philadelphia tries to rebound from its first loss of the season. Can the new-look 76ers bounce back tonight against the Pacers, who are seeking their first home victory?

Don’t wait until tip-off — make your 76ers vs. Pacers picks on PrizePicks now and earn real money if you’re right.

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