Trail Blazers vs. Lakers Prediction, Spread, NBA Picks – Tuesday, October 27

October 27, 2026

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NBA
AP Photo/Craig Mitchelldyer
Trail Blazers G Damian Lillard and Ja Morant celebrate following a bucket vs. the Suns.

Trail Blazers vs. Lakers is set for tip off at 11:00 p.m. ET on Tuesday, October 27, with the Lakers being 3.5-point favorites for the spread, via PrizePicks.

Something will have to give in this matchup with the Lakers (3-0) and Trail Blazers (2-0) undefeated. Both teams have thrived offensively, with the Lakers averaging 128.0 points per game and the Trail Blazers putting up 126.0 points per night.

Below, we’ll break down our Trail Blazers vs. Lakers prediction and NBA picks for Tuesday's matchup on NBC and Peacock, including the spread, over/under, and key player picks for PrizePicks.

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Trail Blazers vs. Lakers Prediction, Spread, Over/Under – Tuesday, October 27

The Lakers enter Tuesday’s game as a 3.5-point home favorite against the Trail Blazers, via PrizePicks.

Here are the full payouts for the Trail Blazers vs. Lakers game. PrizePicks data is live as of writing and is subject to change.

Win Spread Over/Under
POR Trail Blazers 2.12x +3.5 | 1.81x o233.5 | 1.81x
LAL Lakers 1.66x -3.5 | 1.92x u233.5 | 1.88x
Make your Trail Blazers vs. Lakers prediction on the spread on PrizePicks.

This is the first game of a back-to-back set for the Lakers, who have a road game Wednesday against the Clippers.

With star PG Luka Doncic leading the way, Los Angeles has the best offensive rating in the league (125.9), per NBA.com. Being healthy has also helped their cause; they have no significant injuries heading into this matchup.

The Trail Blazers put up 124 points in their season opener against the Suns, then won 128-120 over the Kings on Friday. They will be fresh having the last three days off, which is good news for veteran PG Damian Lillard.

After missing all last season while recovering from a torn Achilles, Dame played 24 and 33 minutes in the first two games. In total, he shot 14 for 30 from the field.


Trail Blazers vs. Lakers Prediction on Spread – Tuesday, October 27

Here are the key game stats and trends behind our Trail Blazers vs. Lakers prediction on the spread for Tuesday, October 27.

  • The Lakers won all three of their games by at least 8 points, scoring at least 125 points in each matchup.
  • Including the playoffs, Los Angeles went 28-18 ATS at home last season. That was the fourth-best home record ATS in the NBA.
  • The Trail Blazers were 21-24 ATS on the road last season, including the playoffs.
  • Although Portland went 2-1 versus Los Angeles last season, Doncic did not play in any of the three games.
  • Over 21 career games against the Trail Blazers, Doncic averaged 31.0 points. 8.3 rebounds, and 8.3 assists.
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Trail Blazers vs. Lakers Picks, Player Stats for PrizePicks: 10/27/26

Here are top Trail Blazers vs. Lakers picks to target on PrizePicks for Tuesday, October 27. NBA picks for PrizePicks include Trail Blazers PG Damian Lillard and Lakers SG Austin Reaves.

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Trail Blazers PG Damian Lillard vs. Lakers: 19.5 Points

  • Lillard scored 25 and 19 points in his first two games of the season. Of his 30 shot attempts, 20 came from behind the arc.
  • Dame played only 24 minutes in his season opener against the Suns, but that’s because Portland won by 41 points. He logged 33 minutes against the Kings on Friday.
  • The hefty 3-point shooting volume for the veteran guard is noteworthy because he shoots 37.1% from behind the arc for his career.
  • The Trail Blazers were ninth in the league in pace of play (101.63) last season. They have a similar pace (101.50) through their first two games.
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Lakers SG Austin Reaves vs. Trail Blazers: 23.5 Points

  • Reaves enters this matchup with back-to-back games with at least 28 points. He is averaging 26.7 points after providing 23.3 points a night last season.
  • The star shooting guard is averaging 9.7 free throw attempts through three games, which is up from 7.3 per contest last season.
  • An increase in free throw attempts can be key for Reaves because he shoots 86.6% from the charity stripe for his career.
  • The 28-year-old has a 25.4% usage rate as Doncic’s main running mate with F LeBron James now on the 76ers.
  • Reaves usually spends a lot of time on the floor, posting back-to-back seasons in which he averages at least 35 minutes. He played at least 36 minutes in two of three games this year.
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The Lakers will try to continue their dominance at home and extend their season record to 4-0 when they host the Trail Blazers. Reaves has the potential to continue to score in bunches, while Lillard could use his 3-point shooting prowess to have a productive night in the scoring column.

Don’t wait until tip off — make your Trail Blazers vs. Lakers picks on PrizePicks now and earn real money if you’re right.

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Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.