The Detroit Pistons (46-18) return home to face off against the Philadelphia 76ers (35-30) in an Eastern Conference showdown on Thursday, March 12.
The Pistons and 76ers have played one another twice this season, with Detroit coming away with a win on both occasions. Tip-off for Thursday’s matchup is scheduled for 7:00 p.m. ET on Prime Video, with the hosts listed as hefty 15.5-point favorites.
Below, we’ll break down our 76ers vs. Pistons prediction and picks for Thursday night’s game. Make your NBA picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!
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76ers vs. Pistons Prediction, Spread, Over/Under
The Pistons have been one of the best teams in the NBA throughout the 2025-26 season. Detroit currently sits atop the Eastern Conference with a 3.5-game lead over the Boston Celtics following a 138-100 win against the Brooklyn Nets on Tuesday.
Pistons PG Cade Cunningham has produced an MVP-worthy campaign and really developed into a true superstar. Since the All-Star break, Cunningham has put together averages of 24.2 points, 11.4 assists, and 5.7 rebounds while shooting 45.3% from beyond the arc.
Meanwhile, the 76ers have been plagued by injuries lately. PG Tyrese Maxey (finger), C Joel Embiid (oblique), and SF Kelly Oubre Jr. (elbow) are all out, on top of SF Paul George serving a 25-game suspension.
Philadelphia currently sits in eighth place in the Eastern Conference and could wind up in one of the play-in tournament spots. The 76ers did come away with a 139-129 win against the Memphis Grizzlies in their most recent game.
76ers vs. Pistons Spread, Over/Under
The Pistons are 15.5-point home favorites tonight, returning a 1.08x payout on PrizePicks Team Picks if they win outright.
The 76ers are hefty road underdogs and return a 7.14x payout if they win outright, per PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Detroit Pistons -15.5 (1.96x payout)
- Over/Under: 222.5 (1.96x payout)
- Game Winner Payout: 76ers 7.14x | Pistons 1.08x
Team Picks data is live as of writing and is subject to change.
76ers vs. Pistons Injury Report
Let’s dive into the full 76ers vs. Pistons injury report for Thursday, via NBA.com.
Philadelphia 76ers Injury Report
- C Adem Bona (back): OUT
- C Andre Drummond (back): Questionable
- C Joel Embiid (oblique): OUT
- PG Tyrese Maxey (finger): OUT
- SF Kelly Oubre Jr. (elbow): OUT
Detroit Pistons Injury Report
- SF Bobi Klintman (coach's decision): OUT
- SF-SG Caris LeVert (wrist): OUT
- SF Ausar Thompson (ankle): OUT
76ers vs. Pistons Prediction on Spread – 3/12/26
Here are the key stats to know before locking in your 76ers vs. Pistons prediction against the spread for Thursday, March 12, on PrizePicks.
- The Pistons have an 11-16 against-the-spread record as a home favorite, producing a 40.7% cover rate.
- The 76ers are 1-4-1 ATS in their last six games.
- Detroit allows the third-fewest points per game (109.6) in the NBA, also holding its opponents to a 34.9% shooting clip from deep (fifth).
- Philadelphia makes 46.0% of its shots on a nightly basis, ranking 23rd in the league.
- The Pistons have recorded a +7.3 average scoring differential, second in the league behind only the Oklahoma City Thunder (+10.9).
76ers vs. Pistons Picks for PrizePicks Today: 3/12/26
Here are two of the top 76ers vs. Pistons picks to consider for Thursday, March 12. Today's PrizePicks NBA player picks feature C Jalen Duren and G VJ Edgecombe.
Pistons C Jalen Duren vs. 76ers Projection: 29.5 Pts + Rebs
- Duren has averaged a combined 33.9 points and rebounds in his last 10 games.
- The Pistons' star big man has racked up at least 30 points and rebounds in seven of his last 10 contests.
- Duren has averaged 11.2 RPG since the All-Star break.
- According to NBA Advanced Stats, Duren secures 45.4% of his contested rebound opportunities.
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76ers G VJ Edgecombe vs. Pistons Projection: 28.5 Pts + Rebs + Asts
- Edgecombe has put up a combined average of 27.7 points, rebounds, and assists across his last 10 games.
- The 2025 lottery pick has tallied at least 29 points, rebounds, and assists in six of his last eight contests.
- Edgecombe scored 21 points on 7-of-15 shooting, also grabbing 5 rebounds and dishing out 5 assists vs. the Grizzlies on Tuesday without Maxey and Embiid.
- Per databallr, Edgecombe spends 22.5% of his time on the court on-ball, ranking in the 85th percentile. That percentage may increase with Maxey out of the lineup.
Make 76ers vs. Pistons Picks on PrizePicks
The Pistons sit atop the Eastern Conference standings and are looking to create some distance between themselves and the Celtics. Meanwhile, an injury-riddled 76ers team aims to land in the win column for the second consecutive game.
You can make your 76ers vs. Pistons picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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