#15 Utah vs. Iowa State Prediction, Spread, NCAAF Picks – Saturday, September 26

The #15 Utah Utes vs. Iowa State Cyclones game is set to kick off at 3:30 p.m. ET on Saturday, September 26 at Jack Trice Stadium in Ames, Iowa. The Utes enter as 7.5-point road favorites, via PrizePicks. The game will be televised nationally on FOX.

Utah (3-0) has allowed a total of 24 points and covered the point spread in all three victories. The Utes blanked state rival Utah State 33-0 as 26.5-point favorites last Saturday to win their ninth straight game since October 2025.

Iowa State (2-1) owns a pair of blowouts over Southeast Missouri State and Bowling Green but lost to Iowa 16-13 as 14.5-point road underdogs. The Cyclones seek their fourth consecutive Big 12 win after beating TCU, Kansas, and Oklahoma State to close out 2025.

Below, we'll break down our Utah vs. Iowa State prediction and picks for Saturday's college football game, including the winner, over/under, and key player picks for PrizePicks.

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#15 Utah vs. Iowa State Prediction, Spread, Over/Under – Saturday, September 26

The Utes are one of six Big 12 teams owning a 3-0 record heading into this weekend’s action. Utah and ISU are two of 10 squads that have not faced a conference opponent yet as the Utes have allowed the fewest points of any Big 12 club.

From a defensive standpoint, Utah ranks sixth nationally in EPA per pass and fourth in EPA/rush (both are best in the Big 12). The Utes are first in the country in Net Adjusted EPA/play, according to Game on Paper, led by QB Devon Dampier with a total EPA of 18.46 (last season was 93.04).

Iowa State has turned in stronger numbers on the defensive side through three games. The Cyclones have yielded 33 points, capped off by last week’s 55-7 rout of Bowling Green.

ISU is right behind Utah in defensive EPA/rush among Big 12 teams (sixth nationally). The Cyclones have faced the 101st (Iowa) and 122nd-ranked (Bowling Green) squads in EPA/rush; Utah sits 25th in that category.

This is probably the toughest test for Utah before its showdown against BYU on November 7. The Utes host Kansas, visit Colorado, welcome Houston, and head to Cincinnati following this trip to Ames.

There won’t be any cyclones going through Jack Trice Stadium on Saturday, but there is a strong chance of rain early in the morning. Field conditions may not be optimal for this Big 12 opener.

Utah vs. Iowa State Spread, Over/Under – Saturday, September 26

The Utes enter Saturday’s game as 7.5-point favorites against the Cyclones. Iowa State returns a 3.44x payout if it wins outright, via PrizePicks Team Picks.

Here are the full payouts for the Utah vs. Iowa State game on PrizePicks.

Play the Utah vs. Iowa State winner or over/under on PrizePicks.

Team Picks data is live at the time of writing and is subject to change.

Utah vs. Iowa State Prediction on Spread – 9/26/26

Here are the key game stats and trends behind our Utah vs. Iowa State prediction on the spread for Saturday, September 26.

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• This marks only the third meeting since 2010 and the second as Big 12 foes.
• The Cyclones rallied late in a 31-28 triumph in Salt Lake City two years ago, but the Utes grabbed the cover as 6.5-point home underdogs.
• The Utes have finished with a total EPA of 20.0 or higher in all three wins and held their opponents to an EPA of -9.00 or lower.
• Iowa State ranks last in the Big 12 in passing yards per game (151.3) but sits in the middle of the league in yards per attempt (8.4).
• Utah has compiled an incredible 12-4 against-the-spread (ATS) mark since the start of 2025.
• The Cyclones are listed as a home underdog for the first time since November 2023, falling to Texas 26-16 as 7.5-point dogs.

Utah vs. Iowa State Picks, Player Stats for PrizePicks: 9/26/26

Here are top Utah vs. Iowa State picks to target on Saturday, September 26. Today’s college football picks for PrizePicks include QB Devon Dampier and RB Aiden Flora.

Utah QB Devon Dampier vs. Iowa State: 220.5 Pass Yards

• Dampier topped the 250-yard passing mark in each of the last two games against Arkansas and Utah State.
• His highest yardage output came against the Razorbacks, throwing for 261 yards on a 224.5-yard projection. Arkansas’ defensive EPA/pass ranks 106th in the country.
• The Cyclones allowed at least 221 passing yards to five of nine QBs in conference play last season.
• Utah’s EPA/dropback ranks 36th, which is a major jump for ISU, which has faced 83rd-ranked Iowa and 105th-ranked Bowling Green in this category. 

Add Devon Dampier + Utah to win to your PrizePicks lineup now.

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Iowa State RB Aiden Flora vs. Utah: 79.5 Rush Yards

• Flora enters this week tied for 10th in the nation with 328 rushing yards.
• The sophomore has seen his numbers increase each week. After a 45-yard performance in the opener, he ran for 89 yards against Iowa before busting out for 194 in the Bowling Green blowout.
• With that said, not a single RB has rushed for more than 41 yards against Utah this year. 
• Utah’s run defense is elite and is now facing an Iowa State rushing attack that ranks 97th nationally in success rate (41.0%). 

Add Aiden Flora + Iowa State to cover the spread to your PrizePicks lineup now.

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The Utes and Cyclones have both been excellent defensively thus far. Who will come out on top in this Big 12 opener with potentially suboptimal weather conditions?

Don’t wait until lock — make your Utah vs. Iowa State picks on PrizePicks now and earn real money if you’re right.

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