Wyoming vs. San Jose State Prediction, Spread, NCAAF Picks – Friday, October 9

Week 6 of the 2026 college football season continues Friday night as the Wyoming Cowboys travel to take on the San Jose State Spartans in a Mountain West matchup.

Wyoming enters the game at 2-3 after suffering a 28-0 loss to North Dakota State last weekend, while San Jose State is 3-2 following a 20-16 road victory over Hawaii.

Can the Cowboys bounce back offensively and keep this game competitive on the road, or will QB Luke Weaver and the Spartans build upon last week’s result to secure another conference victory?

San Jose State enters the 9 p.m. ET matchup on CBS Sports Network as a 4.5-point home favorite, with the total sitting at 42.5 points.

Below, we'll break down our Wyoming vs. San Jose State prediction and picks for Friday's college football game, including the spread, over/under, and top player projections for PrizePicks.

Make your Wyoming vs. San Jose State picks on PrizePicks now!

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Wyoming vs. San Jose State Prediction, Spread, Over/Under – Friday, October 9

San Jose State enters Friday's game as a 4.5-point favorite against Wyoming, returning a 1.49x payout if it wins outright.

Here are the full payouts for Wyoming vs. San Jose State on PrizePicks.

Make your Wyoming vs. San Jose State prediction on the spread or over/under on PrizePicks.

Payouts show potential returns on correct Team Picks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

Neither team here is particularly impressive. College Football Ratings ranks the Spartans 115th nationally in overall team rating, compared with Wyoming at 127th. Both teams have struggled to establish themselves as consistent offensive forces, but San Jose State has been far more productive through the air.

Weaver played his cleanest game of the season and got his revenge last week after transferring from Hawaii. He finished the game 19-for-28 with 2 TDs and 0 INTs, posting a season-high 165.2 passer rating in the process.

San Jose State is 3-2-0 ATS (against the spread) entering this clash.

Wyoming hasn’t been a passing threat; QB Tyler Hughes has surpassed 200 passing yards only once in his five starts and owns an atrocious 2:6 TD:INT ratio. This team would much prefer to keep the ball on the ground, as it has 169 rushes to 113 passes on the year.

Defensively, Wyoming hasn’t been any better. It sits 116th nationally in EPA/rush (0.16) and 78th in EPA/dropback (0.12). The Cowboys' inconsistency on both sides has led to a 1-4-0 ATS record.

Wyoming vs. San Jose State Prediction on Spread – 10/9/26

Here are the key stats and predictions behind our Wyoming vs. San Jose State spread prediction for Friday, October 9.

Unless otherwise noted, data used in this article is from College Football Ratings, PFF, or Game on Paper.

• San Jose State has the stronger overall efficiency profile, slotting in at 79th nationally in net EPA/play at -0.04, while Wyoming is 125th at -0.22.
• The Cowboys rank 119th nationally in offensive EPA/play (-0.15) and 133rd in EPA/pass (-0.26). I struggle to see how they'll generate offense tonight, especially if they fall behind by multiple scores.
• Wyoming's offense produces a 42.3% success rate, good for just 89th nationally. San Jose State's defense allows a 45.2% success rate, ranking 80th.
• Wyoming's defense cedes good plays in droves, posting a 50.0% success rate against (123rd). It also ranks 128th in average third-down distance faced.
• San Jose State's defense allows a 60.9% red-zone TD rate, which would typically be a concern, but this Wyoming offense converts 34.8% of its red-zone opportunities into TDs, fourth worst in the country.
• The Spartans are 57th nationally in EPA/dropback (+0.27); Wyoming's defense is 90th under the same umbrella.
• Wyoming's best chance to stay competitive might be through the ground game. The Cowboys rush on 55.1% of their offensive plays (36th) and average 4.5 yards per rush. However, San Jose State allows just 4.0 yards per rush (66th) and is 56th in EPA/rush ceded (0.0).

Lock in your Wyoming vs. San Jose State prediction on PrizePicks.

Wyoming vs. San Jose State Picks, Player Stats for PrizePicks: 10/9/26

Here are the top Wyoming vs. San Jose State picks to target on Friday, October 9. Today's college football picks for PrizePicks include Tyler Hughes and Luke Weaver.

Wyoming QB Tyler Hughes vs. San Jose State: 148.5 Pass Yards

• Hughes is completing just 58.9% of his passes, and his 6.3 yards per attempt reflects an offense that's struggled to produce consistent passing efficiency.
• The Cowboys' starting QB nets 141.6 passing YPG and has cleared this projection in just two of his five appearances.
• Hughes' 6 INTs are another concern because turnovers and stalled drives can keep Wyoming from sustaining offensive possessions.
• The Spartans' defense has been solid against the pass, ranking 63rd in EPA/dropback (0.05).

Add Tyler Hughes + Wyoming to win to your PrizePicks lineup now.

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San Jose State QB Luke Weaver vs. Wyoming: 234.5 Pass Yards

• Weaver is completing 62% of his passes and has cleared this projection in all but one start in 2026 (he finished with 234 yards against USC). 
• San Jose State’s offense has a 46% passing success rate (56th) compared to just a 36% rushing success rate (121st).
• Wyoming's defense is 90th in EPA/dropback and 112th in passing success rate allowed.
• As a 4.5-point favorite, the game script might not favor the Spartans building a massive lead and running the ball to sit on it, so Weaver might take to the air early and often.

Add Luke Weaver + San Jose State to cover the spread to your PrizePicks lineup now.

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It isn’t the most thrilling Friday game, but there are still opportunities to capitalize on throughout. 

Can Weaver take advantage of Wyoming's defensive struggles and lead San Jose State to a comfortable home win, or will Hughes and the Cowboys keep the score close?

Don’t wait until kickoff — make your Wyoming vs. San Jose State picks on PrizePicks now and earn real money if you’re right.

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