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Bye weeks are a new factor to consider in fantasy football entering Week 5, with the Kansas City Chiefs and Carolina Panthers off this week.
Along with needing to keep an eye on bye weeks, it’s crucial to monitor injury updates throughout the week to make start/sit fantasy football lineup decisions.
If you tend to stress over lineup decisions or wait until the last minute, look no further than our Week 5 fantasy football rankings.
Below, we’ll highlight the best fantasy football options at each position in Week 5, including quarterbacks, running backs, wide receivers, tight ends, and defense/special teams.
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All fantasy football rankings below use PrizePicks NFL fantasy scoring, which includes one point per reception (PPR). Players who historically catch more passes should get a slight discount if you are in non-PPR leagues.
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Week 5 Quarterback Rankings
Here are our Week 5 quarterback rankings for the 2026 fantasy football season.
Make NFL Week 5 predictions on PrizePicks — including pass yards and TDs!
Week 5 Running Back Rankings
Here are our Week 5 running back rankings for the 2026 fantasy football season.
Make NFL Week 5 predictions on PrizePicks — including rush yards and TDs!
Week 5 Wide Receiver Rankings
Here are our Week 5 wide receiver rankings for the 2026 fantasy football season.
Make NFL Week 5 predictions on PrizePicks — including receiving yards and TDs!
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Week 5 Tight End Rankings
Here are our Week 5 tight end rankings for the 2026 fantasy football season.
Week 5 Defense/Special Teams Rankings
Here are our Week 5 defense and special teams rankings for the 2026 fantasy football season.
Make NFL Week 5 predictions on PrizePicks — including sacks and teams to win!
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Make NFL Week 5 Predictions on PrizePicks
Injury news to keep tabs on ahead of kickoff in Week 5 includes QB Lamar Jackson, QB Jayden Daniels, RB D’Andre Swift, RB Kyle Monongai, RB Rhamondre Stevenson, WR Ja’Marr Chase, WR Justin Jefferson, WR Tee Higgins, WR DeVonta Smith, WR Malik Nabers, and WR Ladd McConkey.
You can track all the latest player news updates, including who is in and out, on Playbook
With Week 5 of the 2026 NFL season set to kick off, which players should you insert in your fantasy football lineups?
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