Valkyries vs. Fever Prediction, Spread, WNBA Picks for Friday, May 22

The Golden State Valkyries vs. Indiana Fever game is set to tip off at 7:30 p.m. ET on Friday, May 22, with the Fever entering as 6.5-point favorites on the spread from PrizePicks Team Picks.

The Valkyries (3-1) head to Indianapolis with no rest tonight after routing the Liberty 87-70 as 5.5-point underdogs. Golden State showed no signs of rust following a week off, jumping out to a 10-point lead after one quarter and never looking back.

The Fever (3-2) seek a third straight win following double-digit home victories over Seattle and Phoenix. The big question heading into tonight’s matchup is whether star G Caitlin Clark will suit up after missing Wednesday’s win over the Mercury with a back injury.

Below, we'll break down our Valkyries vs. Fever prediction and picks for Friday’s WNBA game, including the spread, over/under, and key player picks for PrizePicks.

Make your Valkyries vs. Fever picks on PrizePicks now.

{{wnba_offer_banner="/style-system/ui-components-playbook"}}

Valkyries vs. Fever Prediction, Spread, Over/Under – Friday, May 22

There were questions about how competitive Golden State would be heading into their expansion campaign in 2025. The Valkyries responded by overcoming a 2-5 start to capture the final playoff spot at 23-21 before getting eliminated by Minnesota.

Golden State hasn’t let up early this season, compiling three wins of 10+ points against Seattle, Phoenix, and New York. The only hiccup came in a 69-63 home defeat to Chicago, squandering an early 12-point lead.

Meanwhile, Clark missed her first game of the season on Wednesday, seeing her get ruled out one hour prior to tip-off. Indiana led by as many as 26 points in a 90-73 rout of expansion team Portland as C Aliyah Boston paced the Fever with 24 points.

In Indiana’s two losses, it yielded at least 100 points against the Wings and Mystics. In both defeats, Clark shot a combined 9-of-26 (34.6%) from the floor compared to 14-of-27 (51.8%) shooting in triumphs over the Sparks and Storm.

Valkyries vs. Fever Spread, Over/Under – Friday, May 22

The Fever enter Friday’s game as 6.5-point home favorites against the Valkyries, returning a 1.36x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Valkyries vs. Fever game on PrizePicks.

• Spread: Indiana Fever -6.5 (1.81x payout)
• Over/Under: 165.5 (1.58x payout on Over)
• Game Winner Payout: Valkyries 3.03x | Fever 1.36x

Make your Valkyries vs. Fever prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Valkyries vs. Fever Injury Report for Friday, May 22

Let’s dive into the full Valkyries vs. Fever injury report for Friday, May 22, via WNBA.com.

Golden State Valkyries Injury Report

• None

Indiana Fever Injury Report

• G Caitlin Clark - Probable

Valkyries vs. Fever Prediction on Winner – 5/22/26

Here are the key game stats and trends behind our Valkyries vs. Fever prediction on the winner for Friday, May 22.

Lock in your Valkyries vs. Fever prediction on PrizePicks now.

• The Valkyries posted a perfect 3-0 record against the Fever last season, including an 80-61 blowout at Gainbridge Fieldhouse.
• In the two games Clark played against Golden State, she was held to 10 and 11 points while hitting 2 of 12 attempts from deep.
• Since last season, the Fever are 2-5 against the spread (ATS) in their last seven games as a home favorite.
• The Valkyries own a 31-18-1 ATS mark since coming into existence, tied with Atlanta for the best record in this stretch.
• Golden State takes care of the ball well, ranking first in the WNBA with the lowest turnover rate at 12.2%. It’s a huge improvement from the 18.5% rate in 2025, which was 12th.
• The Valkyries live and die from deep with 42.9% of their points coming from 3-point range. In each of the last two games, Golden State converted 15 field goals apiece.
• Indiana hit 17 of 42 3-point attempts in an overtime loss to Washington. In the other four games, the Fever knocked down just 29% of their 3-point tries. 

Valkyries vs. Fever Picks, Player Stats for PrizePicks: 5/22/26

Here are the top Valkyries vs. Fever picks to target on Friday, May 22. Today’s WNBA picks for PrizePicks include G Kelsey Mitchell and F Gabby Williams.

Fever G Kelsey Mitchell vs. Valkyries: 21.5 Points

• Mitchell is fifth in the WNBA in scoring at 23.0 PPG, slightly behind Clark (24.3 PPG) for the team lead.
• In the first game without Clark on Wednesday, Mitchell scored 21 points on a season-low 11 field goal attempts.
• The former Ohio State standout didn’t eclipse 16 points in three matchups with Golden State in 2025, capped off by a 7-of-30 shooting slump in the final two losses.
• Mitchell topped this projection in each of the first three games but fell short in each of the past two outings.

Add Kelsey Mitchell to your PrizePicks Lineup now.

{{wnba_offer_banner="/style-system/ui-components-playbook"}}

Valkyries F Gabby Williams vs. Fever: 15.5 Points

• Williams leads Golden State averaging 15.0 PPG, a nice bump from 11.6 PPG in Seattle last season.
• The ex-UConn star bounced back from a 7-point effort in the opening night win over the Storm with 16 or more points in each of the past three games.
• In three matchups against Indiana last season, Williams put up 8.3 PPG, highlighted by a 12-point performance in a 78-74 defeat.
• The Fever have allowed 10 players to score at least 16 points this season.

Add Gabby Williams to your PrizePicks Lineup now.

Make Valkyries vs. Fever Picks on PrizePicks

Golden State has a quick turnaround following last night’s blowout of New York. Can the Valkyries improve to 4-0 lifetime against the Fever tonight?

Don’t wait until tip-off — make your Valkyries vs. Fever picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

Stay locked in on Playbook for daily WNBA predictions, picks, and news every day all the way through the 2026 WNBA Finals.