#21 UCLA vs. #13 Oregon Prediction, Spread, NCAAF Picks – Saturday, October 10

Week 6 of the college football season brings a major Big Ten showdown as the #21 UCLA Bruins travel to Autzen Stadium to take on the #13 Oregon Ducks. For Saturday's 3:30 p.m. ET kickoff on CBS, PrizePicks tabs Oregon as a 10.5-point favorite for the spread.

UCLA enters Saturday's matchup undefeated (4-0) after a dominant start to the season, while Oregon is 3-1 following a 41-27 victory over USC. The Bruins have been one of the country's most effective rushing teams, but they'll face a significant test against in a challegening road environment vs. Oregon.

Below, we'll break down our UCLA vs. Oregon prediction and picks for Saturday's Week 6 CFB game, including the spread and player picks for PrizePicks.

Make your UCLA vs. Oregon picks on PrizePicks now!

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#21 UCLA vs. #13 Oregon Prediction, Spread, Over/Under – Saturday, October 10

Oregon enters Saturday's game as a 10.5-point favorite against UCLA, returning a 1.21x payout if they win outright — or a $121 return on a $100 entry if you're right.

Here are the full payouts for UCLA vs. Oregon on PrizePicks. PrizePicks data is live at the time of writing and is subject to change.

Make your UCLA vs. Oregon prediction on the spread on PrizePicks!

UCLA has been one of college football's biggest surprises this season, ranking third nationally in raw offensive EPA per play at +0.39, according to Game on Paper.

The Bruins also rank seventh in overall success-rate differential and 13th in yards-per-play differential, highlighting how effectively they've moved the ball through the first four games.

The rushing attack has been particularly impressive. UCLA averages 281.5 rushing yards per game and has scored a whopping 18 rushing TDs. RB Wayne Knight has been the standout performer, rushing for 445 yards and 9 TDs on just 49 carries.

Oregon, meanwhile, has faced a much tougher schedule. The Ducks have already beaten one ranked team, USC, with their only loss against Oklahoma State. 

Oregon's biggest question mark is at quarterback. Dante Moore is out after suffering a concussion against USC, leaving Dylan Raiola to take over the starting role. Raiola was fantastic against USC, completing 19 of 25 passes for 289 yards and 2 TDs, giving the Ducks plenty of reason to believe their offense can keep producing.

This game will be played at Autzen Stadium, where Oregon has historically been extremely difficult to beat. The Ducks have won their last five meetings with UCLA and eight straight home games vs. the Bruins, making this the most challenging test of the season for the undefeated visitors.

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UCLA vs. Oregon Prediction on Spread for Week 6 – 10/10/26

Here are the key stats and predictions behind our UCLA vs. Oregon spread prediction for Saturday, October 10.

Unless otherwise noted, data used in this article is from College Football Ratings, Game on Paper, or PFF.

• The Bruins have the more direct path to offensive success with their run game. UCLA ranks first in the nation in EPA/rush (0.40) and will now take on an Oregon defense that sits 101st in EPA/rush (0.10)
• The advanced offensive numbers also favor UCLA. The Bruins rank third nationally in raw offensive EPA per play (+0.39), while Oregon is 18th in net EPA per play (+0.20).
• RB Wayne Knight is a major reason for UCLA's offensive success and can help UCLA put together methodical drives. He averages 9.1 yards per attempt and has a 63.3% rushing success rate, making him one of the country's most productive backs.
• UCLA QB Nico Iamaleava adds another dimension to its rushing attack. He's contributed 178 rushing yards on 28 carries. His mobility makes the Bruins more difficult to defend, as opponents must account for both Knight and the quarterback on designed runs and read-option plays.
• Oregon's quarterback situation adds uncertainty for the Ducks. Raiola's performance against USC was encouraging, but UCLA presents a much tougher challenge. The Bruins' defense ranks 14th nationally in EPA/pass (-0.18).
• UCLA also has a major advantage on third down on both sides of the ball. Offensively, the Bruins are 29th in average third-down distance (6.38 yards), while the Ducks rank 122nd defensively (6.05).
• Defensively, the Bruins rank 11th in average third-down distance (8.40 yards), while the Ducks offense sits 53rd (6.77 yards).

Lock in your UCLA vs. Oregon prediction on PrizePicks before Saturday's CFB game.

UCLA vs. Oregon Picks, Player Stats for PrizePicks – 10/10/26

Here are two UCLA vs. Oregon player picks to consider for Saturday's Big Ten showdown. Today's CFB picks for PrizePicks focus on UCLA QB Nico Iamaleava and Oregon QB Dylan Raiola.

UCLA QB Nico Iamaleava vs. Oregon: 185.5 Pass Yards

• Iamaleava is averaging 205 passing yards per game but now faces a Ducks defense that is far more vulnerable to the run than the pass.
• UCLA's rushing attack could limit Iamaleava's passing volume. The Bruins are averaging 281.5 rushing yards per game and will have plenty of incentive to keep the ball on the ground against Oregon, which ranks 101st in EPA/rush (0.10).
• The Bruins' passing efficiency has been less impressive than their rushing numbers. Iamaleava has a 41.1% passing success rate (90th), while the run game ranks second nationally with a 54.3% success rate.
• Iamaleava’s own legs can also limit his passing volume. The Bruins QB has rushed the ball 35 times himself, with decent success (4.1 YPC). 

Add Nico Iamaleava to your PrizePicks lineup now.

Oregon QB Dylan Raiola vs. UCLA: 290.5 Pass Yards

• Raiola enters this matchup after completing 19 of 25 passes for 289 yards and 2 TDs against USC. His 76.0% completion rate showed he can operate efficiently in Oregon's offense, even as a “backup.” The former 5-star recruit is far from the normal backup QB.
• Oregon has averaged 346.5 passing yards per game entering Saturday, giving the Ducks a productive passing game that can exploit a UCLA defense that surrenders 225.8 passing yards per game.
• Oregon's receiving options set up the young quarterback well. The Ducks have multiple players who can generate explosive plays, including WR Dakorein Moore and TE Jamari Johnson, who average 16.7 and 16.0 yards per reception, respectively.
• The best QB the Bruins have faced is California's QB Jaron-Keawe Sagapolutele, who threw for 271 yards while playing the entire second half on a bum ankle.
• While tough to quantify, this is also a massive game for Raiola’s future prospects, and he likely knows that. If he can perform in place of Dante Moore, Raiola can work his way into legitimate first-round NFL conversations, and while it’s certainly a stretch, he could even steal the job as the Ducks QB1 outright if Moore struggles when he returns.

Add Dylan Raiola to your PrizePicks lineup now.

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Make UCLA vs. Oregon Picks on PrizePicks

The Big Ten takes center stage Saturday afternoon as the undefeated #21 UCLA Bruins travel to Autzen Stadium to face the #13 Oregon Ducks.

Can Nico Iamaleava and UCLA's dominant rushing attack pull off a road upset and remain undefeated? Or will Dylan Raiola and the Ducks capitalize on their home-field advantage to hand the Bruins their first loss of the season?

Don't wait until kickoff — make your UCLA vs. Oregon picks on PrizePicks. There is a wide variety of player stat projections on the CFB board, so you can make predictions on yards, touchdowns, and more! Just pick your players, predict More or Less on their stats, and cash in on your predictions if you're right.

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