The Vikings and Texans — two of the top five units in the NFL in terms of fewest points allowed per game — are the only teams with a bye in Week 6. That means plenty of players will have the potential to feast on some of the league's worst defenses, including when Rams QB Matthew Stafford takes on the Ravens.
Packers QB Jordan Love and RB Josh Jacobs could also thrive vs. the Bengals
Below, we'll discuss Stafford, Love, and Jacobs, and get into more of the top NFL DFS picks for Week 6, including some quick picks for PrizePicks.
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Quick PrizePicks Picks for NFL Week 6
Here are some quick PrizePicks DFS picks for NFL Week 6, including projections for pass yards, rush yards, and receiving yards.
Panthers QB Bryce Young vs. Cowboys Projection: 218.5 Pass Yards
- The Panthers might need to throw a lot in this matchup to keep up with the Cowboys, who are averaging 30.2 points per game.
- That could work in Young's favor, as the Cowboys have allowed 272.2 passing yards per game.
Packers RB Josh Jacobs vs. Bengals Projection: 79.5 Rush Yards
- Jacobs has received at least 19 carries, and has run for at least 84 yards in three of his four games.
- Entering Week 6, the Bengals have allowed the fourth-most rushing attempts (153) and the eighth-most rushing yards per game (132.2) in the league.
Buccaneers WR Emeka Egbuka vs. 49ers Projection: 72.5 Receiving Yards
- Egbuka has recorded at least 85 receiving yards in each of the last three games.
- With Mike Evans (hamstring) out for the last two contests, the Buccaneers’ explosive rookie posted 11 receptions for 264 yards and 2 TDs on 17 targets.
NFL DFS Week 6 Predictions, NFL Picks for Sunday
Here are the top NFL DFS picks for NFL Week 6. Player projections via the PrizePicks real money NFL game.
Rams QB Matthew Stafford vs. Ravens Projection: 256.5 Pass Yards
- Rams QB Matthew Stafford has thrown for at least 375 yards in each of his last two games.
- The veteran has an average target depth of 9.0 yards, which is on pace to be his highest mark since 2020 when he was still with the Lions.
- The Rams’ star WR duo of Puka Nacua and Davante Adams have a total of just 4 drops this year.
- According to 4for4 Football, the Ravens have the fourth-highest pass EPA per play allowed in the league.
Packers QB Jordan Love vs. Bengals Projection: 29.5 Pass Attempts
- Packers QB Jordan Love has attempted 25 or fewer passes in two of his four games.
- Last season, the former first-round pick averaged 28.3 pass attempts per game.
- Of the Packers’ 11 wins last season, six came by at least 10 points. Love played in five of those victories, jacking up fewer than 30 passes in four of them.
- The Bengals sport the worst point differential (-71) in the NFL.
Raiders RB Ashton Jeanty vs. Titans Projection: 73.5 Rush Yards
- Per RotoWire, Raiders RB Ashton Jeanty has a 68.3% positive run rate and has averaged 3.5 yards after contact. Both of those marks rank inside the 93rd percentile in the league.
- The standout rookie showed his immense upside against the Bears in Week 4, rushing 21 times for 138 yards and 1 TD.
- The Raiders' top backup RBa are Raheem Mostert and Zamir White, who have combined for only 21 rush attempts this season.
- The Titans have allowed 5.15 yards per carry to RBs, the fourth-highest mark in the league.
Panthers WR Tetairoa McMillan vs. Cowboys Projection: 67.5 Receiving Yards
- Panthers WR Tetairoa McMillan has been targeted at least 8 times in all five games this season.
- With his average depth of target checking in at 11.9 yards, he has finished with at least 68 receiving yards in a game three times.
- The 2025 first-round pick has accounted for 25.4% of the Panthers’ targets and 43.4% of their air yards.
- The Cowboys have allowed a league-high 10.37 yards per target to WRs, ahead of just the Jets' 9.99 yards per target.
Cowboys TE Jake Ferguson vs. Jets Projection – 48.5 Receiving Yards
- Cowboys star WR CeeDee Lamb (ankle) has yet to return to practice after sitting out the last two weeks.
- Dallas TE Jake Ferguson finished with at least 7 targets and 7 receptions in both games with Lamb out.
- The Wisconsin product posted 40 receiving yards against the Packers in Week 4, then 49 yards against the Jets in Week 5.
- For the season, the former fourth-round pick has accounted for 24.6% of the Cowboys’ targets.
- The Panthers have allowed 10.55 yards per target to TEs and are the only team in the NFL to allow at least 400 yards to the position.
Browns TE David Njoku vs. Steelers Projection: 32.5 Receiving Yards
- In the first game with Dillon Gabriel starting at QB for the Browns, Njoku hauled in 6 of 9 targets for 67 yards and 1 TD.
- Njoku has posted at least 37 receiving yards in four of his five games.
- The Browns will continue to be thin at receiver with Cedric Tillman (hamstring) on injured reserve.
- The Steelers have allowed the sixth-most yards per target (8.62) to TEs in the league.
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Scoring might not be difficult to come by in Week 6, including in Baltimore when Stafford takes on the Ravens. At the running back position, Jacobs and Jeanty could find themselves in ideal game scripts to be productive. At the tight end spot, Ferguson and Njoku stand out as having plenty of upside.
With a bevy of positions and projection categories to consider, now is the time to build your NFL Lineup on PrizePicks. Just pick More or Less for at least two NFL player stat projections to build your Lineup on PrizePicks. Check out the Playbook for more NFL DFS picks and analysis all the way through the season.
