We could be looking at some blowouts in Week 12, including when RB Jahmyr Gibbs and the Lions host the Giants.
Elsewhere, in one of the highlight matchups of the week, WR Rashee Rice will likely need to play a key role for the Chiefs if they are going to pull out a win over the Colts.
Below, we'll discuss Gibbs, Rice, and get into more of the top Week 12 NFL DFS picks for PrizePicks, including some quick picks to keep in mind.
Quick PrizePicks Picks for NFL Week 12
Here are some quick PrizePicks DFS picks for NFL Week 12, including projections for pass yards, rush yards, and receiving yards.
Vikings QB J.J. McCarthy vs. Packers Projection – 189.5 Pass Yards
- Vikings QB J.J. McCarthy has thrown for 158 yards or fewer in four of his five games.
- The Packers have given up just 21 completions of at least 20 yards this season, the fewest in the NFL.
Seahawks RB Kenneth Walker III vs. Titans Projection – 61.5 Rush Yards
- Seahawks RB Kenneth Walker III has compiled at least 66 rushing yards in six of his 10 games.
- The Titans have allowed the seventh-most rushing yards per game (134.7) in the league.
Patriots WR Stefon Diggs vs. Bengals Projection – 53.5 Receiving Yards
- Patriots WR Stefon Diggs caught 9 of 11 targets for 105 yards against the Jets in Week 11. Over his last two games, he has been targeted 19 times.
- The Bengals have given up the ninth-most yards per target to WRs (8.35).
Top Week 12 NFL DFS Predictions, Picks for PrizePicks
Here are the top NFL DFS picks for Week 12. Player projections via the PrizePicks real-money NFL game.
Lions RB Jahmyr Gibbs vs. Giants Projection – 75.5 Rush Yards
- Gibbs has rushed for at least 136 yards in two of his last five games.
- The star RB is averaging 5.2 yards per carry after racking up 5.6 yards per carry last season.
- The Giants have allowed the most yards per carry to RBs (5.74) in the league.
- According to 4for4 Football, the Giants have given up the second-highest explosive rush rate (14.4%) in the league.
- Gibbs has reeled off 6 carries of at least 40 yards since the start of last season.
Chiefs WR Rashee Rice vs. Colts Projection – 75.5 Receiving Yards
- Rice finished with just 38 receiving yards against the Broncos last week, but he did have 6 receptions and was targeted 9 times.
- Since returning from his suspension, the third-year receiver has been thrown to 35 times across four games.
- Rice has been targeted on 28.7% of his routes.
- The Colts have given up the fifth-most receptions to WRs (135).
Patriots QB Drake Maye vs. Bengals Projection – 252.5 Pass Yards
- Patriots QB Drake Maye completed 73.5% of his pass attempts on his way to throwing for 281 yards and 1 TD vs. the Jets in Week 11.
- The second-year QB has racked up at least 259 passing yards in each of his last four games.
- The Bengals have allowed the second-most yards per pass attempt (7.91) in the league.
- Per 4for4 Football, the Bengals have given up the third-highest explosive pass rate (14.4%) in the NFL.
- The Patriots are slated to welcome back WR Kayshon Boutte, who missed the last two games with a hamstring injury.
Cardinals QB Jacoby Brissett vs. Jaguars Projection – 249.5 Pass Yards
- Cardinals QB Jacoby Brissett threw for 452 yards, 2 TDs, and 2 interceptions in a Week 11 loss to the 49ers.
- The veteran signal-caller has thrown for at least 258 yards in all five of his starts.
- After posting an average target depth of target of 7.0 yards with the Patriots last season, he's up to 7.9 yards this season.
- Brissett has attempted at least 44 passes in three of his five 2025 starts.
- The Jaguars have allowed the seventh-most passing yards per game (236.9).
Cardinals WR Michael Wilson vs. Jaguars Projection – 57.5 Receiving Yards
- Cardinals WR Marvin Harrison Jr. (appendix) has been ruled out for the second straight game.
- With Harrison out in Week 11, WR Michael Wilson caught 15 of 18 targets for 185 yards.
- The rest of the Cardinals’ WRs combined for 10 targets vs. the 49ers.
- Despite his limited role before Harrison went down, Wilson has an average depth of target of 11.0 yards.
Jets WR Adonai Mitchell vs. Ravens Projection – 24.5 Receiving Yards
- With the Jets acquiring WR Adonai Mitchell in a trade deadline day move with the Colts, he was inactive for his new team’s Week 10 matchup against the Browns.
- After having more time to learn the Jets’ offense, Mitchell logged 28 snaps against the Patriots in Week 11. While he finished with just one reception for 10 yards, he was targeted 6 times.
- Jets QB Justin Fields has thrown for 116 or fewer yards in four of his last five games, which has resulted in him being benched in favor of QB Tyrod Taylor for Week 12.
- When Taylor started for Fields in Week 3 against the Buccaneers, he completed 26 of his 36 pass attempts for 197 yards, 2 TDs and 1 interception.
Make NFL Picks on PrizePicks
Maye and Brissett, who were teammates on the Patriots last season, both have favorable matchups headed their way for Week 12. The same can be said for Gibbs, who could run all over a Giants team that has been gashed on the ground.
On the WR side of things, Rice, Wilson and Mitchell could all see significant target shares as they look to rack up yards through the air. With plenty of positions and projection categories to consider, now is the time to make NFL picks on PrizePicks.
Just pick More or Less for at least two NFL player stat projections and cash out if you're right. Check out the Playbook for more NFL DFS picks and analysis all the way through the season.
